Lindsay, Angus Baumann, Cory W. Rebbeck, Robyn T. Yuen, Samantha L. Southern, William M. Hodges, James S. Cornea, Razvan L. Thomas, David D. Ervasti, James M. Lowe, Dawn A.
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Published in
Skeletal Muscle
BackgroundDystrophin deficiency sensitizes skeletal muscle of mice to eccentric contraction (ECC)-induced strength loss. ECC protocols distinguish dystrophin-deficient from healthy, wild type muscle, and test the efficacy of therapeutics for Duchenne muscular dystrophy (DMD). However, given the large lab-to-lab variability in ECC-induced strength l...
Leermakers, Pieter A. Remels, Alexander H. V. Langen, Ramon C. J. Schols, Annemie M. W. J. Gosker, Harry R.
Published in
BMC Pulmonary Medicine
BackgroundBoth mitophagy, a selective mechanism for clearance of mitochondria, and mitochondrial biogenesis are key processes determining mitochondrial content and oxidative capacity of the musculature. Abnormalities in these processes could therefore contribute to deterioration of peripheral muscle oxidative capacity as observed in e.g. chronic ob...
Mármol-Sánchez, Emilio Ramayo-Caldas, Yuliaxis Quintanilla, Raquel Cardoso, Tainã Figueiredo González-Prendes, Rayner Tibau, Joan Amills, Marcel
Published in
Journal of Animal Science and Biotechnology
BackgroundThe role of non-coding RNAs in the porcine muscle metabolism is poorly understood, with few studies investigating their expression patterns in response to nutrient supply. Therefore, we aimed to investigate the changes in microRNAs (miRNAs), long intergenic non-coding RNAs (lincRNAs) and mRNAs muscle expression before and after food intak...
Yousuf, Yusef Datu, Andrea Barnes, Ben Amini-Nik, Saeid Jeschke, Marc G.
Published in
Stem Cell Research & Therapy
BackgroundProfound skeletal muscle wasting and weakness is common after severe burn and persists for years after injury contributing to morbidity and mortality of burn patients. Currently, no ideal treatment exists to inhibit muscle catabolism. Metformin is an anti-diabetic agent that manages hyperglycemia but has also been shown to have a benefici...
Avila-Medina, Javier Mayoral-González, Isabel Galeano-Otero, Isabel Redondo, Pedro C Rosado, Juan A Smani, Tarik
Published in
Advances in experimental medicine and biology
Store-Operated Ca2+ Entry (SOCE) is an important Ca2+ influx pathway expressed by several excitable and non-excitable cell types. SOCE is recognized as relevant signaling pathway not only for physiological process, but also for its involvement in different pathologies. In fact, independent studies demonstrated the implication of essential protein r...
Ahmed, Fozia Chehadé, Lucia Garneau, Léa Caron, Audrey Aguer, Céline
Published in
Molecular and cellular endocrinology
Bisphenol A (BPA) is an environmental pollutant that has been associated with adverse health effects including skeletal muscle insulin resistance, a major contributor to the pathogenesis of type 2 diabetes (T2D). Early mitochondrial dysfunction and oxidative stress are linked to impaired glucose metabolism in skeletal muscle. In this study, we inve...
Wang, Qiu-Ying Tong, Ai-Hua Pan, Ying-Ying Zhang, Xian-Dang Ding, Wen-Yu Xiong, Wen
Published in
Diabetology & Metabolic Syndrome
BackgroundThis study aimed to observe the hypoglycemic effect of cassia seed extract in rats with type-2 diabetes mellitus and its effect on reducing insulin resistance in the skeletal muscle.Methods50 rats were randomly divided into the normal, model, high-dose, middle-dose, and low-dose groups of cassia seed extract (n = 10 each). A high-fat diet...
Makanae, Yuhei Ato, Satoru Kido, Kohei Fujita, Satoshi
Published in
Journal of the International Society of Sports Nutrition
BackgroundUrsolic acid altered muscle protein metabolism in normal and resting conditions after acute resistance exercise, suggesting that eating fruits rich in ursolic acid could enhance muscle protein synthesis and decrease muscle degradation. Aronia melanocarpa, a member of the family Rosaceae and native to North America and Eastern Canada, is r...
Croissant, Coralie
Les dystrophies musculaires sont un groupe de pathologies génétiques qui cause une faiblesse et une perte progressive des muscles squelettiques. Parmi elles, la dystrophie des ceintures de type 2B (LGMD2B) est caractérisée par des mutations dans le gène de la dysferline, entrainant de sévères dysfonctionnements, dont un défaut de réparation membran...
Welch, A A Jennings, A Kelaiditi, E Skinner, J Steves, C J
Published in
Calcified tissue international
The prevalence of sarcopenia is increasing in aging populations, so prevention is critical. Vitamins (A, C, E and carotenoids) modify skeletal muscle via protein and collagen synthesis and anti-inflammatory activities. Previous studies have not investigated intake of these vitamins in relation to sarcopenic indices in both younger and older-aged wo...
