Murata, Takaki Nomura, Shuko Yamamori, Eiko Takahashi, Shoki Takase, Kei
Published in
Radiology case reports
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple organ systems. Cerebral aneurysm formation is a rare central nervous system manifestation of SLE and tends to present as subarachnoid hemorrhage. Here, we report a 34-year-old woman with SLE complicated by a thrombosed aneurysm that had arose at the origin of a per...
Mirouse, Adrien Parrot, Antoine Audigier, Vincent Demoule, Alexandre Mayaux, Julien Géri, Guillaume Mariotte, Eric Bréchot, Nicolas de Prost, Nicolas Vautier, Mathieu
...
Published in
Critical Care
BackgroundDiffuse alveolar hemorrhage (DAH) occurs during the course of autoimmune disease and may be life threatening. The objective was to assess characteristics and prognosis factors of DAH who required intensive care unit (ICU) admission in patients with autoimmune diseases.MethodsFrench multicenter retrospective study including patients presen...
Ammar, Waleed Taha, Moataz Baligh, Essam Osama, Dina
Published in
The Egyptian Heart Journal
BackgroundCardiovascular disease is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE) patients. Accurate risk stratification would require a simple, non-invasive index integrating all traditional and emerging risk factors. Vascular stiffness fulfills these requirements and has better predictive value for cardiovascular ...
Hong, Soon-Min Liu, Can Yin, Zhihua Wu, Lingling Qu, Bo Shen, Nan
Published in
Current Rheumatology Reports
Purpose of ReviewMicroRNAs (miRNAs) play essential roles in immune abnormalities and organ damage of systemic lupus erythematosus (SLE). Current findings have indicated potential clinical applications of miRNAs for combating SLE. Here, we review recent evidence which support the notions that miRNAs can be novel biomarkers and therapeutic agents for...
Desnoyers, Marie Dufrost, Virginie Wahl, Denis Zuily, Stéphane
Published in
Current Rheumatology Reports
Purpose of ReviewAntiphospholipid syndrome (APS) is a chronic autoimmune disease that can be seen as a burden, with consequences on patients’ daily life. Health has traditionally been measured using measures of morbidity or mortality. Health-related quality of life (HRQoL) is a concept that includes quality of life through physical, mental, and soc...
Aringer, Martin Leuchten, Nicolai Johnson, Sindhu R.
Published in
Current Rheumatology Reports
Purpose of the ReviewClassification criteria define the patient population for clinical trials and translational studies, but also influence current understanding of the disease. This review attempts to delineate the development from the American College of Rheumatology (ACR) 1982 to the European League Against Rheumatism (EULAR)/ACR 2019 classific...
Pravda, Jay
Published in
Molecular Medicine
Although the immune response has a prominent role in the pathophysiology of ulcerative colitis, sepsis, and systemic lupus erythematosus, a primary immune causation has not been established to explain the pathogenesis of these diseases. However, studies have reported significantly elevated levels of colonic epithelial hydrogen peroxide (a known col...
Wilkinson, Christel Henderson, Robert B. Jones-Leone, Angela R. Flint, Shaun M. Lennon, Mark Levy, Roger A. Ji, Beulah Bass, Damon L. Roth, David
Published in
Arthritis Research & Therapy
BackgroundElevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway activation. This post hoc meta-analysis of BLISS-52 and BLISS-76 explored the relationship between baseline BLyS mRNA/protein levels a...
Tesser, Alessandra de Carvalho, Luciana Martins Sandrin-Garcia, Paula Pin, Alessia Pastore, Serena Taddio, Andrea Roberti, Luciana Rodrigues de Paula Queiroz, Rosane Gomes Ferriani, Virginia Paes Leme Crovella, Sergio
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Published in
Arthritis Research & Therapy
BackgroundSystemic lupus erythematosus (SLE) is a complex multi-system disease, characterized by both autoimmune and autoinflammatory clinical and laboratory features. The role of type I interferon (IFN) in SLE has been demonstrated from the 2000s, by gene expression analyses showing significant over-expression of genes related to type I IFN signal...
Kim, Taehyeung Bae, Sang-Cheol Kang, Changwon
Published in
Arthritis Research & Therapy
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune inflammatory rheumatic disease. SLE susceptibility is affected by multiple genetic elements, environmental factors, and their interactions. We aimed in this study to statistically and functionally characterize a gene-gene interaction (epistasis) recently documented to affect SLE risk.Met...
