Chisari, Clara Grazia Sgarlata, Eleonora Arena, Sebastiano Toscano, Simona Luca, Maria Patti, Francesco
Published in
Journal of neurology
In the last decades, evidence suggesting the direct or indirect involvement of B cells on multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on the efficacy and safety of B-cell-depleting therapies from several studies has suggested the addition of these drugs as treatment options to the current armamentarium of dise...
Memarian, Parastoo Sartor, Francesco Bernardo, Enrico Elsayed, Hamada Ercan, Batur Delogu, Lucia Gemma Zavan, Barbara Isola, Maurizio
Published in
International journal of molecular sciences
Carbon enriched bioceramic (C-Bio) scaffolds have recently shown exceptional results in terms of their biological and mechanical properties. The present study aims at assessing the ability of the C-Bio scaffolds to affect the commitment of canine adipose-derived mesenchymal stem cells (cAD-MSCs) and investigating the influence of carbon on cell pro...
Toor, Kabirraaj Middleton, Mark R. Chan, Keith Amadi, Adenike Moshyk, Andriy Kotapati, Srividya
Published in
BMC Cancer
BackgroundImmune checkpoint inhibitors and targeted therapies are approved for adjuvant treatment of patients with resected melanoma; however, they have not been compared in randomized controlled trials (RCTs). We compared the efficacy and safety of adjuvant nivolumab with other approved treatments using available evidence from RCTs in a Bayesian n...
Li, Dongxu Zhou, Xu An, Qi Feng, Yuan
Published in
Heart failure reviews
We aimed to assess the efficacy and safety of pulmonary vasodilators in patients after the Fontan procedure. The PubMed, EMBASE, and Cochrane Library databases were searched through November 2019 for studies comparing pulmonary vasodilators and controls in Fontan patients. The variables assessed included change in pulmonary resistance, heart functi...
Rugo, Hope S Huober, Jens García-Sáenz, José A Masuda, Norikazu Sohn, Joo Hyuk Andre, Valerie A M Barriga, Susana Cox, Joanne Goetz, Matthew
Published in
The oncologist
Abemaciclib demonstrated efficacy in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer. Here we provide a comprehensive summary of the most common adverse events (AEs), their management, and whether AEs or dose reductions influenced progression-free survival (PFS), in the MONARCH 2 and 3 trials. Inc...
Knobel, Pablo Maneja, Roser Bartoll, Xavier Alonso, Lucia Bauwelinck, Mariska Valentin, Antonia Zijlema, Wilma Borrell, Carme Nieuwenhuijsen, Mark Dadvand, Payam
...
Published in
Environmental pollution (Barking, Essex : 1987)
The quality characteristics of urban green spaces (UGS) have been suggested to play a critical role in their use and their potentials to exert health effects. However, epidemiological studies evaluating such a role are scarce. These studies have generally focused on a limited number of quality dimensions. We studied the association between 10 UGS q...
Liu, Chang Dong, Wenliang Xia, Lin Lv, Jie Jiang, Daoli Wang, Qian Wang, Mei Wu, Maofeng Miao, Jingwei Tao, Tao
...
Published in
International immunopharmacology
SSS07, a humanized rabbit monoclonal antibody, can selectively block human tumor necrosis factor-α (TNF-α). The objective of this study was to assess the safety, tolerability, and relative immunogenicity of SSS07 after multiple single subcutaneous (SC) doses in healthy volunteers. A total of 71 healthy volunteers were randomized to six sequential a...
Nielsen, Morten Birkeland Christensen, Jan Olav Emberland, Jan Shahid Skogstad, Marit Knardahl, Stein Finne, Live Bakke
Published in
Waste management (New York, N.Y.)
A valid, standardized tool for assessing workplace safety can help organizations and employers to detect potential safety risks. This is crucial to improve safety and protect employees and production against accidents and injuries. As no such tool has so far been developed for the waste management industry, this study aimed to establish the psychom...
Tan, Y. N. Vandekerckhove, PJ. Verdonk, P
Published in
Journal of Experimental Orthopaedics
PurposeThe primary aim of our study was to investigate elective orthopaedic care during the first wave government-imposed COVID-19 lockdown and at four weeks and 21 weeks after resuming elective care. The secondary aim of our study was to evaluate the implementation of the European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA...
Gurrera, Ronald J
Published in
Psychiatry research
Clozapine is vastly underutilized in the United States and many other countries. The most commonly cited reason for this is the requirement for frequent blood monitoring, which continues for the duration of treatment. Despite the notoriety clozapine achieved early in its development, accumulated evidence has demonstrated that close blood monitoring...