RORgamma agonists enhance survival and memory of type 17 T cells and improve anti-tumor activity
...Published in Journal for ImmunoTherapy of Cancer
The `dnet’ approach promotes emerging research on cancer patient survival
Published in Genome Medicine
We present the `dnet’ package and apply it to the `TCGA’ mutation and clinical data of >3,000 patients. We uncover the existence of an underlying gene network that at least partially controls cancer `survivalness’, with mutations that are significantly correlated with patient survival, yet independent of tumour origin and type. The survivalness net...
Indirect genomic effects on survival from gene expression data
Published in Genome Biology
In cancer, genes may have indirect effects on patient survival, mediated through interactions with other genes. Methods to study the indirect effects that contribute significantly to survival are not available. We propose a novel methodology to detect and quantify indirect effects from gene expression data. We discover indirect effects through seve...
