Jeong, Yun-Mi Cheng, Xian Wu Lee, Kyung Hye Lee, Sora Cho, Haneul Kim, Weon
Published in
BMC Molecular and Cell Biology
BackgroundLocalization of neurokinin 1 receptor (NK1R), the endogenous receptor for neuropeptide substance P (SP), has already been described for the right atrium (RA) of the heart. However, the biological role of SP/NK1R signal pathways in the RA remains unclear.Sprague-Dawley rats were randomly divided into 4 groups (n = 22 each); subjected to sh...
Szereda-Przestaszewska, Małgorzata Kaczyńska, Katarzyna
Published in
Autonomic neuroscience : basic & clinical
Numerous neurotransmitters identified in the central nervous system play role in ventilatory control. This mini-review focuses on the respiratory effects of two neurotransmitters: serotonin (5-HT) and substance P (SP). We discuss their co-localization in medullary raphe nuclei, expression of proper receptors within the specific regions of respirato...
Schreiber, Ulrich Engl, Christian Bayer, Malte König, Simone
Published in
Journal of pharmaceutical and biomedical analysis
Recently, we developed a bradykinin reporter assay and demonstrated the differing protease activity in Complex Regional Pain Syndrome patients vs. controls. In order to further characterize CRPS pathophysiology, the neuropeptide substance P was evaluated as possible reporter substance, here. It was labeled with a chromophore at the lysine residue a...
Yan, Kaixian Lin, Qin Tang, Kailiang Liu, Shuang Du, Yi Yu, Xijiao Li, Shu
Published in
BMC Oral Health
BackgroundBoth substance P and hypoxia-inducible factor 1 alpha (HIF-1α) are involved in inflammation and angiogenesis. However, the relationship between substance P and HIF-1α in rat periodontitis is still unknown.MethodsLigation-induced rat periodontitis was established to observe the distribution and expression of substance P and HIF-1α by immun...
Lee, Ming Tatt Chiu, Yu-Ting Chiu, Yu-Chun Hor, Chia Chun Lee, Hsin-Jung Guerrini, Remo Calo, Girolamo Chiou, Lih-Chu
Published in
Journal of Biomedical Science
BackgroundStress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal links remain unclear. Here, we reveal an unprecedented sequential cascade involving these mediators in the la...
Wang, Qian Wang, Yongxin Pang, Silin Zhou, Jia Cai, Jie Shang, Jing
Published in
BMC Complementary and Alternative Medicine
BackgroundVernonia anthelmintica (L.) willd is a traditional urgur herb in China for a long history. Its alcohol extract (AVE) has been proved to promote hair follicle growth in C57BL/6 mice. We conducted this study to investigate the hair-growth effects of AVE in stressed mice and its possible mechanism of action.MethodsThe hair-follicle growth ef...
Tian, Li Qian, Weibin Qian, Qiuhai Zhang, Wei Cai, Xinrui
Published in
Journal of Natural Medicines
AbstractGingerol, a biologically active component in ginger, has shown antiemetic properties. Our study aimed to explore the underlying mechanisms of gingerol on protecting rats and minks from chemotherapy-induced nausea and vomiting. The preventive impact of gingerol was evaluated in the pica model of rats and the vomiting model of minks induced b...
Schreiber, Ulrich Bayer, Malte König, Simone
Published in
Data in Brief
In the associated main paper (“Labeled substance P as a neuropeptide reporter substance for enzyme activity” ( http://doi.org/10.1016/j.jpba.2019.112953 )), substance P was shown to be a valuable neuropeptide reporter substance to monitor the protease activity of serum. The assay was developed based on the predecessor assay using bradykinin (“A vot...
Muñoz, Miguel Rosso, Marisa Coveñas, Rafael
Published in
Mini reviews in medicinal chemistry
Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer death among females. BC cells not showing HER-2/Neu amplification and not expressing estrogen/progesterone receptors are named triple-negative BC (TNBC) cells. TNBC represents 10-15% of all BC and is associated with an aggressive clinical course. TNBC patient...
Gao, Xiao-Wei Zhang, Xiao-Min Liu, Hai-Yan Wang, Shan-Shan Dong, Hua-Jiang
Published in
International ophthalmology
The mechanisms of naso-ocular interaction in allergic rhinoconjunctivitis are not well understood. Neurogenic inflammation affects both eyes and nose via the same neurogenic factors. The purpose of this study was to investigate the effects of neurogenic inflammation on conjunctival inflammation following nasal allergen provocation. Sensitized rats ...
