Published in IBRO neuroscience reports
Ischemic stroke frequently causes motor impairments. Despite exercise can improve motor outcomes, many stroke survivors remain life-long disabled. Understanding the mechanisms associated with motor recovery after a stroke is necessary to develop treatments. Here, we show that endogenous DA transmission is required for optimal motor skill recovery f...
Optimal criteria for diagnosing and monitoring response to treatment for infectious and inflammatory medium-large vessel intracranial vasculitis presenting with stroke are lacking. We integrated intracranial vessel wall MRI with arterial spin labelling into our routine clinical stroke pathway to detect presumed inflammatory intracranial arterial va...
Published in European journal of preventive cardiology
There is concern that cardiovascular disease (CVD) in young adults is rising. However, current trends in the UK are unknown. We investigated sex-specific trends in the incidence and prevalence of CVD in young UK adults. A series of annual (1998-2017) cohort and cross-sectional studies were conducted to estimate incidence rates and prevalence in men...
Published in Neuroradiology
Development of a freely available stroke population-specific anatomical CT/MRI atlas with a reliable normalisation pipeline for clinical CT. By reviewing CT scans in suspected stroke patients and filtering the AIBL MRI database, respectively, we collected 50 normal-for-age CT and MRI scans to build a standard-resolution CT template and a high-resol...
Published in Acta radiologica (Stockholm, Sweden : 1987)
Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is a grading system to assess the extent and distribution of early ischemic changes. To assess inter-rater agreement for total and regional ASPECTS on non-contrast computed tomography (NCCT) images, CT angiography source images (CTA-SI), and CT-perfusion cerebral blood volume (CTP-CBV...
Published in Cardiovascular drugs and therapy
Although direct oral anticoagulants are effective and safe in preventing stroke in atrial fibrillation (AF) patients with low body weight, data remain limited in AF patients with extremely low body weight (60 kg (n = 1019, 33.7%), 50-60 kg (n = 1126, 37.2%), and
Published in Archives of physical medicine and rehabilitation
The present study aimed to create a shorter version of the Action Research Arm Test (ARAT) without compromising its measurement properties. Secondary analysis of stroke recovery cohorts that used the ARAT to measure upper limb impairment. Rehabilitation centers. Patients with stroke from 5 different stroke recovery cohorts (N=1425). Not applicable....
Published in European journal of trauma and emergency surgery : official publication of the European Trauma Society
Blunt cerebrovascular injuries (BCVI) are a rare but serious complication after trauma. Among patients with BCVI, neurological status is altered in 30% of cases and the prognosis seems to be associated with ischemic complications. The aim of this study was to assess the long-term outcome of BCVI-associated ischemic events. This retrospective cohort...
Published in Fundamental & clinical pharmacology
The aim of the study is to describe the use of antihypertensive and lipid-lowering drugs in post-stroke secondary prevention in France. This is a prospective cohort study based on a representative sample of the French health insurance system database. All patients aged 45 and over, hospitalized for a first stroke between 1 January 2009 and 31 Decem...
BackgroundSpontaneous intracerebral hemorrhage is a potentially devastating cause of brain injury, often occurring secondary to hypertension. Contrast extravasation on computed tomography angiography (CTA), known as the spot sign, has been shown to predict hematoma expansion and worse outcomes. Although hypertension has been associated with an incr...
