Han, Soo-Hong Kim, Hyung Kyung Jang, Yoon Lee, Hyeon Hae Rhie, Jeongbae Han, Donghun Oh, Jongbeom Lee, Soonchul
Published in
BMC Musculoskeletal Disorders
Background In this study, we investigated whether substance P (SP) or calcitonin gene-related peptide (CGRP) expression is associated with tendon degeneration in patients with lateral epicondylitis. Methods Twenty-nine patients who underwent surgical treatment for lateral epicondylitis were enrolled in the final analyses. Extensor carpi radialis br...
Babina, Magda Wang, Zhao Franke, Kristin Zuberbier, Torsten
Published in
Cells
Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD). Mast cells (MCs) are overabundant in AD lesions and show signs of degranulation, but it remains unknown wheth...
Smiley, Rebecca McCallum, Richard Showkat Ali, Mohammed
Published in
Gastroenterology Research
Background Substance P (SP) and neuropeptide Y (NPY), excitatory and inhibitory neuropeptides, respectively, may impact gastric motility in patients with diabetic mellitus (DM). We investigated these neuropeptide levels, NPY receptors, total nitric oxide synthase (NOS) levels, and neuronal NOS alpha (nNOSα) activation status and levels in streptozo...
Mehboob, Riffat Lavezzi, Anna Maria
Published in
Journal of the Neurological Sciences
• COVID-19 is the biggest public health crisis of recent times. • Children are not significantly affected in the same way as adults by COVID-19. • The infant's immune system might protect from the ‘cytokine storm’ of adults. • Increased expression of substance P in brains is here proposed as a possible cause. • Aprepitant could be a promising thera...
Hsieh, Yueh-Ling Wu, Bor-Tsang Yang, Chen-Chia
Published in
Experimental brain research
This study explores the involvement of substance P (SP) in the parabrachial nucleus (PBN) and central amygdaloid nucleus (CeA) in the nociception-emotion link and of rats with masticatory myofascial pain (MMP) induced by chronic tetanic eccentric muscle contraction. A total of 18 rats were randomly and equally assigned for MMP (MMP group) and sham-...
Feickert, Martin Burckhardt, Bjoern B
Published in
Peptides
The neurokinin-1 receptor plays a profound role in inflammatory processes and is involved in immune cell differentiation, cytokine release, and mast cell activation. Due to their similar peptide structures, the neurokinin-1 receptor does not discriminate between the endogenous ligands substance P (SP) and human hemokinin-1 (hHK-1), which both demon...
Malik, Aastha Saha, Sarama Morya, Rajesh Kumar Bhadada, Sanjay Kumar Singh, Praveen Kumar Rana, Satya Vati
Published in
Biochemical genetics
Uncontrolled diabetes mellitus may affect any part of the gastrointestinal tract (GIT) and impact negatively the quality of life. Angiotensin-converting enzyme (ACE) gene polymorphism can have direct effect on circulating level of ACE which further modifies the degradation of substance P and thus may influence the gut motility. Hence, it could be h...
Wang, Gang He, Chen-Jun Liang, Xiao-Song Zhou, Yi-Fu Chen, Si-Hua
Published in
Clinica chimica acta; international journal of clinical chemistry
Substance P (SP) is implicated in brain inflammation. We clarified relationship between serum SP concentrations and functional outcome of acute intracerebral hemorrhage (ICH). We quantified admission serum SP concentrations in 106 ICH patients. The primary outcome measure was a poor outcome at 90 days (modified Rankin Scale score ≥ 3) after onset. ...
ZHANG, Rong yi ZHU, Ben fan WANG, Li kui SONG, Yang ZHAO, Jia gui GUO, Yan ZHAO, Long CHEN, Shi
ABSTRACT Background: Acupuncture has been widely used for alleviating pain. However, its mechanisms remain largely enigmatic. Objective: In the present study, we focused on whether the analgesic effect of electroacupuncture is related to its regulation on adenosine and substance P expression. Methods: We established chronic inflammatory pain model ...
Jia, Weigang Wang, Wei Li, Rui Zhou, Quanyu Qu, Ying Jia, Yumei Zhang, Zhiheng Wan, Chengwei Zhang, Wanwan
Published in
BMC Complementary Medicine and Therapies
BackgroundIn recent years, it has been reported that Qinbai Qingfei Concentrated Pellet (QQCP) has the effect of relieving cough and reducing sputum. However, the therapeutic potentials of QQCP on post-infectious cough (PIC) rat models has not been elucidated. So the current study was aimed to scientifically validate the efficacy of QQCP in post in...
