Lallemand, Elodie Anne Zemirline, Claudine Toutain, Pierre-Louis Bousquet-Melou, Alain Ferran, Aude A. Boullier, Séverine
Published in
BMC Veterinary Research
BackgroundThe bactericidal activity of an antimicrobial drug is generally assessed by in vitro bacterial time-kill experiments which do not include any components of the immune system, even though the innate immunity, the primary host defence, is probably able to kill a large proportion of pathogenic bacteria in immunocompetent patients.We develope...
Hannachi, Nadji Fournier, Pierre-Edouard Martel, Hélène Habib, Gilbert Camoin-Jau, Laurence
Published in
Platelets
Platelets have largely demonstrated their implication in anti-infectious immunity. This effect is ensured by the secreted molecules stored mostly in platelet alpha granules. Previous studies have reported that Staphylococcus aureus showed sensitivity to this antibacterial effect of platelets. Statins, for their part, have shown a modulating effect ...
Wang, Honglei Chen, Chen Chen, Xiaojie Zhang, Jingju Liu, Yiming Li, Xiubo
Published in
Frontiers in Veterinary Science
Staphylococcus aureus (S. aureus) is a common pathogen that causes mastitis, an infection of the milk-secreting tissue of the udder, in dairy cows, and presents a huge economic problem for the dairy industry worldwide. Thus, control and treatment of mastitis in dairy cows is vital in order to reduce the costs associated with the disease. The main p...
Cruz, Ana Rita van Strijp, Jos A. G. Bagnoli, Fabio Manetti, Andrea G. O.
Published in
Frontiers in Microbiology
Staphylococcus aureus is the main cause of human skin and soft tissue infections. However, S. aureus pathogenicity within the skin is not fully characterized. Here, we implemented an S. aureus cutaneous infection model using human skin explants and performed a time-course infection to study the gene expression profile of a large panel of virulence-...
Haghi, Fakhri Zeighami, Habib Hajiloo, Zeynab Torabi, Neda Derakhshan, Safoura
Published in
Journal of Health, Population and Nutrition
BackgroundStaphylococcus aureus is recognized as an important cause of food poisoning related to the consumption of raw, undercooked, or mishandled foods worldwide.MethodsA total of 90 individual meat samples and 200 clinical specimens were collected and investigated the frequency of S. aureus and classical enterotoxin genes. The samples were cultu...
Wang, Jian Wang, Liucai
Published in
BMC Musculoskeletal Disorders
Septic arthritis (SA) represents a medical emergency that needs immediate diagnosis and urgent treatment. Despite aggressive treatment and rapid diagnosis of the causative agent, the mortality and lifelong disability, associated with septic arthritis remain high as close to 11%. Moreover, with the rise in drug resistance, the rates of failure of co...
Harrison, Zoe L. Awais, Rukhsana Harris, Michael Raji, Babatunde Hoffman, Brian C. Baker, Daniel L. Jennings, Jessica Amber
Published in
Frontiers in Microbiology
Fatty-acid signaling molecules can inhibit biofilm formation, signal dispersal events, and revert dormant cells within biofilms to a metabolically active state. We synthesized 2-heptylcyclopropane-1-carboxylic acid (2CP), an analog of cis-2-decenoic acid (C2DA), which contains a cyclopropanated bond that may lock the signaling factor in an active s...
De Pascale, Gennaro De Maio, Flavio Carelli, Simone De Angelis, Giulia Cacaci, Margherita Montini, Luca Bello, Giuseppe Cutuli, Salvatore Lucio Pintaudi, Gabriele Tanzarella, Eloisa Sofia
...
Published in
Critical Care
BackgroundHospitalized patients with COVID-19 admitted to the intensive care unit (ICU) and requiring mechanical ventilation are at risk of ventilator-associated bacterial infections secondary to SARS-CoV-2 infection. Our study aimed to investigate clinical features of Staphylococcus aureus ventilator-associated pneumonia (SA-VAP) and, if bronchoal...
Pang, Stanley Daley, Denise A Sahibzada, Shafi Mowlaboccus, Shakeel Stegger, Marc Coombs, Geoffrey W
Published in
BMC Genomics
BackgroundThe global emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has seen the dominance of specific clones in different regions around the world with the PVL-positive ST93-IV as the predominant CA-MRSA clone in Australia. In this study we applied a genome-wide association study (GWAS) approach on a collec...
Choi, Seong-Ho Dagher, Michael Ruffin, Felicia Park, Lawrence P Sharma-Kuinkel, Batu K Souli, Maria Morse, Alison M Eichenberger, Emily M Hale, Lauren Kohler, Celia
...
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
To understand the clinical, bacterial, and host characteristics associated with recurrent Staphylococcus aureus bacteremia (R-SAB), patients with R-SAB were compared to contemporaneous patients with a single episode of SAB (S-SAB). All SAB isolates underwent spa genotyping. All isolates from R-SAB patients underwent pulsed-field gel electrophoresis...
