Rabier, Robin Lesobre, Loïc Robert, Alexandre
Published in
Scientific Reports
Although captive breeding programs are valuable for conservation, they have been shown to be associated with genetic changes, such as adaptation to captivity or inbreeding. In addition, reproductive performance is strongly age-dependent in most animal species. These mechanisms that potentially impact reproduction have often been studied separately,...
Jiang, Guo-Jian Li, Bei-Bei Fan, Ting-Jun
Published in
Life sciences
Limbal stem cells (LSCs) are crucial for corneal transparency and vision. Any damages to LSCs might lead to limbal stem cell deficiency resulting in corneal opacification and even blindness. Here, we investigated the cytotoxicity of timolol and its underlying mechanisms in rabbit LSCs (rLSCs) in vitro. High concentrations of 0.5% and 0.25% timolol ...
Kantapan, Jiraporn Paksee, Siwaphon Duangya, Aphidet Sangthong, Padchanee Roytrakul, Sittiruk Krobthong, Sucheewin Suttana, Wipob Dechsupa, Nathupakorn
Published in
BMC Complementary Medicine and Therapies
BackgroundRadioresistance can pose a significant obstacle to the effective treatment of breast cancers. Epithelial–mesenchymal transition (EMT) is a critical step in the acquisition of stem cell traits and radioresistance. Here, we investigated whether Maprang seed extract (MPSE), a gallotannin-rich extract of seed from Bouea macrophylla Griffith, ...
Kang, Kai Xia, Anran Meng, Fanrui Chunyu, Jian Sun, Xu Ren, Guiping Yu, Dan Jiang, Xinghao Tang, Lei Xiao, Wei
...
Published in
International immunopharmacology
Previous studies reported that FGF21 prolongs life span and delays the body senescence, but the mechanism is not clear. The present study was designed to investigate the effects of FGF21 on hepatic senescence in aging mice and further research the mechanism. The 14-month-old male mice were administered with PBS, FGF21 or metformin once daily for 6 ...
Mongiardi, Maria Patrizia Merolle, Matilde Fustaino, Valentina Levi, Andrea Falchetti, Maria Laura
Published in
Aging clinical and experimental research
Endothelial cells senescence is a physiological process affecting vascular integrity. It can contribute to heart and arterial stiffening and remodeling, impaired angiogenesis, defective vascular repair, and with an increasing prevalence of atherosclerosis. Drugs used as antineoplastic therapies, targeting tumor as well as endothelial cells, can als...
Wojciechowska, Natalia Michalak, Kornel M. Bagniewska-Zadworna, Agnieszka
Published in
Planta
Main ConclusionAutophagy is a key but undervalued process in root ontogeny, ensuring both the proper development of root tissues as well as the senescence of the entire organ.AbstractAutophagy is a process which occurs during plant adaptation to changing environmental conditions as well as during plant ontogeny. Autophagy is also engaged in plant r...
Kychygina, Anna Dall’Osto, Marina Allen, Joshua A. M. Cadoret, Jean-Charles Piras, Vincent Pickett, Hilda A. Crabbe, Laure
Published in
Scientific Reports
Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. A key player in this spatial scattering of chromosomes is the nuclear envelope (NE). The NE tethers large chromatin domains through interaction with the nuclear lamina and other associated proteins. This organizatio...
Prudence, Samuel MM. Newitt†, Jake T. Worsley, Sarah F. Macey, Michael C. Murrell, J. Colin Lehtovirta-Morley, Laura E. Hutchings, Matthew I.
Published in
Environmental Microbiome
BackgroundConventional methods of agricultural pest control and crop fertilisation are unsustainable. To meet growing demand, we must find ecologically responsible means to control disease and promote crop yields. The root-associated microbiome can aid plants with disease suppression, abiotic stress relief, and nutrient bioavailability. The aim of ...
Zhang, Yan Du, Wanying Zhang, Yunxiu Wang, Zongshuai Li, Huawei Xia, Haiyong Fan, Shoujin Kong, Lingan
Published in
Acta Physiologiae Plantarum
Flag leaves have been considered to be the first key organ contributing to higher yields in triticeae crops. Therefore, dynamical changes in physiological metabolisms in flag leaves are important to regulate senescence and provide reserves to the developing grains. In this study, the dynamic changes in contents of metabolites in flag leaves during ...
Yamaguchi, Yuko Zampino, Marta Tanaka, Toshiko Bandinelli, Stefania Osawa, Yusuke Ferrucci, Luigi Semba, Richard D
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Anemia is common in older adults and associated with greater morbidity and mortality. The causes of anemia in older adults have not been completely characterized. Although elevated circulating growth and differentiation factor 15 (GDF-15) has been associated with anemia in older adults, it is not known whether elevated GDF-15 predicts the developme...
