PHLDA3 (Pleckstrin Homology-Like Domain, family A, member 3)
Review on PHLDA3, with data on DNA, on the protein encoded, and where the gene is implicated.
BUB3 (BUB3 mitotic checkpoint protein)
BUB3 is a WD40 protein that belongs to spindle mitotic checkpoint complex, which monitors the chromosome attachment to mitotic (or meiotic) fuse and prevents premature chromosome segregation. Alterations in BUB3 have been associated with chromosomal instability and aneuploidy, but their contribution for cancer development and progression are poorly...
t(1;1)(q24;q25) RCSD1/ABL2::inv(1)(q24q25) RCSD1/ABL2
Review on t(1;1)(q24;q25)/inv(1)(q24q25), with data on clinics, and the genes involved.
Artificial Transmembrane Signalling
EPSRC, Trinity College Cambridge, Department of Chemistry
Genome-wide Kdm4 histone demethylase transcriptional regulation in Drosophila.
The histone lysine demethylase 4 (Kdm4/Jmjd2/Jhdm3) family is highly conserved across species and reverses di- and tri-methylation of histone H3 lysine 9 (H3K9) and lysine 36 (H3K36) at the N-terminal tail of the core histone H3 in various metazoan species including Drosophila, C.elegans, zebrafish, mice and humans. Previous studies have shown that...
Gene Ontology Causal Activity Modeling (GO-CAM) moves beyond GO annotations to structured descriptions of biological fun...
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Mechanisms of microparticle release from human platelets
Platelets release a variety of extracellular vesicles, including platelet-derived microparticles that expose phosphatidylserine on their surface. This thesis aims to resolve the mechanisms by which pro-thrombotic microparticles are released from platelets, which have not been well-characterised. Experimental methods used include flow cytometry, Wes...
Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to...
...Published in Gastroenterology
Most pancreatic ductal adenocarcinomas (PDACs) express an activated form of KRAS, become hypoxic and dysplastic, and are refractory to chemo and radiation therapies. To survive in the hypoxic environment, PDAC cells upregulate enzymes and transporters involved in pH regulation, including the extracellular facing carbonic anhydrase 9 (CA9). We evalu...
Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice.
...Published in Gastroenterology
The role of aryl hydrocarbon receptor (AhR) in liver fibrosis is controversial because loss and gain of AhR activity both lead to liver fibrosis. The goal of this study was to investigate how the expression of AhR by different liver cell types, hepatic stellate cells (HSCs) in particular, affects liver fibrosis in mice. We studied the effects of Ah...
NOTCH Activation Promotes Valve Formation by Regulating the Endocardial Secretome.
Published in Molecular & cellular proteomics : MCP
The endocardium is a specialized endothelium that lines the inner surface of the heart. Functional studies in mice and zebrafish have established that the endocardium is a source of instructive signals for the development of cardiac structures, including the heart valves and chambers. Here, we characterized the NOTCH-dependent endocardial secretome...
