Mai, Lloyd Asaduzzaman, Arundip Noamani, Babak Fortin, Paul R. Gladman, Dafna D. Touma, Zahi Urowitz, Murray B. Wither, Joan
Published in
Arthritis Research & Therapy
ObjectivesType I interferons (IFNs) play an important role in the pathophysiology of systemic lupus erythematosus (SLE). While cross-sectional data suggest an association between IFN-induced gene expression and SLE disease activity, interest in this as a biomarker of flare has been tempered by a lack of fluctuation with disease activity in the majo...
Zhang, Chunyi Gao, Congcong Di, Xueqi Cui, Siwan Liang, Wenfang Sun, Wenbo Yao, Menghui Liu, Shengyun Zheng, Zhaohui
Published in
Arthritis Research & Therapy
BackgroundLupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, which is involved in mechanism of many diseases. However, the role of circRNA in lupus nephritis has been rarely reported. In this stud...
Dupuis, Maria Luisa Pagano, Maria Teresa Pierdominici, Marina Ortona, Elena
Published in
Biology of Sex Differences
Over the last decades, a central role for vitamin D in immune modulation has been well established. The active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, through the interaction with vitamin D receptor, exerts different activities on the innate and adaptive immune system, among which suppression of inflammation and promotion of tolerogenic r...
Xiang, Yirong Li, Mengtao Luo, Hui Wang, Yanhong Duan, Xinwang Zhao, Cheng Zhan, Feng Wu, Zhenbiao Li, Hongbin Yang, Min
...
Published in
Arthritis Research & Therapy
BackgroundScarring alopecia in systemic lupus erythematosus (SLE) patients caused reduced life quality and prolonged disease course. This case-control study aims to survey the prevalence of scarring alopecia during the disease course of SLE and evaluate the risk factors for scarring alopecia in Chinese SLE patients.MethodsSLE patients in Chinese SL...
El-Desoky, Manal M. Shemies, Rasha S. El-Bahnasawy, Amany S. Mostafa, Nora Elhelaly, Mona
Published in
Egyptian Journal of Medical Human Genetics
BackgroundBiomarkers that enhance overall diagnosis and prognosis of systemic lupus erythematosus (SLE) have a growing need to be recognized. The use of long non-coding ribonucleic acids (lncRNAs) as biomarkers in this regard is still largely unexplored. This study aimed to evaluate lncRNA [metastasis-associated lung adenocarcinoma transcript 1 (MA...
Wang, Haiting Teng, Xiangyu Abboud, Georges Li, Wei Ye, Shuang Morel, Laurence
Published in
BMC Immunology
BackgroundSystemic lupus erythematosus is an autoimmune disease characterized by an overproduction of autoantibodies resulting from dysregulation in multiple immune cell types. D-mannose is a C− 2 epimer of glucose that exhibits immunoregulatory effects in models of autoimmune diseases, such as type 1 diabetes, induced rheumatoid arthritis, and air...
Zhang, Junhui Liu, Yuan Shi, Guixiu
Published in
Clinical rheumatology
Systemic lupus erythematosus (SLE) was an autoimmune disease with a large variety of clinical manifestations and involving many organs. Its exact etiology was unclear, and studies had shown that T cells may play an important role. In this study, we wished to study the regulatory mechanism of circRNA in the T cells from SLE patients. GSE84655 was re...
González-Naranjo, Luis Alonso Coral-Enríquez, Jaime Alberto Restrepo-Escobar, Mauricio Muñoz-Vahos, Carlos Horacio Jaramillo-Arroyave, Daniel Vanegas-García, Adriana Lucía Eraso, Ruth Vásquez, Gloria Jaimes, Fabián
Published in
Clinical rheumatology
To identify factors associated with active tuberculosis (TB) in patients with systemic lupus erythematosus (SLE). We performed a retrospective case-control study in two tertiary care teaching hospitals in Medellín, Colombia. From January 2007 to December 2017, a total of 268 patients with SLE were included. SLE patients with TB (cases) were matched...
Lou, Qiu Yue Li, Zhen Teng, Ying Xie, Qiao Mei Zhang, Man Huang, Shun Wei Li, Wen Fei Chen, Yang Fan Pan, Fa Ming Xu, Sheng Qian
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Objectives : To explore the associations of FKBP4 and FKBP5 gene polymorphisms with disease susceptibility, glucocorticoid (GC) efficacy, anxiety, depression, and health-related quality of life (HRQOL) in systemic lupus erythematosus (SLE) patients. Methods : All subjects were collected from the First and the Second Affiliated Hospital of Anhui Med...
Wu, Qian Xu, Zhiwei Dan, Yi Lin Wang, Peng Mao, Yan Mei Zhao, Chan Na Zou, Yan Feng Ye, Dong Qing Hu, Wenbiao Pan, Hai Feng
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Currently, the correlation between ambient temperature and systemic lupus erythematosus (SLE) hospital admissions remains not determined. The aim of this study was to explore the correlation between ambient temperature and SLE hospital admissions in Hefei City, China. An ecological study design was adopted. Daily data on SLE hospital admissions in ...
