Targeting B cell malignancies through human B cell receptor specific CD4 T cells
...Published in Journal for ImmunoTherapy of Cancer
IL2RA is associated with persistence of rheumatoid arthritis
Published in Arthritis Research & Therapy
IntroductionAlthough rheumatoid arthritis (RA) is generally a chronic disease, a proportion of RA-patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission, reflecting loss of disease-persistence. To explore mechanisms underlying RA-persistence, we performed a candidate gene study. We hypothesized that variants associat...
Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study
...Published in Arthritis Research & Therapy
IntroductionApproximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms could explain part of the remaining heritability. Multiple interactions have been reported, but only the shared epitope (SE) × protein tyrosi...
Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid ...
...Published in Arthritis Research & Therapy
IntroductionGenetic susceptibility to complex diseases has been intensively studied during the last decade, yet only signals with small effect have been found leaving open the possibility that subgroups within complex traits show stronger association signals. In rheumatoid arthritis (RA), autoantibody production serves as a helpful discriminator in...
How citrullination invaded rheumatoid arthritis research
Published in Arthritis Research & Therapy
Citrullination and the immune response to citrullinated proteins have been fundamental for the early recognition of rheumatoid arthritis by serological tests and a better understanding of its pathophysiology. In the first years after the initial publications, the focus was on the antibodies directed to citrullinated proteins. It is now realized tha...
Lack of HLA predominance and HLA shared epitopes in biliary Atresia
Published in SpringerPlus
Biliary atresia (BA) is characterized by progressive inflammation and fibrosis of bile ducts. A theory of pathogenesis entails autoimmune-mediated injury targeting bile duct epithelia. One of the strongest genetic associations with autoimmunity is with HLA genes. In addition, apparently dissimilar HLA alleles may have similar antigen-binding sites,...
Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease
Published in Arthritis Research & Therapy
IntroductionThe largest genetic risk to develop rheumatoid arthritis (RA) arises from a group of alleles of the HLA DRB1 locus ('shared epitope', SE). Over 30 non-HLA single nucleotide polymorphisms (SNPs) predisposing to disease have been identified in Caucasians, but they have never been investigated in West/Central Africa. We previously reported...
Comparison of the neutralization sensitivity of South African and Indian HIV-1 subtype C viruses to South African plasma...
Published in Retrovirology
Production and expression of recombinant anti-V3 scFvs from HIV-1 clade C infected Indian patient
...Published in Retrovirology
Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheuma...
...Published in Arthritis Research & Therapy
IntroductionRheumatoid arthritis (RA) is a multifactorial autoimmune disease in which genetic and environmental factors interact in the etiology. In this study, we investigated whether smoking and HLA-DRB1 shared-epitope (SE) alleles interact differently in the development of the two major subgroups of rheumatoid arthritis (RA), anti-citrullinated ...
