In-situ synchrotron computed tomography tensile testing of composite specimens to estimate fibre strength Weibull parame...
status: published
Generalized pairwise comparisons for censored data: An overview
The method of generalized pairwise comparisons (GPC) is an extension of the well-known nonparametric Wilcoxon-Mann-Whitney test for comparing two groups of observations. Multiple generalizations of Wilcoxon-Mann-Whitney test and other GPC methods have been proposed over the years to handle censored data. These methods apply different approaches to ...
Heterogeneous causal effects with imperfect compliance: a Bayesian machine learning approach
This paper introduces an innovative Bayesian machine learning algorithm to draw interpretable inference on heterogeneous causal e ects in the presence of imperfect compliance (e.g., under an irregular assignment mechanism). We show, through Monte Carlo simulations, that the proposed Bayesian Causal Forest with Instrumental Variable (BCF-IV) methodo...
An efficient algorithm to assess multivariate surrogate endpoints in a causal inference framework
status: published
Stroke genetics informs drug discovery and risk prediction across ancestries
...
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify associ...
Comorbidity patterns, family history and breast cancer risk: a latent class analysis.
...Published in Journal of epidemiology and community health
Limited evidence exists on how the presence of multiple conditions affects breast cancer (BC) risk. We used data from a network hospital-based case-control study conducted in Italy and Switzerland, including 3034 BC cases and 3392 controls. Comorbidity patterns were identified using latent class analysis on a set of specific health conditions/disea...
Analysis of Exosomal Cargo Provides Accurate Clinical, Histologic and Mutational Information in Non-Small Cell Lung Canc...
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Lung cancer is a malignant disease with high mortality and poor prognosis, frequently diagnosed at advanced stages. Nowadays, immense progress in treatment has been achieved. However, the present scenario continues to be critical, and a full comprehension of tumor progression mechanisms is required, with exosomes being potentially relevant players....
Le Nombre des hommes. La mesure de la population et ses enjeux (XVIe-XXIe siècle)
En quoi chiffrer les groupes humains est-il nécessaire ? S’agit-il d’une activité sans danger ? Cet essai propose une histoire du « nombre de la population » depuis le XVIe siècle qui mêle l’histoire des savoirs, l’histoire des doctrines et l’histoire des politiques de population.
Classifying Individuals by Their Participation in the Production System: The ‘Active’ and ‘Inactive’ Populations in Late...
The partition of the French population into ‘active’ and ‘inactive’ subpopulations, a 19th-century construction, emerged out of interactions between two conceptions of activity. The first, introduced in the early 1860s, aimed to construct social classes based on the position of the household head, representing society through its structuring depend...
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
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Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are exp...
