Wang, Jiaqi Lu, Shanshan Yang, Fuming Guo, Yi Chen, Zelin Yu, Nannan Yao, Lin Huang, Jin Fan, Wen Xu, Zhifang
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Published in
Chinese Medicine
Acupuncture is used in the treatment of a variety of inflammatory conditions and diseases. However, the mechanisms of its anti-inflammatory action are complex and have not been systematically investigated. Macrophages are key components of the innate immune system, thus, balancing the M1/M2 macrophage ratio and modulating cytokine levels in the inf...
Dadwal, Nirdosh Mix, Charlie Reinhold, Annegret Witte, Amelie Freund, Christian Schraven, Burkhart Kliche, Stefanie
Published in
Frontiers in Immunology
T cells are the key players of the adaptive immune response. They coordinate the activation of other immune cells and kill malignant and virus-infected cells. For full activation T cells require at least two signals. Signal 1 is induced after recognition of MHC/peptide complexes presented on antigen presenting cells (APCs) by the clonotypic TCR (T-...
Du, Wenting Pasca di Magliano, Marina Zhang, Yaqing
Published in
Frontiers in Oncology
The stroma-rich, immunosuppressive microenvironment is a hallmark of pancreatic ductal adenocarcinoma (PDA). Tumor cells and other cellular components of the tumor microenvironment, such as cancer associated fibroblasts, CD4+ T cells and myeloid cells, are linked by a web of interactions. Their crosstalk not only results in immune evasion of PDA, b...
da Silva Antunes, Ricardo Pallikkuth, Suresh Williams, Erin Dawen Yu, Esther Mateus, Jose Quiambao, Lorenzo Wang, Eric Rawlings, Stephen A Stadlbauer, Daniel Jiang, Kaijun
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Published in
The Journal of infectious diseases
Herein we measured CD4+ T-cell responses against common cold coronaviruses (CCC) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in high-risk health care workers (HCW) and community controls. We observed higher levels of CCC-reactive T cells in SARS-CoV-2-seronegative HCW compared to community donors, consistent with potential high...
Tarke, Alison Sidney, John Methot, Nils Yu, Esther Dawen Zhang, Yun Dan, Jennifer M Goodwin, Benjamin Rubiro, Paul Sutherland, Aaron Wang, Eric
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The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the importance of addressing whether the total CD4+ and CD8+ T cell recognition is also affected. Here, we compare SARS-CoV-2-specific CD4+ and CD8+ T cells against the B.1.1.7, B.1.351, P.1, and CAL.20C lineages in COVID-19 convalescents and in recipients of the Modern...
Chen, Minhui Brackett, Craig M Burdelya, Lyudmila G Punnanitinont, Achamaporn Patnaik, Santosh K Matsuzaki, Junko Odunsi, Adekunle O Gudkov, Andrei V Singh, Anurag K Repasky, Elizabeth A
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Published in
Cancer immunology, immunotherapy : CII
Curaxins are small molecules that bind genomic DNA and interfere with DNA-histone interactions leading to the loss of histones and decondensation of chromatin. We named this phenomenon 'chromatin damage'. Curaxins demonstrated anti-cancer activity in multiple pre-clinical tumor models. Here, we present data which reveals, for the first time, a role...
MacFarlane, Alexander W 4th Yeung, Ho-Man Alpaugh, R Katherine Dulaimi, Essel Engstrom, Paul F Dasari, Arvind Campbell, Kerry S Vijayvergia, Namrata
Published in
Cancer immunology, immunotherapy : CII
High grade neuroendocrine neoplasms (G3 NENs) are rare aggressive tumors with limited treatment options. Twenty-one previously treated patients with metastatic extra-pulmonary G3 NENs were treated with pembrolizumab. Baseline tumor samples were assessed for PD-L1 and tumor infiltrating lymphocytes (TIL). Peripheral blood samples drawn pre-treatment...
Wessels, Inga Fischer, Henrike J Rink, Lothar
Published in
Seminars in cell & developmental biology
The significance of zinc for an efficient immune response is well accepted. During zinc deficiency, an increase in the myeloid to lymphoid immune cells ratio was observed. This results in a disturbed balance of pro- and anti-inflammatory processes as well as defects in tolerance during infections. Consequently, instead of efficiently defending the ...
Bunjun, Rubina Soares, Andreia P. Thawer, Narjis Müller, Tracey L. Kiravu, Agano Ginbot, Zekarias Corleis, Björn Murugan, Brandon D. Kwon, Douglas S. von Groote-Bidlingmaier, Florian
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Published in
Frontiers in Immunology
HIV-1 increases susceptibility to pulmonary infection and disease, suggesting pathogenesis in the lung. However, the lung immune environment during HIV infection remains poorly characterized. This study examined T cell activation and the cytokine milieu in paired bronchoalveolar lavage (BAL) and blood from 36 HIV-uninfected and 32 HIV-infected part...
Shamriz, Oded Kumar, Deepak Shim, Jenny Briones, Michael Quarmyne, Maa-Ohui Chonat, Satheesh Lucas, Laura Edington, Holly White, Michael H. Mahajan, Advay
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Published in
Journal of Clinical Immunology
Purpose T cell-Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis (T cell-EBV-HLH) is prevalent in East Asia and has poor prognosis. Understanding of this disease is limited, and literature regarding prevalence in North America is scarce. Herein, we summarize our experience. Methods A retrospective analysis of T cell-EBV-HLH patients ...
