Network-based identification of miRNAs and transcription factors and in silico drug screening targeting δ-secretase invo...
Published in Heliyon
Alzheimer's disease, miRNA, Systems medicine, δ-secretase, Molecular dynamic simulations.
Network-based identification of miRNAs and transcription factors and in silico drug screening targeting δ-secretase invo...
Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
...
Published in Microbiome
BackgroundThe gut microbiome and iron status are known to play a role in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear.ResultsHere, we applied an integrative systems medicine approach (faecal metagenomics, plasma and urine metabolomics, hepatic transcriptomics) in 2 well-charact...
Prospective multicentric validation of a novel prediction model for paroxysmal atrial fibrillation.
...
Published in Clinical research in cardiology : official journal of the German Cardiac Society
The early recognition of paroxysmal atrial fibrillation (pAF) is a major clinical challenge for preventing thromboembolic events. In this prospective and multicentric study we evaluated prediction scores for the presence of pAF, calculated from non-invasive medical history and echocardiographic parameters, in patients with unknown AF status. The 12...
Constructing and analysing dynamic models with modelbase v1.2.3: a software update
Published in BMC Bioinformatics
BackgroundComputational mathematical models of biological and biomedical systems have been successfully applied to advance our understanding of various regulatory processes, metabolic fluxes, effects of drug therapies, and disease evolution and transmission. Unfortunately, despite community efforts leading to the development of SBML and the BioMode...
Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
...
Background: The gut microbiome and iron status are known to play a role in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear. Results: Here, we applied an integrative systems medicine approach (faecal metagenomics, plasma and urine metabolomics, hepatic transcriptomics) in 2 well-ch...
An Early Stage Researcher's Primer on Systems Medicine Terminology
...Published in Network and Systems Medicine
Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diame...
P7 medicine: Humanizing systems medicine
At the beginning of the 21st century, P4 systems medicine with its predictive, preventive, personalized and participatory elements was introduced to replace the traditional biomedical model. Critics of P4 medicine claim that it exhibits technical holism rather than traditional humanistic holism. To address this criticism, a P7 medical model is prop...
Systems medicine 2030: A Delphi study on implementation in the German healthcare system.
Published in Health policy (Amsterdam, Netherlands)
Systems medicine is based on approaches taken from systems biology, omics research, bio-informatics and network theory. It promises to facilitate a better understanding of the causes of diseases, detection at an earlier stage, and the use of tailor-made approaches to prevention and therapy. This study provides information on how systems medicine co...
Data-driven translational prostate cancer research: from biomarker discovery to clinical decision
Published in Journal of Translational Medicine
Prostate cancer (PCa) is a common malignant tumor with increasing incidence and high heterogeneity among males worldwide. In the era of big data and artificial intelligence, the paradigm of biomarker discovery is shifting from traditional experimental and small data-based identification toward big data-driven and systems-level screening. Complex in...
The INFECT-Project: An International and Multidisciplinary Project on Necrotizing Soft Tissue Infections.
Published in Advances in experimental medicine and biology
This book describes clinical and microbiologic aspects, pathogenesis, and diagnostics, related to the severe and rapidly spreading necrotizing soft tissue infections. The work has its foundation in a recently completed European Union funded FP7-project called INFECT, which during the period 2013-2018 focused on utilizing a systems medicine approach...
