BACKGROUND: Inflammation and one of its mediators, NF-kappa B (NFκB), have been implicated in prostate cancer carcinogenesis. We assessed whether germline polymorphisms associated with NFκB are associated with the risk of developing lethal disease (metastases or death from prostate cancer). METHODS: Using a Bayesian approach leveraging NFκB biology...
Background: Histological subtypes of colorectal cancer may be associated with varied prognostic features. This systematic review and meta-analysis aimed to compare clinicopathological characteristics, recurrence and overall survival between colorectal signet-ring cell (SC) and mucinous carcinoma (MC) to conventional adenocarcinoma (AC). Methods: A ...
Un tutoriel est mis à disposition pour l’application du logiciel R des méthodes présentées dans l’ouvrage. Il est intégré dans la vignette du package « seqhandbook », consultable sur la plateforme Nakala en français et en anglais.
How many colors are there? Quoted numbers range from ten million to a dozen. Are colors object properties? Opinions range all the way from of course they are to no, colors are just mental paint. These questions are ill-posed. We submit that the way to tackle such questions is to adopt a biological approach, based on the evolutionary past of hominin...
Published in Journal of epidemiology and community health
Attrition, the loss of participants as a study progresses, is a considerable challenge in longitudinal studies. This study examined whether two forms of attrition, 'withdrawal' (formal discontinued participation) and 'non-response' (non-response among participants continuing in the study), have different associations with mortality and whether thes...
Published in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
We tested the hypothesis that static stretching, an acute, nonmetabolic fatiguing intervention, reduces exercise tolerance by increasing muscle activation and affecting muscle bioenergetics during cycling in the "severe" intensity domain. Ten active men (age, 24 ± 2 years; body mass, 74 ± 11 kg; height, 176 ± 8 cm) participated in identical constan...
Published in Genetic epidemiology
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and s...
Published in Orphanet Journal of Rare Diseases
BackgroundMowat–Wilson syndrome (MWS; OMIM #235730) is a genetic condition caused by heterozygous mutations or deletions of the ZEB2 gene. It is characterized by moderate-severe intellectual disability, epilepsy, Hirschsprung disease and multiple organ malformations of which congenital heart defects and urogenital anomalies are the most frequent on...
Le Comité pour l’élimination de la discrimination raciale (CERD) a été mis en place dans le cadre de la Convention internationale éponyme, adoptée en 1965 et aujourd’hui ratifiée par 182 États. Au cours de ses cinquante années d’existence, ses méthodes de travail ont évolué. Dans un souci de documenter la discrimination de fait (et non seulement de...
