Chen, Zhijie Lin, Yingbo Zhou, Qichun Xiao, Shilin Li, Chan Lin, Rukun Li, Jing Chen, Yifei Luo, Chaohua Mo, Zhixian
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Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Morphine dependence, a devastating neuropsychiatric condition, may be closely associated with gut microbiota dysbiosis. Ginsenoside Rg1 (Rg1), an active ingredient extracted from the roots of Panax ginseng C.A. Meyer, has potential health-promoting effects on the nervous system. However, its role in substance use disorders remains unclear. Here, we...
Cattarinussi, Giulia Delvecchio, Giuseppe Moltrasio, Chiara Ferro, Adele Sambataro, Fabio Brambilla, Paolo
Published in
Journal of affective disorders
Borderline personality disorder (BPD) is a serious mental condition characterized by instability in identity, interpersonal relationships, emotion regulation and impulsivity. These symptoms seem to be associated to specific brain alterations, which have been largely investigated. In particular, positron emission tomography (PET) and functional near...
Carranza-Aguilar, César J Hernández-Mendoza, Araceli Mejias-Aponte, Carlos Rice, Kenner C Morales, Marisela González-Espinosa, Claudia Cruz, Silvia L
Published in
Cellular and molecular neurobiology
Morphine promotes neuroinflammation after NOD-like receptor protein 3 (NLRP3) oligomerization in glial cells, but the capacity of other opioids to induce neuroinflammation and its relationship to the development of analgesic tolerance is unknown. We studied the effects of morphine and fentanyl on NLRP3 inflammasome activation in glial and neuronal ...
Mujagic, Z Kasapi, M Jonkers, DMAE Garcia Perez, I Vork, L Weerts, ZZRM Serrano Contreras, JI Zhernakova, A Kurilshikov, A Scotcher, J
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To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS) several modalities of biological and clinical data must be combined. We aimed to identify profiles of faecal microbiota and metabolites associated with IBS and to delineate specific phenotypes of IBS that represent potential pathophysiological mechanisms. F...
Ruyak, Sharon L Noor, Shahani DiDomenico, Jared Sun, Melody S Fernandez Oropeza, Annette K Rodriguez, Dominique E Marquez, Lidia Enriquez Milligan, Erin D Bakhireva, Ludmila N
Published in
Experimental neurology
Opioids and alcohol impact critical serotonin (5-HT) function in the developing placenta and fetus through the actions of immune proinflammatory factors. Yet, possible convergent effects of opioids and alcohol on human placental toll-like receptor 4 (TLR4) activation and subsequent 5-HT homeostasis remain entirely unknown. The purpose of this study...
Zaręba, Przemysław Śliwa, Paweł Satała, Grzegorz Zajdel, Paweł Latacz, Gniewomir Jaśkowska, Jolanta
Published in
European journal of medicinal chemistry
The 5-HT1A receptors are an important biological target in the treatment of CNS diseases. Recently, their importance in the context of non-CNS disease entities has also been postulated. In the light of these reports, we designed a new group of urea derivatives of N-aryl-N'-aryl-/(thio)ureido-/sulfamoylamino-derivatives of alkyl/alkylcarbamoyl piper...
Biserova, Natalia M Mustafina, Alfia R Raikova, Olga I
Published in
Zoology (Jena, Germany)
А novel type of a complex neuro-glandular brain structure including both nervous and glandular elements and associated with sensory ones is detected in Pyramicocephalus phocarum plerocercoid (Cestoda: Diphyllobothriidea), parasite of Gadus morua from the White Sea. The brain has two lateral lobes connected by a long cellular median commissure. The ...
Nirogi, Ramakrishna Abraham, Renny Jayarajan, Pradeep Goura, Venkatesh Kallepalli, Rajesh Medapati, Rajesh Babu Tadiparthi, Jayaprakash Goyal, Vinod Kumar Pandey, Santosh Kumar Subramanian, Ramkumar
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Published in
Psychopharmacology
Ropanicant (SUVN-911) (3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo (3.1.0) hexane hydrochloride) is a novel α4β2 nicotinic acetylcholine receptor (nAChR) antagonist being developed for the treatment of depressive disorders. Pharmacological and neurochemical characterization of Ropanicant to support a potential molecule for the treatment of depr...
Santos, Gabriela Xavier Barbosa, Danillo de-Souza, Giovane Galdino Kosour, Carolina Parizotto, Nivaldo Antonio Dos Reis, Luciana Maria
Published in
Lasers in medical science
This study aimed to investigate the central involvement of 5-HT1A receptors in the nociceptive behavior of mice submitted to the chronic constriction injury (CCI) of sciatic nerve and the subsequent application of photobiomodulation (PBM). Male mice (Swiss-albino) were submitted to CCI and subsequently received an infusion of WAY100635 (5-HT1A rece...
Tatsuoka, Misa Osaki, Yosuke Ohsaka, Fumina Tsuruta, Takeshi Kadota, Yoshihiro Tochio, Takumi Hino, Shingo Morita, Tatsuya Sonoyama, Kei
Published in
The British journal of nutrition
SCFA increase serotonin (5-hydroxytryptamine, 5-HT) synthesis and content in the colon in vitro and ex vivo, but little is known in vivo. We tested whether dietary indigestible saccharides, utilised as a substrate to produce SCFA by gut microbiota, would increase colonic 5-HT content in mice. Male C57BL/6J mice were fed a purified diet and water su...
