Sartori, Roberta Romanello, Vanina Sandri, Marco
Published in
Nature Communications
Loss of muscle mass is associated with ageing and with a number of diseases such as cancer. Here, the authors review the signaling pathways that modulate protein synthesis and degradation and gain or loss of muscle mass, and discuss therapeutic implications and future directions for the field.
Deshmukh, A. S. Steenberg, D. E. Hostrup, M. Birk, J. B. Larsen, J. K. Santos, A. Kjøbsted, R. Hingst, J. R. Schéele, C. C. Murgia, M.
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Published in
Nature Communications
Skeletal muscle conveys the beneficial effects of physical exercise but due to its heterogeneity, studying the effects of exercise on muscle fibres is challenging. Here, the authors carry out proteomic analysis of myofibres from freeze-dried muscle biopsies, show fibre-type specific changes in response to exercise, and show that the oxidative and g...
Zanardi, Ana Paula Janner da Silva, Edson Soares Costa, Rochelle Rocha Passos-Monteiro, Elren dos Santos, Ivan Oliveira Kruel, Luiz Fernando Martins Peyré-Tartaruga, Leonardo Alexandre
Published in
Scientific Reports
We systematically reviewed observational and clinical trials (baseline) studies examining differences in gait parameters between Parkinson’s disease (PD) in on-medication state and healthy control. Four electronic databases were searched (November-2018 and updated in October-2020). Independent researchers identified studies that evaluated gait para...
Derstine, Brian A. Holcombe, Sven A. Ross, Brian E. Wang, Nicholas C. Su, Grace L. Wang, Stewart C.
Published in
Scientific Reports
Measurements of skeletal muscle cross-sectional area (SMA) at the level of the third lumbar (L3) vertebra derived from clinical computed tomography (CT) scans are commonly used in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging. As SMA is correlated with height and Body Mass Index (BMI), body size adju...
Ohyama, Shoichiro Hoshino, Masatoshi Takahashi, Shinji Hori, Yusuke Yasuda, Hiroyuki Terai, Hidetomi Hayashi, Kazunori Tsujio, Tadao Kono, Hiroshi Suzuki, Akinobu
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Published in
Scientific Reports
Sarcopenia has been associated with poor clinical outcomes in several diseases. Herein, the clinical results of balloon kyphoplasty (BKP) for acute osteoporotic vertebral fracture (OVF) treatment were assessed and compared between sarcopenia and non-sarcopenia patients. Sixty patients who underwent BKP for treatment of acute OVF with poor prognosti...
Ohori, Katsuhiko Yano, Toshiyuki Katano, Satoshi Kouzu, Hidemichi Honma, Suguru Shimomura, Kanako Inoue, Takuya Takamura, Yuhei Nagaoka, Ryohei Koyama, Masayuki
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Published in
BMC Geriatrics
BackgroundAlthough high body mass index (BMI) is a risk factor of heart failure (HF), HF patients with a higher BMI had a lower mortality rate than that in HF patients with normal or lower BMI, a phenomenon that has been termed the “obesity paradox”. However, the relationship between body composition, i.e., fat or muscle mass, and clinical outcome ...
McGrath, Meagan J. Eramo, Matthew J. Gurung, Rajendra Sriratana, Absorn Gehrig, Stefan M. Lynch, Gordon S. Lourdes, Sonia Raveena Koentgen, Frank Feeney, Sandra J. Lazarou, Michael
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Published in
The Journal of Clinical Investigation
Fernández-Torres, Javier Martínez-Nava, Gabriela Angélica Zamudio-Cuevas, Yessica Barbier, Olivier Christophe Narváez-Morales, Juana Martínez-Flores, Karina
Published in
Clinical rheumatology
Articular cartilage and periarticular muscle tissues are strongly affected during knee osteoarthritis (OA). Creatine kinase (CK) is an enzyme expressed in several tissues, but the isoform CK-MM is specific of skeletal muscle, and its serum concentration is used as a biomarker of muscle damage. Genetic variants of the CKM gene have been associated w...
Kourakis, Stephanie Timpani, Cara A de Haan, Judy B Gueven, Nuri Fischer, Dirk Rybalka, Emma
Published in
Redox biology
Imbalances in redox homeostasis can result in oxidative stress, which is implicated in various pathological conditions including the fatal neuromuscular disease Duchenne Muscular Dystrophy (DMD). DMD is a complicated disease, with many druggable targets at the cellular and molecular level including calcium-mediated muscle degeneration; mitochondria...
Hettinger, Zachary R Confides, Amy L Vanderklish, Peter W Sidhom, Silvana Masternak, Michal M Dupont-Versteegden, Esther E
Published in
Experimental gerontology
RNA binding protein motif 3 (RBM3) is an RNA-binding and cold shock protein that protects myoblasts and promotes skeletal muscle hypertrophy by enhancing mRNA stability and translation. Muscle size is decreased during aging; however, it is typically delayed in models of extended lifespan such as the long-lived Ames Dwarf (df/df) mice and calorie re...