Mallet, Romain Modzelewski, Romain Lequesne, Justine Mihailescu, Sorina Decazes, Pierre Auvray, Hugues Benyoucef, Ahmed Di Fiore, Fréderic Vera, Pierre Dubray, Bernard
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Published in
Radiation Oncology
BackgroundSarcopenia is defined by a loss of skeletal muscle mass with or without loss of fat mass. Sarcopenia has been associated to reduced tolerance to treatment and worse prognosis in cancer patients, including patients undergoing surgery for limited oesophageal cancer. Concomitant chemo-radiotherapy is the standard treatment for locally-advanc...
Go, Se-Il Kim, Hoon-Gu Kang, Myoung Hee Park, Sungwoo Lee, Gyeong-Won
Published in
BMC Cancer
BackgroundSystemic inflammation and cachexia are associated with adverse clinical outcomes in diffuse large B-cell lymphoma (DLBCL). The Geriatric Nutritional Risk Index (GNRI) is one of the main parameters used to assess these conditions, but its efficacy in DLBCL is inconclusive.MethodsWe retrospectively reviewed 228 DLBCL patients who were treat...
Pickering, Marie-Eva Chapurlat, Roland
Published in
Calcified tissue international
Osteoarthritis and sarcopenia are the most frequently described musculoskeletal disorders in older persons but the intertwining of these conditions and of their functional and cellular causes is complex. This narrative review aims to identify the links between osteoarthritis and sarcopenia described 1-in clinical studies, 2-in in vitro studies, and...
Koshikawa, Masayuki Harada, Masahide Noyama, Shunsuke Kiyono, Ken Motoike, Yuji Nomura, Yoshihiro Nishimura, Asuka Izawa, Hideo Watanabe, Eiichi Ozaki, Yukio
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Published in
BMC Cardiovascular Disorders
BackgroundInflammation and skeletal muscle wasting often coexist in elderly populations, but few studies have examined their relationship in elderly heart failure (HF) patients. This study examined the relationship between inflammation and increased skeletal muscle proteolysis, reduced skeletal mass and strength, and their prognostic implications i...
Jain, Rishi Coss, Chris Whooley, Peter Phelps, Mitch Owen, Dwight H.
Published in
Current Oncology Reports
Purpose of ReviewMalnutrition, cancer cachexia, and sarcopenia often co-occur in patients with advanced cancer and are associated with poorer response to chemotherapy and reduced survival. Here, we evaluate the current literature regarding the role of nutrition and these associated conditions in patients with advanced lung cancer.Recent FindingsWhi...
Lasman, N. Shalom, M. Turpashvili, N. Goldhaber, G. Lifshitz, Y. Leibowitz, E. Berger, G. Saltzman-Shenhav, G. Brom, A. Cohen, D.
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Published in
BMC Pulmonary Medicine
BackgroundCOPD exacerbations have negative impact on patients’ survival. Several risk factors for grave outcomes of such exacerbations have been descried. Muscle dysfunction and mass loss were shown to impact negatively on prognosis and survival. Low activity of the enzyme ALT (Alanine amino-transferase) in the blood is a known indicator for sarcop...
Yasuda, Megumi Iizuka, Katsumi Kato, Takehiro Liu, Yanyan Takao, Ken Nonomura, Kenta Mizuno, Masami Yabe, Daisuke
Published in
Journal of diabetes investigation
A 70-year-old woman with type 2 diabetes was admitted to Gifu University Hospital, Gifu, Japan, because of ketosis. She was diagnosed with type 2 diabetes at age 49 years and started insulin therapy at age 57 years, which restored glycemic control. Insulin therapy was discontinued and oral antidiabetes drugs, including sodium-glucose cotransporter ...
Zambrano, Daniela N Xiao, Jingjie Prado, Carla M Gonzalez, M Cristina
Published in
Clinical nutrition (Edinburgh, Scotland)
Chronic liver disease often occurs with malnutrition and its primary consequences, loss of strength and muscle mass (sarcopenia) have an impact on worsening quality of life and increased mortality. The objective of this study was to investigate the usefulness of computed tomography (CT) and Patient-Generated Subjective Global Assessment (PG-SGA) in...
Randolph, Amanda C Markofski, Melissa M Rasmussen, Blake B Volpi, Elena
Published in
Clinical nutrition (Edinburgh, Scotland)
The combination of prolonged essential amino acid (EAA) supplementation and aerobic exercise training (Ex) improves muscle protein metabolism, strength and function in healthy older adults. However, excess EAA intake may worsen insulin sensitivity. Here we report the effects of EAA supplementation (EAA, n = 11), placebo (PLA, n = 10), aerobic exerc...
Tabara, Yasuharu Ikezoe, Tome Setoh, Kazuya Sugimoto, Ken Kawaguchi, Takahisa Kosugi, Shinji Nakayama, Takeo Ichihashi, Noriaki Tsuboyama, Tadao Matsuda, Fumihiko
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Published in
Archives of gerontology and geriatrics
Sarcopenia in older adults is a risk factor for age-related morbidity and mortality. This study aimed to clarify the diagnostic significance of the revised diagnostic algorithm for sarcopenia from Asian Working Group for Sarcopenia by comparing physical and clinical characteristics of individuals diagnosed with sarcopenia by the initial and revised...
