Attrition, the loss of participants as a study progresses, is a considerable challenge in longitudinal studies. This study examined whether two forms of attrition, 'withdrawal' (formal discontinued participation) and 'non-response' (non-response among participants continuing in the study), have different associations with mortality and whether thes...
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and s...
BackgroundMowat–Wilson syndrome (MWS; OMIM #235730) is a genetic condition caused by heterozygous mutations or deletions of the ZEB2 gene. It is characterized by moderate-severe intellectual disability, epilepsy, Hirschsprung disease and multiple organ malformations of which congenital heart defects and urogenital anomalies are the most frequent on...
Le Comité pour l’élimination de la discrimination raciale (CERD) a été mis en place dans le cadre de la Convention internationale éponyme, adoptée en 1965 et aujourd’hui ratifiée par 182 États. Au cours de ses cinquante années d’existence, ses méthodes de travail ont évolué. Dans un souci de documenter la discrimination de fait (et non seulement de...
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and s...
This paper investigates the role of dynamic stress concentrations, and of fracture mechanics-driven growth of critical clusters of fibres, on the longitudinal tensile failure of fibre-reinforced composites. For this purpose, we developed a semi-analytical fibre bundle model to simulate the longitudinal tensile failure of large composite bundles of ...
