Lemaire, Flora Audonnet, Sandra Perotin, Jeanne-Marie Gaudry, Pierre Dury, Sandra Ancel, Julien Lebargy, François Antonicelli, Frank Deslée, Gaëtan Le Naour, Richard
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Published in
Respiratory Research
BackgroundIn chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP). In the present study, we hypothesized that the pattern of T lymphocytes cytokine expression may be modulated by EP in COPD patients.MethodsCD4+ and CD8+ ...
Fan, Jiaqiao Das, Jugal Kishore Xiong, Xiaofang Chen, Hailong Song, Jianxun
Published in
Frontiers in Oncology
Chimeric antigen receptor (CAR) T (CAR-T) cell transfer has made great success in hematological malignancies, but only shown a limited effect on solid tumors. One of the major hurdles is the poor persistence of infused cells derived from ex vivo activation/expansion and repeated antigen encounter after re-infusion. Bcl-xL has been demonstrated to p...
Mashimo, Keitaro Usui-Ouchi, Ayumi Ito, Yousuke Wakasa-Arai, Rei Yokoi, Norihiko Kawasaki, Satoshi Murakami, Akira Matsuda, Akira Ebihara, Nobuyuki
Published in
Japanese journal of ophthalmology
Vernal keratoconjunctivitis (VKC) is a severe and recurrent allergic conjunctivitis, the mechanism of which is not well understood. In this study, we investigated the role of oncostatin M (OSM) in the pathogenesis of VKC, with a focus on tissue remodeling. Clinical and experimental. The OSM concentrations in tear fluid samples obtained from VKC pat...
Wang, Haiting Teng, Xiangyu Abboud, Georges Li, Wei Ye, Shuang Morel, Laurence
Published in
BMC Immunology
BackgroundSystemic lupus erythematosus is an autoimmune disease characterized by an overproduction of autoantibodies resulting from dysregulation in multiple immune cell types. D-mannose is a C− 2 epimer of glucose that exhibits immunoregulatory effects in models of autoimmune diseases, such as type 1 diabetes, induced rheumatoid arthritis, and air...
van den Bulk, Jitske de Miranda, Noel F.C.C. ten Dijke, Peter
Published in
Clinical Science (London, England : 1979)
Cancers may escape elimination by the host immune system by rewiring the tumour microenvironment towards an immune suppressive state. Transforming growth factor-β (TGF-β) is a secreted multifunctional cytokine that strongly regulates the activity of immune cells while, in parallel, can promote malignant features such as cancer cell invasion and mig...
Koguchi-Yoshioka, Hanako Hoffer, Elena Cheuk, Stanley Matsumura, Yutaka Vo, Sa Kjellman, Petra Grema, Lucian Ishitsuka, Yosuke Nakamura, Yoshiyuki Okiyama, Naoko
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Published in
Communications Biology
Koguchi-Yoshioka et al. demonstrate that functional activities and diversity of T cells are highly maintained in the skin of elderly people when compared with those in the blood regardless of the ethnicity of the participants or the experimental procedures. They also find the accumulation of epidermal T cells with maintained cytokine production in ...
Kim, Dongyoon Wu, Yina Li, Qiaoyun Oh, Yu-Kyoung
Published in
Nano-Micro Letters
HighlightsaCD3/F/AN, anti-CD3e f(ab′)2 fragment-modified and fenofibrate-encapsulated amphiphilic nanoparticle, reprogrammed mitochondrial lipid metabolism of T cells.aCD3/F/AN specifically activated T cells in glucose-deficient conditions mimicking tumor microenvironment, and exerted an effector killing effect against tumor cells.In vivo treatment...
Nouri Barkestani, Mahsa Shamdani, Sara Afshar Bakshloo, Mazdak Arouche, Nassim Bambai, Bijan Uzan, Georges Naserian, Sina
Published in
Cell Communication and Signaling
BackgroundBone marrow derived endothelial progenitor cells (EPCs) are immature endothelial cells (ECs) involved in neo-angiogenesis and endothelial homeostasis and are considered as a circulating reservoir for endothelial repair. Many studies showed that EPCs from patients with cardiovascular pathologies are impaired and insufficient; hence, alloge...
Toor, Salman M. Saleh, Reem Sasidharan Nair, Varun Taha, Rowaida Z. Elkord, Eyad
Published in
Immunology
This review focuses on the multi‐faceted roles of T cells in COVID‐19 pathogenesis and rationalizes their significance in eliciting appropriate antiviral immune responses in COVID‐19 patients and unexposed individuals. In addition, wesummarize the potential therapeutic approaches related to T cells to treat COVID‐19 patients.
Schwarzkopf, Sina Krawczyk, Adalbert Knop, Dietmar Klump, Hannes Heinold, Andreas Heinemann, Falko M. Thümmler, Laura Temme, Christian Breyer, Marianne Witzke, Oliver
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Published in
Emerging Infectious Diseases
We investigated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a group of convalescent, potential blood donors in Germany who had PCR-confirmed SARS-CoV-2 infection. Sixty days after onset of symptoms, 13/78 (17%) study participants had borderline or negative results to an ELISA detecting IgG against the...
