grotto, andrea casas, i pau fonseca zubaryeva, alyona sparber, wolfram
Background: Urban mobility management faces growing challenges that require the analysis and optimization of sustainable solutions. Digital twins (DTs) have emerged as innovative tools for this assessment, but their implementation requires standardized procedures and languages; Methods: As part of a broader methodology for continuous DT validation,...
Claessens, Laura A Vertegaal, Alfred C O
Published in
Trends in cell biology
Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in regulating diverse cellular processes including gene expression, cell cycle progression, genome integrity, cellular metabolism, and inflammation and immunity. The covalent attachment of SUMOs to target proteins is highly dynamic and reversible through the concer...
paubel, agathe marouillat, sylviane dangoumau, audrey maurel, cindy haouari, shanez blasco, hélène corcia, philippe laumonnier, frédéric andres, christian r. vourc’h, patrick
...
Background: The ubiquitination process plays a crucial role in neuronal differentiation and function. Numerous studies have focused on the expression and functions of E3 ligases during these different stages, far fewer on E2 conjugating enzymes. In mice, as in humans, these E2s belong to 17 conjugating enzyme families. Objectives: We analyzed by re...
kolbe, niklas berghaus, moritz kalló, eszter herty, michael oeser, markus
While macroscopic traffic flow models adopt a fluid dynamic description of traffic, microscopic traffic flow models describe the dynamics of individual vehicles. Capturing macroscopic traffic phenomena accurately remains a challenge for microscopic models, especially in complex road sections. Based on a macroscopic network flow model calibrated to ...
Chah, Badreddine Lombard, Alexandre Mualla, Yazan Bkakria, Anis Abbas-Turki, Abdeljalil Yaich, Reda
Classifying the driving styles is of particular interest for enhancing road safety in smart cities. The vehicle can assist the driver by providing advice to increase awareness of potential dangers. Accordingly, dissuasive measures, such as adjusting insurance costs, can be implemented. The service is called Pay-As-You-Drive insurance (PAYD), and to...
Saleem, Yasir Mitton, Nathalie Loscri, Valeria
The protocols for vehicular networks are mostly developed, tested and evaluated through simulations in network simulators first before implementing and experimenting them in the real-world. For simulating vehicular networks, various mobility datasets are made publicly available by SUMO that can be imported into network simulators (e.g., OMNeT++, NS...
zahwa, firas cheng, chi-tsun simic, milan
Efficient traffic flow management at intersections is vital for optimizing urban transportation networks. This paper presents a comprehensive approach to refining traffic flow by analyzing the capacity of roads and integrating fuzzy logic-based traffic light control systems. We examined the capacity of roads connecting intersections, considering fa...
orsini, franca bosica, marco martucci, annacarla de paola, massimiliano comolli, davide pascente, rosaria forloni, gianluigi fraser, paul e. arancio, ottavio fioriti, luana
...
Neurologic manifestations are an immediate consequence of SARS-CoV-2 infection, the etiologic agent of COVID-19, which, however, may also trigger long-term neurological effects. Notably, COVID-19 patients with neurological symptoms show elevated levels of biomarkers associated with brain injury, including Tau proteins linked to Alzheimer’s patholog...
Day, Jennifer L. Tirard, Marilyn Brose, Nils
Published in
Frontiers in Molecular Neuroscience
Introduction The Anaphase Promoting Complex (APC/C), an E3 ubiquitin ligase, plays a key role in cell cycle control, but it is also thought to operate in postmitotic neurons. Most studies linking APC/C function to neuron biology employed perturbations of the APC/C activators, cell division cycle protein 20 (Cdc20) and Cdc20 homologue 1 (Cdh1). Howe...
ouyang, chen zhan, zhenfei fengyao, lv
In recent years, the increasing production and sales of automobiles have led to a notable rise in congestion on urban road traffic systems, particularly at ramps and intersections with traffic signals. Intelligent traffic signal control represents an effective means of addressing traffic congestion. Reinforcement learning methods have demonstrated ...
