Nangia, Aayushi Saravanan, Janani Srividya Hazra, Shruti Priya, Vijayan Sudesh, Ravi Rana, Sandeep Singh Ahmad, Faraz
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Diabetes mellitus (DM) and epilepsy and the psychological and socio-economic implications that are associated with their treatments can be quite perplexing. Metformin is an antihyperglycemic medication that is used to treat type 2 DM. In addition, metformin elicits protective actions against multiple diseases, including neurodegeneration and epilep...
Pastor-Alonso, Oier Durá, Irene Bernardo-Castro, Sara Varea, Emilio Muro-García, Teresa Martín-Suárez, Soraya Encinas-Pérez, Juan Pineda, Jose
Hippocampal seizures mimicking mesial temporal lobe epilepsy cause a profound disruption of the adult neurogenic niche in mice. Seizures provoke neural stem cells to switch to a reactive phenotype (reactive neural stem cells, React-NSCs) characterized by multibranched hypertrophic morphology, massive activation to enter mitosis, symmetric division,...
Wong, Kingsley Junaid, Mohammed Alexander, Solomon Olson, Heather Pestana-Knight, Elia Rajaraman, Rajsekar Downs, Jenny Leonard, Helen
BACKGROUND AND OBJECTIVE: CDKL5 deficiency disorder presents as a challenging condition with early-onset refractory seizures, severe developmental delays, and a range of other neurological symptoms. Our study aimed to explore the benefits and side effects of anti-seizure medications (ASMs) in managing seizures among individuals with CDKL5 deficienc...
Moreau-Kastler, N. Toubal, Farid
We show that legal opacity is a strong factor in drug trafficking. We develop a new framework that illustrates how legal opacity influences countries’ seizure rates.Legal opacity reduces the detection of illicit flows and increases their volumes because it lowers trafficking costs. We use detailed information from financial systems evaluations, int...
Mohammadi, Nazanin Azarinejad Ahring, Philip Kiær Yu Liao, Vivian Wan Chua, Han Chow Ortiz de la Rosa, Sebastián Johannesen, Katrine Marie Michaeli-Yossef, Yael Vincent-Devulder, Aline Meridda, Catherine Bruel, Ange-Line
...
International audience
Zabler, Nicolas; Swinnen, Lauren; 129513; Biondi, Andrea; Novitskaya, Yulia; Schuetz, Elisa; Epitashvili, Nino; Duempelmann, Matthias; Richardson, Mark P.; Van Paesschen, Wim; 15539; Schulze-Bonhage, Andreas;
...
People with epilepsy frequently under- or inaccurately report their seizures, which poses a challenge for evaluating their treatment. The introduction of epilepsy health apps provides a novel approach that could improve seizure documentation. This study assessed the documentation performance of an app-based seizure diary and a conventional paper se...
Downs, J Jacoby, P Specchio, N Cross, H Amin, S Bahi-Buisson, N Rajaraman, Rajsekar Suter, B Devinsky, O Aimetti, A
...
CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy. Ganaxolone, a neuroactive steroid, reduces the frequency of major motor seizures in children with CDD. This analysis explored the effect of ganaxolone on non-seizure outcomes. Children (2-19 years) with genetically confirmed CDD and ≥ 16 major motor seizures per m...
Emam, Bayoumi A. Abdel-Hamid, Mohamed S. Eid, Maha Girgis, Marian Ragab, Omar A. Zaki, Maha S. El-Kiki, Hassan Abdel-Hady, Sawsan Abdel-Salam, Ghada M.H.
Published in
Molecular Syndromology
Introduction: Pontocerebellar hypoplasia (PCH) represents a group of rare disorders with prenatal onset and time-dependent loss of brain parenchyma, predominantly affecting the cerebellum and pons with variable involvement of supratentorial structures. Radiologically and pathologically, they are characterized by small cerebellum and pons. Our study...
Sahraoui, Houssam Eddine Danaoui, Kaoutar Sihami, Abdelaziz Mouaffak, Youssef Younous, Said
Published in
Open Access Macedonian Journal of Medical Sciences
BACKGROUND Febrile infection-related epilepsy syndrome (FIRES) is a subset of NORSE that requires a febrile infection between 24 h and 2 weeks before the onset of refractory status epilepticus (SE), with or without fever at the onset of SE, and with no restriction to the age of the patient. The literature on FIRES is scarce. CASE PRESENTATION This ...
Stieren, Emily S Rottkamp, Catherine A Brooks-Kayal, Amy R
Neonatal seizures are common among patients with acute brain injury or critical illness and can be difficult to diagnose and treat. The most common etiology of neonatal seizures is hypoxic-ischemic encephalopathy, with other common causes including ischemic stroke and intracranial hemorrhage. Neonatal clinicians can use a standardized approach to p...
