schilling-tóth, boglárka mária belcher, scott m. knotz, josefine ondrašovičová, silvia bartha, tibor tóth, istván zsarnovszky, attila kiss, dávid sándor
The sex of crocodilians is determined by the temperature to which the eggs, and hence the developing embryo are exposed during critical periods of development. Temperature-dependent sex determination is a process that occurs in all crocodilians and numerous other reptile taxa. The study of artificial incubation temperatures in different species of ...
Li, Ying Zhan, Peng Wang, Qiang Zhang, Minghua Huang, Shiming Chen, Dongfeng
Published in
Bioengineered
Sun, Xiaohua Zhang, Jizheng Li, Yi Ren, Wanlu Wang, Lijun
Published in
Bioengineered
Osteoarthritis (OA) is a rheumatic disease common in the elderly. AGEs are the end products of glycation reactions and play an important role in the development of OA. Etomidate is a general anesthesia-inducing agent recently reported to exert significant anti-inflammatory effects. The present study aims to explore the protective effect of Etomidat...
Liu, Jiuxiang Zuo, Qiang Li, Zhi Chen, Jiangqi Liu, Feng
Published in
Molecular immunology
Chondrocyte dysregulation plays a critical role in the development of osteoarthritis (OA). The pro-inflammatory cytokine interleukin-1β (IL-1β) activates chondrocytes and degrades the structural extracellular matrix (ECM). These events are the important mechanism of OA. Trelagliptin, a selective inhibitor of dipeptidyl Peptidase 4 (DPP-4) used for ...
Wang, L Mi, B Zhang, Y Yan, H Zhu, H
Published in
Human & experimental toxicology
Osteoarthritis (OA) is a disease with significant degenerative changes of articular cartilage, which is reported to be closely related to the integrity of chondrocytes extracellular matrix (ECM). Alendronate belongs to the family of bisphosphonates with promising cartilage repair function. In the present study, the effects of Alendronate on the gen...
Wang, Zhangfu Zhou, Weiwei Zheng, Guangbin Yang, Guangyong
Published in
International immunopharmacology
Osteoarthritis (OA) is a common joint disease affecting millions of elderly people worldwide. However, the mechanism of OA is complicated and remains poorly understood. Thus, a safe and effective therapeutic strategy has yet to be developed. G protein-coupled receptor 17 (GPR17) is an orphan receptor that is widely distributed in the central nervou...
Zhang, Yanjie Huang, Xiaohan Yuan, Yanhao
Published in
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Osteoarthritis (OA) impacts the quality of life in middle-aged and elderly people by inducing immobility. The severe inflammation in chondrocytes is reported to be related to the development and process of OA. The present study aims to investigate the protective effects of Apremilast on injured chondrocytes induced by interleukin-1α (IL-1α) and the...
Vasuri, Francesco Ciavarella, Carmen Fittipaldi, Silvia Pini, Rodolfo Vacirca, Andrea Gargiulo, Mauro Faggioli, Gianluca Pasquinelli, Gianandrea
Published in
Virchows Archiv : an international journal of pathology
Arterial calcification is an actively regulated process, with different morphological manifestations. Micro-RNAs emerged as potential regulators of vascular calcification; they may become novel diagnostic tools and be used for a finest staging of the carotid plaque progression. The present study aimed at characterizing the different miRNA-mRNA axes...
Papanastasopoulos, Panagiotis Panagidis, Antonios Verras, Dionysios Repanti, Maria Georgiou, George
Published in
Fertility and sterility
To present a case of complete androgen insensitivity syndrome that initially presented as incarcerated inguinal hernia and to investigate the expression of antimüllerian hormone (AMH), SOX-9 (SRY-box-containing gene 9), prostaglandin D synthase (PGDS), and androgen receptors (AR). Case report. District hospital. A 12-year-old girl with negative pas...
Papanastasopoulos, Panagiotis Repanti, Maria Damaskou, Vasileia Bravou, Vasiliki Papadaki, Helen
Published in
Virchows Archiv
SOX-9, an essential factor for male sexual development, can be induced by prostaglandin D2 in a Sry-independent mechanism. Recent data suggest that the hedgehog pathway is involved in the differentiation of normal Sertoli and Leydig cells. The purpose of our study was to investigate the mechanisms involved in the differentiation of ovarian sex cord...
