Published in Medical hypotheses
Group B streptococcus (Streptococcus agalactiae) is proposed as causative agent for the development of the sporadic form of Alzheimer's disease. Using a fibrinogen binding protein, aggregates are formed including A-beta. After triggering Alzheimer's disease by the bacterium, the next down-stream events mainly follow the well known so called A-beta ...
Published in Microbial drug resistance (Larchmont, N.Y.)
The aim of this work was to determine the susceptibility, molecular profile, and clonal relationship in Streptococcus agalactiae (group B Streptococcus [GBS]) isolated from vaginal-rectal swab samples. We worked with 200 isolates collected from pregnant women between 35 and 37 weeks of gestation. The macrolide-lincosamide-streptogramin B (MLSB) res...
Published in Veterinary Research
Streptococcus agalactiae is one of the causative agents of subclinical mastitis, a common disease of dairy cows that causes great economic losses in the industry worldwide. It is thought that pathology is mainly due to inflammatory damage of bovine mammary epithelial cells (bMECs); however, the mechanism by which S. agalactiae damages the bMECs is ...
Published in Virulence
Bacterial meningitis remains a substantial cause of mortality worldwide and survivors may have severe lifelong disability. Although we know that meningeal bacterial pathogens must cross blood-central nervous system (CNS) barriers, the mechanisms which facilitate the virulence of these pathogens are poorly understood. Here, we show that adenosine fr...
Resumo: Um dos grandes desafios na piscicultura é a ocorrência de doenças. Diferentes antibióticos comerciais são utilizados para controlar essas doenças, porém, seu uso prolongado pode levar à resistência de tais medicamentos. Deste modo, faz-se necessário o uso de métodos alternativos e inovadorespara o controle sanitário em peixes. Os óleos esse...
Resumo: O consumo e cultivo de peixes contaminados com Aeromonas hydrophila e Streptococcus agalactiae podem ocasionar doenças infecciosas tanto em seres humanos como em animais. Para sanar este problema utilizam-se antibióticos, porém seu uso indiscriminado pode causar resistência microbiana, deixar resíduos no alimento e contaminar o meio ambient...
Published in Journal of bacteriology
Streptococcus agalactiae (group B streptococcus [GBS]) is a major cause of infections in newborns, pregnant women, and immunocompromised patients. GBS strain CNCTC10/84 is a clinical isolate that has high virulence in animal models of infection and has been used extensively to study GBS pathogenesis. Two unusual features of this strain are hyperhem...
Published in Molecular immunology
Galectins are the family of carbohydrate-binding proteins that participate in host-pathogen interaction. In this study, a galectin-4 homolog (OnGal-4) from Nile tilapia (Oreochromis niloticus) was characterized. The open reading frame of OnGal-4 was 1194 bp, encoding a peptide of 397 amino including two CRD regions and two carbohydrate recognition ...
Published in Journal of photochemistry and photobiology. B, Biology
It is well documented that blue light absorption by bacterial chromophores triggers downstream production of reactive oxygen species (ROS), which in turn results in bacterial cell death. To elucidate the importance of chromophores in the bactericidal effect of blue light, and to determine whether blue light absorption per se or the presence of porp...
Published in Emerging infectious diseases
We analyzed group B Streptococcus (GBS) neonatal invasive infections reported during 2007-2019 in France. The hypervirulent clonal complex (CC) 17 GBS was responsible for 66% (827/1,262) of cases. The role of CC17 GBS increased over time (p for trend = 0.0001), together with the emergence of a multidrug-resistant CC17 GBS sublineage.
