Angelini, Gabriele Bani, Alessandro Constantin, Gabriela Rossi, Barbara
Published in
Frontiers in Cellular Neuroscience
The blood–brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) represent two complex structures protecting the central nervous system (CNS) against potentially harmful agents and circulating immune cells. The immunosurveillance of the CNS is governed by immune cells that constantly patrol the BCSFB, whereas during neuroinflammatory...
Zhang, Zhikai Wang, Xuejiang Li, Feng
Published in
Frontiers in Microbiology
Alginate oligosaccharides (AOS) can be obtained by acidolysis and enzymatic hydrolysis. The products obtained by different methods have different structures and physiological functions. AOS have received increasing interest because of their many health-promoting properties. AOS have been reported to exert protective roles for intestinal homeostasis...
Jia, Qingxia Huang, Ziye Wang, Guang Sun, Xia Wu, Yuyun Yang, Bowei Yang, Tongxin Liu, Jianhe Li, Pei Li, Jiongming
...
Published in
Frontiers in Pharmacology
The incidence of kidney stones averages 10%, and the recurrence rate of kidney stones is approximately 10% at 1 year, 35% at 5 years, 50% at 10 years, and 75% at 20 years. However, there is currently a lack of good medicines for the prevention and treatment of kidney stones. Osteopontin (OPN) is an important protein in kidney stone formation, but i...
Jayaraman, Sundararajan Jayaraman, Arathi
Published in
Frontiers in Neurology
Multiple sclerosis is a progressive demyelinating central nervous system disorder with unknown etiology. The condition has heterogeneous presentations, including relapsing-remitting multiple sclerosis and secondary and primary progressive multiple sclerosis. The genetic and epigenetic mechanisms underlying these various forms of multiple sclerosis ...
Zhou, Mi Wu, Jian Tan, Gang
Published in
Irish journal of medical science
Cell division cycle 42 (CDC42) regulates macrophage polarization, vascular inflammation, atherosclerosis progression, and modifies differentiation of T helper (Th) cells, while its potential as a biomarker in coronary heart disease (CHD) patients is still lacking. This study aimed to evaluate CDC42 expression, its correlation with Th1, Th2, and Th1...
Tian, Qi Gao, Huan Ma, Yingying Zhu, Lizhe Zhou, Yan Shen, Yanwei Wang, Bo
Published in
Frontiers in Immunology
Background Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The ECM has been recognized as an important determinant of breast cancer progression and prognosis. Recent studies have revealed a strong link between ECM remodeling and immune cell infiltration in a variety of tumor types. However, the landscape and specif...
Luo, Weihang Hu, Jindong Xu, Weifang Dong, Jingcheng
Published in
Frontiers in Immunology
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th) cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, reflected by distinct phenotypes orchestrated by τh2 or non-Th2 (Th1 and Th17) immune responses at different stages of the disease course. ...
Martner, Anna Grauers Wiktorin, Hanna Törnell, Andreas Ringlander, Johan Arabpour, Mohammad Lindh, Magnus Lagging, Martin Nilsson, Staffan Hellstrand, Kristoffer
Published in
Proceedings of the National Academy of Sciences of the United States of America
This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2-derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered str...
OKINO, C. H. MALAGO JUNIOR, W. MARCONDES, C. R. GIGLIOTI, R. MONTASSIER, H. J. OLIVEIRA, H. N. DE OLIVEIRA, M. C. de S.
Two mutations in the CD4 bovine gene (G>T/Q306H; A>C/K310N) were identified as causative for altered staining with anti-CD4 mAb #CC8. We developed a HRM qPCR for genotyping these mutations and compare with immunophenotyping in different cattle breeds. The assay distinguished five genotypes, B (homozygous, G/A) and C (heterozygous, G/A and T/C), fou...
Pan, Quanren Walls, Andrew F. Pan, Qingjun
Published in
Frontiers in Immunology
