Mao, Hongli Sheng, Jinxiu Jia, Jinlin Wang, Chang Zhang, Shanfeng Li, Hongle He, Fucheng
Published in
OncoTargets and therapy
Background Solute carrier family 6 member 14 (SLC6A14) is a high-capacity amino acid transporter in mammalian cells. It has gained increasing attention for its potential involvement in the progression and metabolic reprogramming of various malignant tumors. However, the role of SLC6A14 in colorectal cancer (CRC) remains unclear. Methods Real-time p...
Fu, Yufei Zhu, Fanfan Ma, Zhongjun Lv, Bin Wang, Xi Dai, Chunyan Ma, Xiaoqiong Liu, Pei Lv, Hang Chen, Xin
...
Published in
OncoTargets and therapy
Background Physalis alkekengi var. franchetii is an herb that possesses various ethnopharmacological applications. Herein, our current study focuses on the antitumor effect of a combination of physalins, which are regarded as the most representative secondary metabolites from calyces of Physalis alkekengi var. franchetii . Materials and Methods We ...
Davari, Nader Ahmadpour, Fatemeh Kiani, Ali Asghar Azadpour, Mozhgan Asadi, Zari Tahannejad
Published in
BMC Research Notes
ObjectiveIn chronic lymphocytic leukemia (CLL), lack of expression or dysregulation of some special miRs disrupts apoptosis of malignant cells; thereby miR expression can enhance cell proliferation, disease progression and decrease patient survival.Results30 CLL patients and 20 healthy individuals participated in the study. RNA was extracted to eva...
Zhou, Yunying Chen, Jason J.
Published in
Cell & Bioscience
BackgroundSignal transducers and activators of transcription 3 (STAT3) is a transcription factor that plays a key role in many cellular processes such as cell growth and cancer. However, the functions and mechanisms by which STAT3 regulates cellular processes are not fully understood.ResultsHere we describe a novel function of STAT3. We demonstrate...
Li, Hui Bi, Qianyu Cui, Hongxia Lv, Chuanfeng Wang, Meng
Published in
BMC Complementary Medicine and Therapies
BackgroundAsthma is a chronic inflammatory disease characterized by airway remodeling and inflammation. Rhynchophylline is a kind of indole alkaloid isolated from Uncaria rhynchophylla. Here we investigated the effect of rhynchophylline on autophagy in asthma.MethodsA mice model of asthma was established by ovalbumin challenge. Histopathological ch...
Ou-Yang, Huan Wu, Shinn-Chih Sung, Li-Ying Yang, Shiao-Hsuan Yang, Shang-Hsun Chong, Kowit-Yu Chen, Chuan-Mu
Published in
International Journal of Molecular Sciences
The maternal-to-zygotic transition (MZT), which controls maternal signaling to synthesize zygotic gene products, promotes the preimplantation development of mouse zygotes to the two-cell stage. Our previous study reported that mouse granzyme g (Gzmg), a serine-type protease, is required for the MZT. In this study, we further identified the maternal...
Fang, Ying-Ying Zhang, Jing-Hui
Published in
The International journal of neuroscience
Background: Ischemic stroke is a complex pathological process, involving inflammatory reaction, energy metabolism disorder, free radical injury, cell apoptosis and other aspects. Accumulating evidences have revealed that MFG-E8 had a protective effect on multiple organ injuries. However, the comprehensive function and mechanism of MFG-E8 in ischemi...
Huo, Jing Liu, Taibin Li, Fenghua Song, Xinfeng Hou, Xiuli
Published in
Molecular medicine reports
Vitiligo (VIT) is caused by loss and degradation of functional epidermal melanocytes. Studies have indicated that melanocyte destruction may be associated with an imbalance between regulatory T cells (Treg cells) and effector T cells (Teff cells). The current study aimed to investigate the molecular mechanism through which Treg/Teff balance affects...
Chen, Lirong Yi, Chenhe Li, Wenshuai Tseng, Yujen Zhang, Jun Liu, Jie
Published in
Journal of Cancer
Hepatocellular carcinoma (HCC) is a major global health burden and its treatment options are limited. Spermatogenesis associated serine rich 2(SPATS2), a recent defined oncogene, was found to be a prognostic biomarker in HCC. However, the explicit mechanism underlying SPATS2 was urged to be elucidated. In vitro, knockdown of SPATS2 hampered the pro...
Li, Hui Zhang, Hui-Min Fan, Li-Juan Li, Han-Han Peng, Zi-Tan Li, Jia-Peng Zhang, Xiao-Yu Xiang, Yuan Gu, Chao-Jiang Liao, Xing-Hua
...
Published in
International Journal of Medical Sciences
Endothelial cell proliferation disorder caused by vascular injury seems to be one of the causes of atherosclerosis, which is the pathological basis of coronary heart disease. The role of STAT3 in the regulation of microRNAs and endothelial dysfunction in atherosclerosis is unclear. STAT3 can be activated by cytokine IL-6 and up regulate the express...
