Some observations on the influence of particle size and size distribution on stratification in pneumatic jigs
Model for end-stage liver disease score and hemodynamic instability as a predictor of poor outcome in early transjugular...
Genomic amplifications and distal 6q loss : novel markers for poor survival in high-risk neuroblastoma patients
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Background: Neuroblastoma is characterized by substantial clinical heterogeneity. Despite intensive treatment, the survival rates of high-risk neuroblastoma patients are still disappointingly low. Somatic chromosomal copy number aberrations have been shown to be associated with patient outcome, particularly in low-and intermediate-risk neuroblastom...
Diagnosis of cardiac surgery-associated acute kidney injury : differential roles of creatinine, chitinase 3-like protein...
Background: A common and serious complication of cardiac surgery prompting early detection and intervention is cardiac surgery-associated acute kidney injury (CSA-AKI). Urinary chitinase 3-like protein 1 (UCHI3L1) was found to predict AKI associated with critical illness in adults. Our aims were therefore to evaluate whether UCHI3L1 can also be use...
Epigenetic risk score improves prostate cancer risk assessment
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Background: Early detection of aggressive prostate cancer (PCa) remains crucial for effective treatment of patients. However, PCa screening remains controversial due to a high rate of overdiagnosis and overtreatment. To better reconcile both objectives, more effective methods for assessing disease severity at the time of diagnosis are needed. Metho...
Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastom...
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Background: High-dose chemotherapy with haemopoietic stem-cell rescue improves event-free survival in patients with high-risk neuroblastoma; however, which regimen has the greatest patient benefit has not been established. We aimed to assess event-free survival after high-dose chemotherapy with busulfan and melphalan compared with carboplatin, etop...
Stage 4S neuroblastoma tumors show a characteristic DNA methylation portrait
Stage 4S neuroblastoma (NB) is a special type of NB found in infants with metastases at diagnosis and is associated with an excellent outcome due to its remarkable capacity to undergo spontaneous regression. As genomics have not been able to explain this intriguing clinical presentation, we here aimed at profiling the DNA methylome of stage 4S NB t...
Lower-track students’ sense of academic futility: Selection or effect?
Given the importance of students’ judgement of the future rewarding character of studying for their willingness to deliver effort at school, we propose the concept of sense of academic futility to understand track differences in achievement. As research is inconclusive in this matter, this study examines whether negative attitudes such as sense of ...
Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
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Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total, 396 low- and high-risk primary tumors were analyzed, of which 87 were profiled using methyl-CpG-binding domain (MBD) sequencing for differential methylation analysis bet...
Synoptic-scale analysis of mechanisms driving surface chlorophyll dynamics in the North Atlantic
Several hypotheses have been proposed for the onset of the spring phytoplankton bloom in the North Atlantic. Our main objective is to examine which bottom-up processes can best predict the annual increase in surface phytoplankton concentration in the North Atlantic by applying novel phenology algorithms to ocean colour data. We construct indicator ...
