Geysens, Mathilde Huremagic, Benjamin Souche, Erika Breckpot, Jeroen Devriendt, Koenraad Peeters, Hilde Van Buggenhout, Griet Van Esch, Hilde van den Bogaert, Kris Vermeesch, Joris Robert
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BACKGROUND: A subset of developmental disorders (DD) is characterized by disease-specific genome-wide methylation changes. These episignatures inform on the underlying pathogenic mechanisms and can be used to assess the pathogenicity of genomic variants as well as confirm clinical diagnoses. Currently, the detection of these episignature requires t...
Tielemans, Birger Marain, Nora F. Kerstens, Axelle Peredo, Nicolas Coll-Llado, Montserrat Gritti, Nicola de Villemagne, Perrine Dorval, Paul Geudens, Vincent Orlitova, Michaela
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The pulmonary vasculature plays a pivotal role in the development and progress of chronic lung diseases. Due to limitations of conventional two-dimensional histological methods, the complexity and the detailed anatomy of the lung blood circulation might be overlooked. In this study, we demonstrate the practical use of optical serial block face imag...
Bleeser, Tom Joyeux, Luc Vergote, Simen Basurto, David Valenzuela, Ignacio Hubble, Talia Rose Kunpalin, Yada Emam, Doaa van de Velde, Marc Devroe, Sarah
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BACKGROUND: General anesthesia during pregnancy is not uncommon, for example, for trauma surgery, cerclage, or cesarean delivery. Current recommendations are to maintain maternal partial pressure of carbon dioxide in arterial blood (paCO2) at 30 mm Hg, which is based solely on the average maternal paCO2 in awake pregnant women. However, there is no...
Nicolas, Prescillia Minon, Celia Abdallah, Stephania Chen, Dong Rizzi, Giorgia de Coene, Yovan Liu, Weizhen Jeannin, Olivier Verbiest, Thierry Clays, Koen
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sponsorship: This research has been supported by the French National Research Agency (ANR), in the framework of the 3D-ODS research program (Project-ANR-20-CE24-0028) and by the "Region Bretagne" in the framework of the 3D-STORE research program (Project N degrees 241302-UMR6226). Y.D.C. and G.R. acknowledge the support from the Fund for Scientific...
Santana, Everton J. Cauwenberghs, Nicholas Celestin, Bettia E. Kuznetsova, Tatiana Gardner, Christopher Arena, Ross Kaminsky, Leonard A. Harber, Matthew P. Ashley, Euan Christle, Jeffrey W.
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BACKGROUND: Indexing peak oxygen uptake (VO2peak) to total body mass can underestimate cardiorespiratory fitness (CRF) in women, older adults, and individuals with obesity. The primary objective of this multicenter study was to derive and validate a body size-independent scaling metric for VO2peak. This metric was termed exercise body mass (EBM). M...
Lesurf, Robert Breckpot, Jeroen Bouwmeester, Jade Hanafi, Nour Jain, Anjali Liang, Yijing Papaz, Tanya Lougheed, Jane Mondal, Tapas Alsalehi, Mahmoud
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BACKGROUND: Congenital heart disease (CHD) is the most common congenital anomaly. Almost 90% of isolated cases have an unexplained genetic etiology after clinical testing. Non-canonical splice variants that disrupt mRNA splicing through the loss or creation of exon boundaries are not routinely captured and/or evaluated by standard clinical genetic ...
De Schepper, Maxim Koorman, Thijs Richard, Francois Christgen, Matthias Vincent-Salomon, Anne Schnitt, Stuart J. van Diest, Paul J. Zels, Gitte Mertens, Freya Maetens, Marion
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Invasive lobular carcinoma (ILC) is the second most frequent type of breast cancer (BC) and its peculiar morphology is mainly driven by inactivation of CDH1, the gene coding for E-cadherin cell adhesion protein. ILC-specific therapeutic and disease-monitoring approaches are gaining momentum in the clinic, increasing the importance of accurate ILC d...
Balali, Pargol Hart, Robert G. Smith, Eric E. Saad, Feryal Colorado, Pablo Lemmens, Robin De Marchis, Gian Marco Caso, Valeria Xu, Lizhen Heenan, Laura
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BACKGROUND AND AIMS: Cerebral microbleeds are magnetic imaging resonance (MRI) markers of hemorrhage-prone cerebral small vessel disease that predict future risk of ischemic stroke and intracranial hemorrhage (ICrH). There exist concerns about the net benefit of antithrombotic therapy in patients with microbleeds. We aimed to investigate the effect...
Manolov, Rumen Onghena, Patrick
Randomization tests represent a class of significance tests to assess the statistical significance of treatment effects in randomized single-case experiments. Most applications of single-case randomization tests concern simple treatment effects: immediate, abrupt, and permanent changes in the level of the outcome variable. However, researchers are ...
Nicolas, Prescillia Abdallah, Stephania Dok, Ahmet de Coene, Yovan Jeannin, Olivier Bellec, Nathalie Malval, Jean-Pierre Verbiest, Thierry Clays, Koen Van Cleuvenbergen, Stijn
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An original series of bipyrimidine-based chromophores featuring alkoxystyryl donor groups bearing short chiral (S)-2-methylbutyl chains in positions 4, 3,4 and 3,5, connected to electron-accepting 2,2-bipyrimidine rings, has been developed. Their linear and non-linear optical properties were studied using a variety of techniques, including one- and...