Farfariello, Valerio Gordienko, Dmitri V. Mesilmany, Lina Touil, Yasmine Germain, Emmanuelle Fliniaux, Ingrid Desruelles, Emilie Gkika, Dimitra Roudbaraki, Morad Shapovalov, George
...
Published in
Nature Communications
Mitochondrial Ca2+ homeostasis is reported to influence cellular senescence. Here the authors show that TRPC3 limits senescence by inhibiting IP3R-mediated Ca2+ release and ER mitochondria Ca2+ transfer and that the downregulation of TRPC3 in stromal cells affects SASP production and tumour progression.
Fan, Pan Yu, Xiao-Yu Chen, Chang-Hong Gao, Jia-Wei Xu, Yu-Zhu Xie, Xin-Hui Wang, Yun-Tao
Published in
Experimental gerontology
Bone marrow mesenchymal stem cells (BMSCs) have been investigated as cellular therapeutics for intervertebral disc degeneration. However, transplanted BMSCs are prone to be damaged. TNF-α is reported to extensively promote degeneration process. Nevertheless, the relationship between BMSCs senescence and TNF-α-induced stress has not been elucidated....
Carroll, Amber Desforges, Michelle Jones, Carolyn J P Heazell, Alexander E P
Published in
Placenta
Prolonged pregnancy describes a pregnancy that progresses beyond 42 weeks' gestation (294 days). In humans, prolonged pregnancy is associated with increasing perinatal mortality, neonatal compromise and birth by Caesarean section. The underpinning reasons behind these increased risks are unknown; one potential explanation is reduced placental funct...
Sadoughi, Baptiste Schneider, Dominik Daniel, Rolf Schülke, Oliver Ostner, Julia
Published in
Microbiome
Background Pronounced heterogeneity of age trajectories has been identified as a hallmark of the gut microbiota in humans and has been explained by marked changes in lifestyle and health condition. Comparatively, age-related personalization of microbiota is understudied in natural systems limiting our comprehension of patterns observed in humans fr...
Andreu-Sánchez, Sergio Aubert, Geraldine Ripoll-Cladellas, Aida Henkelman, Sandra Zhernakova, Daria V. Sinha, Trishla Kurilshikov, Alexander Cenit, Maria Carmen Jan Bonder, Marc Franke, Lude
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Published in
Communications Biology
Deep molecular and phenotypic data highlights the links of human telomere lengths from six different blood cells with genetics, parental phenotypes mediated by epigenetic signals and expression changes at the single cell level.
Cai, Guangping Xiao, Ye Yang, Mi Guo, Qi Su, Tian Liu, Yalin Jiang, Tiejian Li, Chun
Published in
PeerJ
Background Long noncoding RNA Gm31629 can regulate hypothalamic neural stem cells (htNSCs) senescence and the aging process. However, the effect of Gm31629 on the senescence of bone marrow mesenchymal stem cells (BMSCs) and bone regeneration is unclear. In the present study, we investigated the effects of Gm31629 on the senescence of BMSCs and bone...
Keow, Jonathan Cecchini, Matthew J. Jayawardena, Nathashi Zompatori, Maurizio Joseph, Mariamma G. Mura, Marco
Published in
Respiratory Research
Background Idiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and subsequent induction of cell cycle arrest, cellular senescence, and pro-fibrotic gene expression. We sought to link p16-expression with a diagnosis of IPF or other fibrotic interstitial lung diseases ...
Miura, Yugo Endo, Kentaro Komori, Keiichiro Sekiya, Ichiro
Published in
Stem Cell Research & Therapy
Background Osteoarthritis (OA) is an age-related joint disease characterized by progressive cartilage loss. Synovial mesenchymal stem cells (MSCs) are anticipated as a cell source for OA treatment; however, synovial MSC preparations isolated from OA patients contain many senescent cells that inhibit cartilage regeneration through their senescence-a...
Jiao, Defeng Zheng, Xiaohu Du, Xianghui Wang, Dong Hu, Ziming Sun, Rui Tian, Zhigang Fu, Binqing Wei, Haiming
Published in
Cancer immunology, immunotherapy : CII
The higher immunogenicity of tumors usually predicts favorable therapeutic responses. Tumor antigens dominate the immunogenic character within tumors. We investigated if there was a targetable tumor antigen during immunogenic chemotherapy within lung cancer. Chemotherapy-induced immunogenic senescence was demonstrated using a multi-marker, three-st...
Saleh, Tareq Carpenter, Valerie J Bloukh, Sarah Gewirtz, David A
Published in
Seminars in cancer biology
Senescence is a unique state of growth arrest that develops in response to a plethora of cellular stresses, including replicative exhaustion, oxidative injury, and genotoxic insults. Senescence has been implicated in the pathogenesis of multiple aging-related pathologies, including cancer. In cancer, senescence plays a dual role, initially acting a...