PURPOSE: Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant mortality. We investigated whether antifungal prophylaxis reduces the incidence of IAPA. METHODS: We compared 7 days of intravenous posaconazole (POS) prophylaxis with no prophylaxis (standard-of-...
Rationale: Estimating the impact of ventilator-associated pneumonia (VAP) from routinely collected ICU data is methodologically challenging. Objectives: We aim to replicate earlier findings of limited VAP-attributable ICU mortality in an independent cohort. By refining statistical analyses, we gradually tackle different sources of bias. Methods: Re...
Background General practitioners (GPs) play a key role in managing the COVID-19 outbreak. However, they may encounter difficulties adapting their practices to the pandemic. We provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the pandemic from 15 countries. Methods A network of GPs collaborated to...
Vibrio parahaemolyticus is becoming the leading cause of acute bacterial gastroenteritis, but its population dynamics in aquafarms have received limited attention. To address this research gap, we selected three shellfish farms to examine the impacts of ocean currents and the transport of live aquatic animals on the transmission and microevolution ...
For lifeguards, recognizing a swimmer in trouble is a key factor in the rescue process. Although reports show that lifeguards outperform non-lifeguards in their surveillance task, it is unclear to what extent this difference is reflected in gaze behaviour. In the current study, gaze behaviour of nine novice and seven experienced beach lifeguards wa...
Reconnues comme une cause majeure de destruction des récifs coralliens de l'Indo-Pacifique, ces proliférations ont fait l'objet d'un important effort de recherche scientifique mais ont également entraîné la mise en oeuvre d'ambitieux programmes de gestion dans certains pays de la région. En Nouvelle-Calédonie, plusieurs événements de proliférations...
Published in European journal of human genetics : EJHG
Fifty years after the recognition of the Li-Fraumeni syndrome (LFS), our perception of cancers related to germline alterations of TP53 has drastically changed: (i) germline TP53 alterations are often identified among children with cancers, in particular soft-tissue sarcomas, adrenocortical carcinomas, central nervous system tumours, or among adult ...
Yellow fever (YF) causes high fever, liver dysfunction, renal failure, hypercoagulopathy and platelet dysfunction and can lead to shock and death with a case-fatality ratio of 20-50%. YF vaccination results in long-lasting protective immunity. Serious adverse events (SAEs), such as YF vaccine-associated neurotropic disease (YEL-AND) are rare. We pr...
OBJECTIVES: The protracted and violent conflict in Syria has resulted in large-scale displacement of people and destruction of health and sanitation infrastructure. The aim of this study was to examine epidemiological trends in vector-borne disease (VBD) outbreaks before and following the onset of the Syrian conflict (2011). METHODS: ProMED, a digi...
Published in European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Unilateral spastic cerebral palsy (USCP) occurs in 30%-68% of infants with perinatal stroke. Early detection of USCP is essential for referring infants to early intervention. The aims of this study were to report motor outcomes after perinatal stroke, and to determine the predictive value of the General Movements Assessment (GMA) and Hand Assessmen...
