Zfp521 is essential for the quiescence and maintenance of adult hematopoietic stem cells under stress
...Published in iScience
Molecular Biology; Cell Biology; Stem Cell Research; Transcriptomics
Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells
Published in iScience
Cell Biology; Stem Cell Research; Cancer
Human pluripotent stem cell-derived DDX4 and KRT-8 positive cells participate in ovarian follicle-like structure formati...
Published in iScience
Molecular Biology; Cell Biology; Stem Cell Research; Developmental Biology;
Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal ...
Published in iScience
Cell Biology; Stem Cell Research; Technical Aspects of Cell Biology
Innate and Adaptive Immunity of Murine Neural Stem Cell-Derived piRNA Exosomes/Microvesicles against Pseudotyped SARS-Co...
Published in iScience
Immunology; Immune Response; Virology; Stem Cell Research
Syndecan-1 Stimulates Adult Neurogenesis in the Mouse Ventricular-Subventricular Zone after Injury
Published in iScience
Neuroscience; Stem Cell Research
Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and N...
Published in iScience
Cell Biology; Stem Cell Research; Cancer
Immunoregulatory Potential of Exosomes Derived from Cancer Stem Cells.
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Head and neck squamous cell carcinomas (HNSCCs) are malignancies that originate in the mucosal lining of the upper aerodigestive tract. Despite advances in therapeutic interventions, survival rates among HNSCC patients have remained static for years. Cancer stem cells (CSCs) are tumor-initiating cells that are highly resistant to treatment, and are...
Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels.
Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive, late in the action potential. NaV1.5 is SUMOylated only on lysine 442, and the mutation of that residue, or ...
Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue.
Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications. The high similarity of organoid-derived retinal tissue and transplantable human fetal retina provides an opportunity for evaluating and modeling retinal tissu...
