Girard, Nicolas Lhuissier, Eva Aury-Landas, Juliette Cauvard, Olivier Lente, Marion Boittin, Martine Baugé, Catherine Boumédiene, Karim
Published in
Journal of Bone Oncology
Objectives Chondrosarcomas are malignant bone tumors considered as resistant to radiotherapy. To unravel mechanisms of resistance, we compared biological responses of several chondrosarcomas to X-ray irradiations in normoxia and hypoxia. Since hadrontherapy with Carbon-ions gave interesting clinical outcomes, we also investigated this treatment in ...
Dai, Hanhao Chen, Ran Gui, Chang Tao, Tianqi Ge, Yingbin Zhao, Xilian Qin, Ran Yao, Wangxiang Gu, Song Jiang, Yiqiu
...
Published in
Stem Cell Research & Therapy
BackgroundOsteoarthritis (OA) is a major cause of limb dysfunction, and distraction arthroplasty which generates intermittent hydrostatic pressure (IHP) is an effective approach for OA treatment. However, the result was not always satisfactory and the reasons remained unresolved. Because aging is recognized as an important risk factor for OA and ch...
Chen, Yi-Ling Sheu, Jiunn-Jye Sun, Cheuk-Kwan Huang, Tien-Hung Lin, Yuan-Ping Yip, Hon-Kan
Published in
Molecular Medicine
BackgroundMicroRNAs control gene expression by post-transcriptional inhibition. Dysregulation of the expressions of miR-199a/214 cluster has been linked to cardiovascular diseases. This study aimed at identifying potential microRNAs related to vascular senescence.MethodsSeven candidate microRNAs (miR-19a, −20a, −26b, −106b, − 126, − 214, and − 374)...
weili, xu xuan lau, zandrea wan fulop, tamas larbi, anis
In the coming decades, many developed countries in the world are expecting the &ldquo / greying&rdquo / of their populations. This phenomenon poses unprecedented challenges to healthcare systems. Aging is one of the most important risk factors for infections and a myriad of diseases such as cancer, cardiovascular and neurodegenerative diseases. A c...
Goh, Kim Jee Chen, Jian-Hua Rocha, Nuno Semple, Robert K.
Published in
Scientific Reports
Werner Syndrome (WS) and Bloom Syndrome (BS) are disorders of DNA damage repair caused by biallelic disruption of the WRN or BLM DNA helicases respectively. Both are commonly associated with insulin resistant diabetes, usually accompanied by dyslipidemia and fatty liver, as seen in lipodystrophies. In keeping with this, progressive reduction of sub...
Frausto, Ricardo F. Swamy, Vinay S. Peh, Gary S. L. Boere, Payton M. Hanser, E. Maryam Chung, Doug. D. George, Benjamin L. Morselli, Marco Kao, Liyo Azimov, Rustam
...
Published in
Scientific Reports
The advent of cell culture-based methods for the establishment and expansion of human corneal endothelial cells (CEnC) has provided a source of transplantable corneal endothelium, with a significant potential to challenge the one donor-one recipient paradigm. However, concerns over cell identity remain, and a comprehensive characterization of the c...
Bian, Xiaowei Li, Bingmin Yang, Jie Ma, Kui Sun, Mengli Zhang, Cuiping Fu, Xiaobing
Published in
Stem Cell Research & Therapy
BackgroundFibroblasts are crucial for supporting normal wound healing. However, the functional state of these cells is impaired in diabetics because of a high-glucose (HG) microenvironment. Small extracellular vesicles (sEVs) have emerged as a promising tool for skin wound treatment. The aim of this study was to investigate the effects of sEVs deri...
Oliver, Melvin J. Farrant, Jill Margaret Hilhorst, Henk Mundree, Sagadevan Williams, Brett Bewley, Derek
Desiccation of plants is often lethal but is tolerated by the majority of seeds and by vegetative tissues of only a small number of land plants. Desiccation tolerance is an ancient trait, lost from vegetative tissues following the appearance of tracheids but reappearing in several lineages when selection pressures favored its evolution. Cells of al...
Ben Kacem, M. Benadjaoud, M. A. Dos Santos, M. Soysouvanh, F. Buard, V. Tarlet, G. Le Guen, B. François, A. Guipaud, O. Milliat, F.
...
Published in
Scientific Reports
Whereas an RBE > 1 is described for very low-energy X-ray beams (in the range of 25–50 kV), there is a consensus that the RBE of X-rays (from 0.1 to 3 MeV) is equal to 1, whatever the energy or dose rate of the beam. Comparisons of X-ray beam dose rates are scarce even though these beams are widely used in medical diagnosis or radiotherapy. By usin...
Cai, Yusheng Zhou, Huanhuan Zhu, Yinhua Sun, Qi Ji, Yin Xue, Anqi Wang, Yuting Chen, Wenhan Yu, Xiaojie Wang, Longteng
...
Published in
Cell Research
Cellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms, contributes to tissue dysfunction, and drives age-related phenotypes. The clearance of senescent cells is expected to decrease chronic, low-grade inflammation and improve tissue repair capacity, thus attenuating the decline of physical function in aged orga...
