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A Cytotoxic Principle of Tamarindus indica, Di-w-butyl Malate and the Structure-Activity Relationship of Its Analogues

Published in Zeitschrift für Naturforschung C

Bioassay-guided fractionation of the methanolic extract of Tamarindus indica fruits led to the isolation of L -(-)-di-nbutyl malate which exhibited a pronounced cytotoxic activity against sea urchin embryo cells. In order to study structure-activity relationships, close-structure relatives of di-n-butyl malate were synthesized using d -(+) -and L -...