Published in Clinical Immunology (Orlando, Fla.)
• In December 2019, a novel coronavirus of SARS-CoV-2hit Wuhan, Hubei, China, and then spread globally. • SARS-CoV-2 generally causes a mild lower respiratory infection in humans, however, in some severe cases, multiple organ dysfunction occurs. • Overproduction of cytokines, termed cytokine storm, may involve in disease progression and even be res...
Published in Acta pharmaceutica Sinica. B
Coronaviruses (CoVs), a family of enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, unusually large RNA genome, and unique replication capability. CoVs are known to cause various potentially lethal human respiratory infectious diseases, such as severe acute respiratory syndrome (SARS), Midd...
Published in JACC. Basic to translational science
With the complexities that surround myocardial ischemia/reperfusion (MI/R) injury, therapies adjunctive to reperfusion that elicit beneficial pleiotropic effects and do not overlap with standard of care are necessary. This study found that the mitochondrial-derived peptide S14G-humanin (HNG) (2 mg/kg), an analogue of humanin, reduced infarct size i...
Published in Clinical Immunology (Orlando, Fla.)
• Severe coronavirus disease 2019 (COVID-19) cases are associated with cytokine storm. • Pro-inflammatory cytokines implicated in the sequelae signal through JAK1/JAK2. • Ruxolitinib, a JAK1/JAK2 inhibitor, could mitigate the cytokine storm in COVID-19. • Ruxolitinib may therefore have potential to reduce mortality in severe COVID-19.
Published in Mayo Clinic Proceedings: Innovations, Quality & Outcomes
An understanding of the molecular basis of liver regeneration will open new horizons for the development of novel therapies for chronic liver failure. Such therapies would solve the drawbacks associated with liver transplant, including the shortage of donor organs, long waitlist time, high medical costs, and lifelong use of immunosuppressive agents...
Published in Cellular and Molecular Gastroenterology and Hepatology
Published in Molecular Metabolism
• Impaired temperature maintenance in mice deficient in adipocyte STAT5 after acute cold exposure. • Blocked β3-adrenergic induction of lipolysis and PKA activity in BAT upon STAT5 deficiency. • Reduced respiratory capacity in primary differentiated brown adipocytes lacking STAT5. • Diminished brown remodeling of STAT5 deficient ScWAT after chronic...
Published in Acta Pharmaceutica Sinica. B
The cGAS‒STING‒TBK1 axis is appreciated as the major signaling pathway in innate immune response, which is closely linked to multiple diseases. This review summarizes the latest progress on the development of small molecule modulators targeting the cGAS‒STING‒TBK1 signaling pathway and their clinical use as a new immune stimulatory therapy. Image 1...
Published in Biochemistry and Biophysics Reports
• The expression of Reg3β is elevated in the embryonic small intestine of CFLARs Tg mice. • Reg3b −/− mice grow to adulthood without apparent abnormalities. • Dextran sulfate sodium-induced colitis is exacerbated in Reg3b −/− mice. • Deletion of Reg3b exacerbates ileitis in CFLARs Tg mice.
Published in JAAD Case Reports
