Zhang, Wei Xia, Siyu Xiao, Wei Song, Yali Tang, Li Cao, Min Yang, Jing Wang, Shuang Li, Zhijie Xu, Chengchao
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Published in
Journal of advanced research
Advanced paternal age of reproduction is an increasing trend, especially in developed countries and areas. This trend results in elevated risks of adverse reproductive outcomes such as reduced fertility rates, increased pregnancy loss, and poor childhood health. Yet, a systematic profiling of aging-associated molecular and cellular alterations in t...
Zhou, Dan Jang, Ji Min Yang, Goowon Ha, Hae Chan Fu, Zhicheng Kim, Dae Kyong
Published in
Biomolecules & therapeutics
Cardiovascular diseases (CVDs) are the most common cardiovascular system disorders. Cellular senescence is a key mechanism associated with dysfunction of aged vascular endothelium. Hyaluronic acid and proteoglycan link protein 1 (HAPLN1) has been known to non-covalently link hyaluronic acid (HA) and proteoglycans (PGs), and forms and stabilizes HAP...
Plaza Soriano, Javier
[ES] La enfermedad de Crohn (EC) es una patología inflamatoria multifactorial, crónica y recidivante del tracto gastrointestinal. En un alto porcentaje de pacientes, la enfermedad se asocia con complicaciones como la estenosis o la aparición de fístulas para las que no existe ni prevención ni tratamiento. En muchos casos, estos pacientes requieren ...
Hughes, Bethany K Wallis, Ryan Bishop, Cleo L
Published in
Cell and tissue research
Senescence is a widely appreciated tumour suppressive mechanism, which acts as a barrier to cancer development by arresting cell cycle progression in response to harmful stimuli. However, senescent cell accumulation becomes deleterious in aging and contributes to a wide range of age-related pathologies. Furthermore, senescence has beneficial roles ...
Zhang, Yuhang Peng, Xuyan Xue, Mengjiao Liu, Jingjing Shang, Guohui Jiang, Mingjun Chen, Dandan Liu, Baixue Wang, Yuxuan Jia, Xiaolin
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Published in
Biogerontology
SARS-Cov-2 infection, which has caused the COVID-19 global pandemic, triggers cellular senescence. In this study, we investigate the role of the SARS-COV-2 spike protein (S-protein) in regulating the senescence of RPE cells. The results showed that administration or overexpression of S-protein in ARPE-19 decreased cell proliferation with cell cycle...
Javali, Prashanth S Sekar, Mouliganesh Kumar, Ashish Thirumurugan, Kavitha
Published in
Biogerontology
Review paper attempts to explain the dynamic aspects of redox signaling in aging through autophagy, inflammation, and senescence. It begins with ROS source in the cell, then states redox signaling in autophagy, and regulation of autophagy in aging. Next, we discuss inflammation and redox signaling with various pathways involved: NOX pathway, ROS pr...
Lin, Meng-Juan Hu, Shi-Liang Tian, Ying Zhang, Jing Liang, Na Sun, Rong Gong, Shao-Xin Wang, Ai-Ping
Published in
Journal of cardiovascular translational research
Vascular diseases are a major threat to human health, characterized by high rates of morbidity, mortality, and disability. VSMC senescence contributes to dramatic changes in vascular morphology, structure, and function. A growing number of studies suggest that VSMC senescence is an important pathophysiological mechanism for the development of vascu...
Xiang, Xiuting Xie, LiangZhen Lin, Jieqi Pare, Rahmawati Huang, Guanshen Huang, Jianming Wang, Yuyan Song, Shicong Ruan, Yunjun
Published in
Biogerontology
Atherosclerosis threatens human health by developing cardiovascular diseases, the deadliest disease world widely. The major mechanism contributing to the formation of atherosclerosis is mainly due to vascular endothelial cell (VECs) senescence. We have shown that 17β-estradiol (17β-E2) may protect VECs from senescence by upregulating autophagy. How...
Hannan, Raquibul McLaughlin, Mark F Pop, Laurentiu M Pedrosa, Ivan Kapur, Payal Garant, Aurelie Ahn, Chul Christie, Alana Zhu, James Wang, Tao
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Published in
European urology
Most renal cell carcinomas (RCCs) are localized and managed by active surveillance, surgery, or minimally invasive techniques. Stereotactic ablative radiation (SAbR) may provide an innovative non-invasive alternative although prospective data are limited. To investigate whether SAbR is effective in the management of primary RCCs. Patients with biop...
Huang, Xiaoran Liu, Baojuan Liang, Yaowen Mai, Cong Shen, Ying Huang, Xinran Chen, Jiaqi Liang, Xiaoting Hu, Bei Li, Weifeng
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Published in
Heliyon
The cellular senescence of mesenchymal stem cells (MSCs) limits their application in regenerative medicine. This study aimed to clarify the role of TNF receptor-associated factor 3 interacting protein 2 (TRAF3IP2), a pro-inflammatory cytoplasmic adaptor protein, in regulating MSC senescence and to explore the potential mechanisms. Methods: MSC sene...