Published in Epigenetics
In addition to multi-nucleated muscle fibres, numerous resident and infiltrating mononuclear cells populate the muscle compartment. As most epigenetic assays in skeletal muscle are conducted on whole tissue homogenates, essentially nothing is known about regulatory processes exclusively within muscle fibres in vivo. Utilizing a novel genetically mo...
Published in International Journal of Molecular Sciences
Skeletal muscle has a remarkable plasticity, and its phenotype is strongly influenced by hormones, transcription factors, and physical activity. However, whether skeletal phenotype can be oriented or not during early embryonic stages has never been investigated. Here, we report that pyruvate as the only source of carbohydrate in the culture medium ...
Published in Journal of biomechanics
Extracellular matrix (ECM) is widely considered to be integral to the function of skeletal muscle, providing mechanical support, transmitting force, and contributing to passive stiffness. Many functions and dysfunctions attributed to ECM are thought to stem from its mechanical properties, yet there are few data describing the mechanics of intact EC...
Published in American journal of physiology. Cell physiology
The role of dysregulated intracellular creatine metabolism in disuse atrophy is unknown. In this study, skeletal muscle biopsy samples were obtained after 7-days of unilateral leg immobilization (IMMOB) and the non-immobilized control limb (CTRL) of 15 healthy males (23.1 ± 3.5 yrs). Samples were analyzed for fibre-type cross-sectional area (CSA) a...
Published in International journal of obesity (2005)
Impaired insulin-mediated glucose partitioning is an intrinsic metabolic defect in skeletal muscle from severely obese humans (BMI ≥ 40 kg/m2). Roux-en-Y gastric bypass (RYGB) surgery has been shown to improve glucose metabolism in severely obese humans. The purpose of the study was to determine the effects of RYGB surgery on glucose partitioning, ...
Published in Physical Therapy Research
Malnutrition is a common complication in patients with tongue cancer who experience dysphagia and can steadily lead to skeletal muscle atrophy. Additionally, skeletal muscle loss commonly occurs in patients after invasive surgery. Therefore, patients with tongue cancer are at high risk of skeletal muscle atrophy during the perioperative phase of tr...
Published in Journal of proteome research
Heterogeneity in skeletal muscle contraction time, peak power output, and resistance to fatigue, among others, is necessary to accommodate the wide range of functional demands imposed on the body. Underlying this functional heterogeneity are a myriad of differences in the myofilament protein isoform expression and post-translational modifications; ...
Abstract Introduction: Professional and recreational athletes make daily use of nutritional supplements to improve physical performance. Polyunsaturated fatty acids (PUFAs) have been used in this sense. N-3 PUFA, particularly eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids are involved in important physiological functions and the benefits of...
Published in Plastic and reconstructive surgery
Published in Journal of Musculoskeletal & Neuronal Interactions
Objective: This study aimed to evaluate changes in i) muscle contractile properties of both lower extremities by using tensiomyography (TMG); ii) patients’ physical function, and iii) electromechanical efficiency (EME) of the gastrocnemius medialis muscle in total knee arthroplasty (TKA) patients from before to one-month after TKA. Methods: Twenty-...
