Spinler, Kyle Bajaj, Jeevisha Ito, Takahiro Zimdahl, Bryan Hamilton, Michael Ahmadi, Armin Koechlein, Claire S Lytle, Nikki Kwon, Hyog Young Anower-E-Khuda, Ferdous
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Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus, identifying the cells responsible for residual disease and leukemia re-growth is critical to better understanding how they are regulated. Here, we show that a knock-in reporter mouse for the stem cell gene Musas...
Tunbak, Hale Enriquez-Gasca, Rocio Tie, Christopher HC Gould, Poppy A Mlcochova, Petra Gupta, Ravindra Fernandes, Liane Holt, James van der Veen, Annemarthe G Giampazolias, Evangelos
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Stilhano, Roberta Sessa Costa, Angelica Jardim Nishino, Michelle Sayuri Shams, Shahin Bartolomeo, Cynthia Silva Breithaupt-Faloppa, Ana Cristina Silva, Eduardo Alexandre Ramirez, Ana Lopez Prado, Carla Maximo Ureshino, Rodrigo Portes
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has provoked major stresses on the health-care systems of several countries, and caused the death of more than a quarter of a million people globally, mainly in the elderly population with preexisting pathologies. Previous studies with coronavirus (SARS-CoV) point to gender d...
Hultgren, Nan W Fang, Jennifer S Ziegler, Mary E Ramirez, Ricardo N Phan, Duc TT Hatch, Michaela MS Welch-Reardon, Katrina M Paniagua, Antonio E Kim, Lin S Shon, Nathan N
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Slug (SNAI2), a member of the well-conserved Snail family of transcription factors, has multiple developmental roles, including in epithelial-to-mesenchymal transition (EMT). Here, we show that Slug is critical for the pathological angiogenesis needed to sustain tumor growth, and transiently necessary for normal developmental angiogenesis. We find ...
Yu, Chaojie Zhan, Xinli Liu, Chong Zhang, Zide Jiang, Jie Xu, Guoyong Xue, Jiang
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Ankylosing spondylitis (AS) is a disease that causes pathological changes in the spine and sacroiliac joints. Numerous studies have shown that the characteristics of AS differ between males and females. The purpose of this study was to discover the key molecules that contribute to sex-associated differences in AS, which may provide a new...
Yao, Catherine D Haensel, Daniel Gaddam, Sadhana Patel, Tiffany Atwood, Scott X Sarin, Kavita Y Whitson, Ramon J McKellar, Siegen Shankar, Gautam Aasi, Sumaira
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Tumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to targeted cancer therapies. Basal cell carcinomas (BCCs) depend on Hedgehog (Hh)/Gli signaling, but can develop mechanisms of Smoothened (SMO) inhibitor resistance. We previously identified a nuclear myocardin-related transcription factor (nMRTF) resistance pat...
Ren, Shuling Gaykalova, Daria A Guo, Theresa Favorov, Alexander V Fertig, Elana J Tamayo, Pablo Callejas-Valera, Juan Luis Allevato, Mike Gilardi, Mara Santos, Jessica
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The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype with increase in expression of E2...
Wang, Shixiong Somisetty, Venkata S Bai, Baoyan Chernukhin, Igor Niskanen, Henri Kaikkonen, Minna U Bellet, Meritxell Carroll, Jason Hurtado, Antoni
Candas-Green, Demet Xie, Bowen Huang, Jie Fan, Ming Wang, Aijun Menaa, Cheikh Zhang, Yanhong Zhang, Lu Jing, Di Azghadi, Soheila
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Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, the immunosuppressive factors induced by radiation on tumor cells remain to be identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast cancer (BC) cells and RT-treated mouse syngeneic B...
Brami-Cherrier, Karen Lewis, Robert G Cervantes, Marlene Liu, Yu Tognini, Paola Baldi, Pierre Sassone-Corsi, Paolo Borrelli, Emiliana
Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal pathways implicated have not been fully elucidated. Addictive drugs, such as cocaine, induce a rapid increase of dopamine levels in the brain. Here, we show that acute administration of cocaine triggers reprogramming in circadian gene expres...