Da Silva Sanchez, Alejandro J Zhao, Kun Huayamares, Sebastian G Hatit, Marine Z C Lokugamage, Melissa P Loughrey, David Dobrowolski, Curtis Wang, Shuaishuai Kim, Hyejin Paunovska, Kalina
...
Published in
Journal of controlled release : official journal of the Controlled Release Society
Lipid nanoparticles (LNPs) have delivered siRNA and mRNA drugs in humans, underscoring the potential impact of improving the therapeutic window of next-generation LNPs. To increase the LNP therapeutic window, we applied lessons from small-molecule chemistry to ionizable lipid design. Specifically, given that stereochemistry often influences small-m...
Hahn, Dongyup Wang, Weihong Choi, Hyukjae Kang, Heonjoong
Published in
Scientific Reports
We report a method for the simultaneous determination of the sequence and absolute configuration of peptide amino acids using a combination of Edman degradation and HPLC–MS/CD. Phenylthiohydantoin (PTH) derivatives of 20 pairs of standard d - and l -amino acids were synthesized by the Edman reaction. The CD spectra of the derivatives revealed that ...
Elder, Felicity C T Pascoe, Ben Wells, Stephen Sheppard, Samuel K Snape, Jason Gaze, William H Feil, Edward J Kasprzyk-Hordern, Barbara
Published in
Water research
Wastewater treatment plants have been highlighted as a potential hotspot for the development and spread of antibiotic resistance. Although antibiotic resistant bacteria in wastewater present a public health threat, it is also possible that these bacteria play an important role in the bioremediation through the metabolism of antibiotics before they ...
Wang, Xi-Chao Li, Bo Ju, Cheng-Wei Zhao, Dongbing
Published in
Nature Communications
Transition metal-catalyzed reactions of silacyclobutanes to access structurally diverse organosilicon compounds have attracted attention in recent years. Here, the authors show nickel-catalysed, ligand-controlled chemodivergent reactions of these compounds with alkynes to (benzo)silacyclohexenes and allyl vinylsilane.
Jin, Ming Yu Zhen, Qianqian Xiao, Dengmengfei Tao, Guanyu Xing, Xiangyou Yu, Peiyuan Xu, Chen
Published in
Nature Communications
Non-covalent π interactions have been rarely used as a design element for promoting chemical reactions. Here the authors report a Sharpless asymmetric dihydroxylation (SAD)-based kinetic resolution in which a-priori-designed non-covalent forces play a central role in differentiating the enantiomeric substrates.
Tang, Shengbiao Zhang, Peng Shao, Ying Sun, Jiangtao
Published in
Nature Communications
Developing classes of substrates for the Nazarov reaction is an important endeavour for synthetic chemistry. Here, the authors report how enyne diketones undergo rhodium-catalyzed metal-organo relay catalysis for the enantioselective construction of chiral allene cyclopentenones via Nazarov cyclisation in good yields and enantioselectivities.
Bray, Daniel P Hall, David R Harte, Steven J Farman, Dudley I Vankosky, Meghan A Mori, Boyd A
Published in
Journal of chemical ecology
The canola flower midge, Contarinia brassicola Sinclair (Diptera: Cecidomyiidae), is a newly-described species that induces galls on canola, Brassica napus Linnaeus and Brassica rapa Linnaeus (Brassicaceae). Identification of the sex pheromone of C. brassicola is essential to developing monitoring tools to elucidate the geographic range and hosts o...
Zhang, Guan Zhang, Zhihan Hou, Mengyuan Cai, Xinping Yang, Kai Yu, Peiyuan Song, Qiuling
Published in
Nature communications
Compared with the well-developed carbon-stereogenic chemistry, the construction of boron-stereogenic compounds remains undeveloped and challenging. Herein, the previously elusive catalytic enantioselective construction of boron-stereogenic compounds has been achieved through enantioselective desymmetric B-H bond insertion reaction. The B-H bond ins...
Balahoju, Shivaprasad Achary Maurya, Yogesh Kumar Chmielewski, Piotr J Lis, Tadeusz Kondratowicz, Mateusz Cybińska, Joanna Stępień, Marcin
Published in
Angewandte Chemie (International ed. in English)
Peripheral substitution of a π-extended porphyrin with bulky groups produces a curved chromophore with four helical stereogenic units. The curvature and stereochemistry of such porphyrins can be controlled by varying the substituents, coordinated metal ions, and apical ligands. In particular, when the achiral saddle-shaped free bases are treated wi...
Wang, Changhao Qi, Qianqian Li, Wenying Dang, Jingshuang Hao, Min Lv, Shuting Dong, Xingchen Gu, Youkun Wu, Peizhe Zhang, Wenyue
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Published in
Nature Communications
