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Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling.

Published in Proceedings of the National Academy of Sciences of the United States of America

Coordinated metabolic reprogramming and epigenetic remodeling are critical for modulating T cell function and differentiation. However, how the epigenetic modification controls Th17/Treg cell balance via metabolic reprogramming remains obscure. Here, we find that Setd2, a histone H3K36 trimethyltransferase, suppresses Th17 development but promotes ...

Setd5, but not Setd2, is indispensable for retinal cell survival and proliferation.

Published in FEBS letters

Trimethylation of histone H3 at lysine 36 (H3K36me3) is associated with active transcription. We used mouse retinal explant cultures and shRNA to investigate the roles of Setd2 and Setd5, which encode H3K36me3 methyltransferases, in retinal development. We found that shSetd5 caused abnormal retinal structures and reduced rods and Müller cells, wher...

Caractérisation structurale et fonctionnelle de mutations oncogéniques de l'histone méthyltransférase SETD2 et de l'hist...

Chez l'Homme, SET Domain containing 2 (SETD2) est la principale histone méthyltransférase responsable de la triméthylation de la lysine 36 de l'histone H3 (H3K36) pour donner la marque épigénétique H3K36me3. Cette enzyme fait partie de la famille des histone méthyltransférases à domaine SET et catalyse le transfert d'un groupe méthyl sur la lysine ...

The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential...

Published in The Journal of Biological Chemistry

Spermatogenesis is precisely controlled by complex gene expression programs and involves epigenetic reprogramming, including histone modification and DNA methylation. SET domain–containing 2 (SETD2) is the predominant histone methyltransferase catalyzing the trimethylation of histone H3 lysine 36 (H3K36me3) and plays key roles in embryonic stem cel...

Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts.

Published in Biochimica et biophysica acta. Molecular cell research

Skeletal muscle cell proliferation and differentiation are tightly regulated. Epigenetic regulation is a major component of the regulatory mechanism governing these processes. Histone modification is part of the epigenetic code used for transcriptional regulation of chromatin through the establishment of an active or repressive state for genes invo...

CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantat...

Published in Developmental biology

Genome-wide epigenetic reprogramming is required for successful preimplantation development. Inappropriate or deficient chromatin regulation can result in defective lineage specification and loss of genomic imprinting, compromising normal development. Here we report that two members of the RNA polymerase II associated factor, homolog (Saccharomyces...