Cox, Kristin E Turner, Michael A Lwin, Thinzar M Amirfakhri, Siamak Kelly, Kaitlyn J Hosseini, Mojgan Ghosh, Pradipta Obonyo, Marygorret Hoffman, Robert M Yazaki, Paul J
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BackgroundGastric cancer poses a major diagnostic and therapeutic challenge as surgical resection provides the only opportunity for a cure. Specific labeling of gastric cancer could distinguish resectable and nonresectable disease and facilitate an R0 resection, which could improve survival.MethodsTwo patient-derived gastric cancer lines, KG8 and K...
Dayyani, Farshid Chao, Joseph Lee, Fa-Chyi Taylor, Thomas Neumann, Kristen Cho, May
BACKGROUND: Most patients with metastatic gastroesophageal adenocarcinoma (mGEA) progress on immune checkpoint inhibitors (ICIs). Novel approaches to overcome resistance to ICI in mGEA are needed. Cabozantinib is a multi-tyrosine kinase inhibitor thought to enhance the immunomodulatory effects of ICI. This study evaluated the combination of cabozan...
Shariff, Bushra Barnett, Reagan Dayyani, Farshid Maron, Steven Mcgriskin, Rory Klempner, Samuel Donderici, Elifnur Zhang, Nicole Masannat, Jude Drusbosky, Leylah
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PURPOSE: In addition to the existing biomarkers HER2 and PD-L1, FGFR2b has become an area of interest for the development of new targeted-based treatment. Given that clinical evaluation of FGFR2 targeted therapy is underway, we sought to elucidate the genomic landscape of FGFR2amp in gastroesophageal cancer (GEC) using a circulating tumor DNA (ctDN...
Collatuzzo, Giulia Cortez Lainez, Jacqueline Pelucchi, Claudio Negri, Eva Bonzi, Rossella Palli, Domenico Ferraroni, Monica Zhang, Zuofeng Yu, Guo-Pei Lunet, Nuno
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PURPOSE: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC. METHODS: We pooled data from 11 population or hospital-based case-control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histo...
Kim, Min-Jeong Kim, Han-Na Jacobs, Jonathan Yang, Hyo-Joon
BACKGROUND/AIMS: While DNA methylation and gastric microbiome are each associated with gastric cancer (GC), their combined role in predicting GC remains unclear. This study investigated the potential of a combined DNA methylation and gastric microbiome signature to predict Helicobacter pylori-negative GC. METHODS: In this case-control study, we con...
Li, Amy Sedighim, Shaina Tajik, Fatemeh Khan, Aaqil Radhakrishnan, Vinodh Dayyani, Farshid Senthil, Maheswari
PURPOSE: Despite advances in systemic therapy, outcomes of patients with gastric cancer (GC) peritoneal carcinomatosis (PC) remain poor, in part because of poor penetrance of systemic therapy into peritoneal metastasis due to the plasma-peritoneal barrier and anarchic intra-tumoral circulation. Hence, regional treatment approach with administration...
Wainberg, Zev Kang, Yoon-Koo Lee, Keun-Wook Qin, Shukui Yamaguchi, Kensei Kim, In-Ho Saeed, Anwaar Oh, Sang Li, Jin Turk, Haci
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BACKGROUND: We report the final results of the randomized phase 2 FIGHT trial that evaluated bemarituzumab, a humanized monoclonal antibody selective for fibroblast growth factor receptor 2b (FGFR2b), plus mFOLFOX6 in patients with FGFR2b-positive (2 + /3 + membranous staining by immunohistochemistry), HER-2-negative gastric or gastroesophageal jun...
Sassano, Michele Seyyedsalehi, Monireh Collatuzzo, Giulia Pelucchi, Claudio Bonzi, Rossella Ferraroni, Monica Palli, Domenico Yu, Guo-Pei Zhang, Zuofeng López-Carrillo, Lizbeth
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BACKGROUND: Previous studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC. METHODS: Fourteen case-control st...
Cecchini, Michael Cleary, James M Shyr, Yu Chao, Joseph Uboha, Nataliya Cho, May Shields, Anthony Pant, Shubham Goff, Laura Spencer, Kristen
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BackgroundOur preclinical work revealed tumour hypoxia induces homologous recombination deficiency (HRD), increasing sensitivity to Poly (ADP-ribose) polymerase inhibitors. We aimed to induce tumour hypoxia with ramucirumab thereby sensitising tumours to olaparib.Patients and methodsThis multi-institution single-arm Phase 1/2 trial enrolled patient...
Botta, Gregory P Chao, Joseph Ma, Hong Hahn, Michael Sierra, Gloria Jia, Jie Hendrix, Amanda Y Fong, Joy V Nolte Ween, Audrey Vu, Peter
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Treatment of hematologic malignancies with patient-derived anti-CD19 chimeric antigen receptor (CAR) T-cells has demonstrated long-term remissions for patients with otherwise treatment-refractory advanced leukemia and lymphoma. Conversely, CAR T-cell treatment of solid tumors, including advanced gastric cancer (GC), has proven more challenging due ...