Yu, Shengpeng Jiang, Bei Jia, Chao Wu, Hongri Shen, Jie Hu, Xiaomei Xie, Zhao
Published in
Annals of Clinical Microbiology and Antimicrobials
BackgroundStaphylococcus aureus is a primary pathogen of orthopedic infections. By mediating antimicrobial resistance, S. aureus biofilm plays an important role in the recalcitrance of orthopedic infections, especially for the intractable osteomyelitis (OM). This study investigated the relationship between biofilm production and various genetic or ...
Xiao, Shuzhen Cui, Peng Shi, Wanliang Zhang, Ying
Published in
BMC Complementary Medicine and Therapies
BackgroundStaphylococcus aureus is the most dominant human pathogen, responsible for a variety of chronic and severe infections. There is mounting evidence that persisters are associated with treatment failure and relapse of persistent infections. While some essential oils were reported to have antimicrobial activity against growing S. aureus, acti...
Hardtstock, Fraence Heinrich, Kirstin Wilke, Thomas Mueller, Sabrina Yu, Holly
Published in
BMC Infectious Diseases
BackgroundThis study assessed incidence, risk factors, and outcomes of Staphylococcus aureus infections (SAI) following endoprosthetic hip or knee, or spine surgeries.MethodsAdult patients with at least one of the selected surgeries from 2012 to 2015 captured in a German sickness fund database were included. SAI were identified using S. aureus-spec...
Abdulgader, Shima M. Lentswe, Tshepiso Whitelaw, Andrew Newton-Foot, Mae
Published in
Antimicrobial Resistance & Infection Control
BackgroundAntimicrobial resistance is an increasingly serious problem in public health globally. Monitoring resistance levels within healthcare and community settings is critical to combat its ongoing increase. This study aimed to describe the rates and molecular mechanisms of mupirocin resistance in clinical Staphylococcus aureus isolates from Tyg...
Kumar, Pradeep
Published in
BMC Chemistry
Methicillin Resistant Staphylococcus aureus (MRSA) consists of strains of S. aureus which are resistant to methicillin. The resistance is due to the acquisition of mecA gene which encodes PBP2a unlike of any PBPs normally produced by S. aureus. PBP2a shows unusually low β-Lactam affinity and remains active to allow cell wall synthesis at normally l...
Macdonald, Katherine E. Jordan, Crispin Y. Crichton, Emma Barnes, Judith E. Harkin, Gillian E. Hall, Lesley M. L. Jones, Joshua D.
Published in
BMC Infectious Diseases
BackgroundThis study represents the first Scottish retrospective analysis of the microbiology of diabetic foot infections (DFIs). The aims were to compare the microbiological profile of DFIs treated at a Scottish tertiary hospital to that in the literature, gather data regarding antimicrobial resistance and investigate potential trends between the ...
Dian Permana, Andi Mir, Maria Utomo, Emilia Donnelly, Ryan F
Published in
International journal of pharmaceutics
The presence of bacterial biofilms in wounds is a main issue in the healing process. Conventional therapy of bacterial biofilms is hampered by the poor penetration of antibacterial agents through the physical barrier on the infected skin and the non-specific target of antibacterial agents. Here, we present a combination approach of bacterial sensit...
Ikemoto, Kana Kobayashi, Shinya Haranosono, Yu Kozai, Seiko Wada, Tomoyuki Tokushige, Hideki Kawamura, Akio
Published in
BMC Ophthalmology
BackgroundWe aimed to demonstrate the contribution of anti-inflammatory and anti-virulence effects of azithromycin (AZM) in ocular surface infection treatment.MethodsStaphylococcus aureus was injected into the corneal stroma of rabbits to induce keratitis. AZM at concentrations of 0.01, 0.1, and 1% was instilled into the eye twice daily. The eyes w...
Ning, Jintang Wang, Jimei Zhang, Songzhen Sha, Xiaojuan
Published in
The spine journal : official journal of the North American Spine Society
Nasal colonization of Staphylococcus aureus may increase the risk of surgical site infection (SSI) after spine surgeries, although the results of previous studies were inconsistent. To evaluate the influences of nasal colonization of S. aureus, methicillin-susceptible SA, and methicillin-resistant SA (MRSA) on the incidence of SSI after spine surge...
Ong, Jia Sin Taylor, Todd D Yong, Cheng Chung Khoo, Boon Yin Sasidharan, Sreenivasan Choi, Sy Bing Ohno, Hiroshi Liong, Min Tze
Published in
Probiotics and antimicrobial proteins
This study aimed to elucidate the targets and mechanisms of anti-staphylococcal effects from bioactive metabolites produced by lactic acid bacteria. We aimed to better understand the safety and efficacy of these bioactive metabolites in in vivo systems, typically at topical sites. The cell-free supernatant and protein-rich fraction from Lactobacill...
