Zfp521 is essential for the quiescence and maintenance of adult hematopoietic stem cells under stress
...Published in iScience
Molecular Biology; Cell Biology; Stem Cell Research; Transcriptomics
Published in iScience
Molecular Biology; Cell Biology; Stem Cell Research; Transcriptomics
Published in iScience
Cell Biology; Stem Cell Research; Cancer
Published in iScience
Molecular Biology; Cell Biology; Stem Cell Research; Developmental Biology;
Published in iScience
Cell Biology; Stem Cell Research; Technical Aspects of Cell Biology
Published in iScience
Immunology; Immune Response; Virology; Stem Cell Research
Published in iScience
Neuroscience; Stem Cell Research
Published in iScience
Cell Biology; Stem Cell Research; Cancer
Head and neck squamous cell carcinomas (HNSCCs) are malignancies that originate in the mucosal lining of the upper aerodigestive tract. Despite advances in therapeutic interventions, survival rates among HNSCC patients have remained static for years. Cancer stem cells (CSCs) are tumor-initiating cells that are highly resistant to treatment, and are...
Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive, late in the action potential. NaV1.5 is SUMOylated only on lysine 442, and the mutation of that residue, or ...
Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications. The high similarity of organoid-derived retinal tissue and transplantable human fetal retina provides an opportunity for evaluating and modeling retinal tissu...