Keren, Aviad Gilhar, Amos Ullmann, Yehuda Zlotkin-Frušić, Marina Soroka, Yoram Domb, Abraham J Levite, Mia
Published in
Immunology
Activated T cells are pathological in various autoimmune and inflammatory diseases including Psoriasis, and also in graft rejection and graft-versus-host-disease. In these pathological conditions, selective silencing of activated T cells through physiological receptors they express remains a clinical challenge. In our previous studies we found that...
Kondou, Keigo Suzuki, Tomoyuki Chang, Myint Oo Takaku, Hiroshi
Published in
Journal of Biological Engineering
BackgroundThe baculovirus (BV) Autographa californica multiple nuclear polyhedrosis virus has been used in numerous protein expression systems because of its ability to infect insect cells and serves as a useful vaccination vector with several benefits, such as its low clinical risks and posttranslational modification ability. We recently reported ...
abdelaal, hadia m. cartwright, emily k. skinner, pamela j.
The development of in situ major histocompatibility complex (MHC) tetramer (IST) staining to detect antigen (Ag)-specific T cells in tissues has radically revolutionized our knowledge of the local cellular immune response to viral and bacterial infections, cancers, and autoimmunity. IST combined with immunohistochemistry (IHC) enables determination...
kumar, gaurav roger, pierre-marie
Bone infection and inflammation leads to the infiltration of immune cells at the site of infection, where they modulate the differentiation and function of osteoclasts and osteoblasts by the secretion of various cytokines and signal mediators. In recent years, there has been a tremendous effort to understand the cells involved in these interactions...
Schepisi, Giuseppe Cursano, Maria Concetta Casadei, Chiara Menna, Cecilia Altavilla, Amelia Lolli, Cristian Cerchione, Claudio Paganelli, Giovanni Santini, Daniele Tonini, Giuseppe
...
Published in
Journal for ImmunoTherapy of Cancer
Prostate cancer (PCa) is one of the main causes of cancer-related death in men. In the present immunotherapy era, several immunotherapeutic agents have been evaluated in PCa with poor results, possibly due to its low mutational burden. The recent development of chimeric antigen receptor (CAR)-T cell therapy redirected against cancer-specific antige...
Thitilertdecha, Premrutai Pluangnooch, Panwadee Timalsena, Sunita Soontrapa, Kitipong
Published in
BMC Complementary and Alternative Medicine
BackgroundLong-term use of most immunosuppressants to treat allergic contact dermatitis (ACD) generates unavoidable severe side effects, warranting discovery or development of new immunosuppressants with good efficacy and low toxicity is urgently needed to treat this condition. Hispidulin, a flavonoid compound that can be delivered topically due to...
di dedda, carla vignali, debora piemonti, lorenzo monti, paolo
An increasing body of evidence indicates that bio-energetic metabolism of T cells can be manipulated to control T cell responses. This potentially finds a field of application in the control of the T cell responses in autoimmune diseases, including in type 1 diabetes (T1D). Of the possible metabolic targets, Glut1 gained considerable interest becau...
Bagadia, Prachi Huang, Xiao Liu, Tian-Tian Murphy, Kenneth M.
Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells m...
Getahun, Andrew Cambier, John C.
B cells play multiple important roles in the pathophysiology of autoimmune disease. Beyond producing pathogenic autoantibodies, B cells can act as antigen-presenting cells and producers of cytokines, including both proinflammatory and anti-inflammatory cytokines. Here we review our current understanding of the non-antibody-secreting roles that B ce...
Ghosh, Tithi Nandi, Partha Ganguly, Nilanjan Guha, Ipsita Bhuniya, Avishek Ghosh, Sarbari Sarkar, Anirban Saha, Akata Dasgupta, Shayani Baral, Rathindranath
...
Published in
Stem Cell Research & Therapy
BackgroundA dynamic interaction between tumor cells and its surrounding stroma promotes the initiation, progression, metastasis, and chemoresistance of solid tumors. Emerging evidences suggest that targeting the stromal events could improve the efficacies of current therapeutics. Within tumor microenvironment (TME), stromal progenitor cells, i.e., ...
