Yang, Jing Tang, Xujiao Liang, Zhu Chen, Mingzhu Sun, Lixin
Published in
Clinical and molecular hepatology
Disrupted bile acid regulation and accumulation in the liver can contribute to progressive liver damage and fibrosis. However, the effects of bile acids on the activation of hepatic stellate cells (HSCs) remain unclear. This study investigated the effects of bile acids on HSC activation during liver fibrosis, and examined the underlying mechanisms....
Zhou, Caixia Kuang, Yashu Li, Qinyu Duan, Yunhao Liu, Xiuxiang Yue, Jinnan Chen, Xiaoli Liu, Jie Zhang, Yuzhen Zhang, Lin
...
Published in
Theranostics
Aims: It is important to understand the mechanism that regulates post-ischemic angiogenesis and to explore a new therapeutic target for an effective improvement of revascularization in peripheral artery disease (PAD) patients. Post-ischemic angiogenesis is a highly orchestrated process, which involves vascular endothelial cells (ECs) proliferation,...
Luo, Zonghua Liu, Hui Klein, Robyn S Tu, Zhude
Published in
Bioorganic & medicinal chemistry
Twenty eight new aryloxybenzene analogues were synthesized and their in vitro binding potencies toward S1PR2 were determined using a [32P]S1P competitive binding assay. Out of these new analogues, three compounds, 28c (IC50 = 29.9 ± 3.9 nM), 28e (IC50 = 14.6 ± 1.5 nM), and 28g (IC50 = 38.5 ± 6.3 nM) exhibited high binding potency toward S1PR2 and h...
Chen, Ruirui Cai, Xiqiang Liu, Jing Bai, Baobao Li, Xue
Published in
Life sciences
The sphingolipid metabolite sphingosine 1‑phosphate (S1P) has emerged as a potential cardioprotective molecule against ischemic heart disease. Moreover, S1P triggers mobilization and homing of bone marrow-derived stem/progenitor cells into the damaged heart. However, it remains elusive whether S1P promotes mesenchymal stem cells (MSCs)-mediated car...
Bruno, Gennaro Cencetti, Francesca Bernacchioni, Caterina Donati, Chiara Blankenbach, Kira Vanessa Thomas, Dominique Meyer Zu Heringdorf, Dagmar Bruni, Paola
Published in
Cellular signalling
Skeletal muscle tissue retains a remarkable regenerative capacity due to the activation of resident stem cells that in pathological conditions or after tissue damage proliferate and commit themselves into myoblasts. These immature myogenic cells undergo differentiation to generate new myofibers or repair the injured ones, giving a strong contributi...
Luo, Zonghua Yue, Xuyi Yang, Hao Liu, Hui Klein, Robyn S Tu, Zhude
Published in
Bioorganic & medicinal chemistry letters
Eleven new sphingosine 1-phosphate receptor 2 (S1PR2) ligands were synthesized by modifying lead compound N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide (JTE-013) and their binding affinities toward S1PRs were determined in vitro using [32P]S1P and cell membranes expressing recombinan...
Thiede-Stan, Nina K Tews, Björn Albrecht, David Ristic, Zorica Ewers, Helge Schwab, Martin E
Published in
Journal of cell science
To ensure precision and specificity of ligand-receptor-induced signaling, co-receptors and modulatory factors play important roles. The membrane-bound ligand Nogo-A (an isoform encoded by RTN4) induces inhibition of neurite outgrowth, cell spreading, adhesion and migration through multi-subunit receptor complexes. Here, we identified the four-trans...
Zhou, Huiping Hylemon, Phillip B
Published in
Steroids
Bile salts play crucial roles in allowing the gastrointestinal system to digest, transport and metabolize nutrients. They function as nutrient signaling hormones by activating specific nuclear receptors (FXR, PXR, Vitamin D) and G-protein coupled receptors [TGR5, sphingosine-1 phosphate receptor 2 (S1PR2), muscarinic receptors]. Bile acids and insu...
