Khavinson, Vladimir Linkova, Natalia Kozhevnikova, Ekaterina Trofimova, Svetlana
Published in
Molecules
The EDR peptide (Glu-Asp-Arg) has been previously established to possess neuroprotective properties. It activates gene expression and synthesis of proteins, involved in maintaining the neuronal functional activity, and reduces the intensity of their apoptosis in in vitro and in vivo studies. The EDR peptide interferes with the elimination of dendri...
Colasuonno, Fiorella Bertini, Enrico Tartaglia, Marco Compagnucci, Claudia Moreno, Sandra
Published in
Antioxidants (Basel, Switzerland)
Riboflavin transporter deficiency (RTD) is a childhood-onset neurodegenerative disorder characterized by sensorineural deafness and motor neuron degeneration. Since riboflavin plays key functions in biological oxidation-reduction reactions, energy metabolism pathways involving flavoproteins are affected in RTD. We recently generated induced pluripo...
Yun, Ui Jeong Yang, Dong Kwon
Published in
Antioxidants
Sinapic acid (SA) is a naturally occurring phenolic compound with antioxidant properties. It also has a wide range of pharmacological properties, such as anti-inflammatory, anticancer, and hepatoprotective properties. The present study aimed to evaluate the potential pharmacological effects of SA against hypertrophic responses in neonatal rat cardi...
Jürs, Alexandra V. Völkner, Christin Liedtke, Maik Huth, Katharina Lukas, Jan Hermann, Andreas Frech, Moritz J.
Published in
International Journal of Molecular Sciences
Oxidative stress (OS) represents a state of an imbalanced amount of reactive oxygen species (ROS) and/or a hampered efficacy of the antioxidative defense system. Cells of the central nervous system are particularly sensitive to OS, as they have a massive need of oxygen to maintain proper function. Consequently, OS represents a common pathophysiolog...
Zhang, Yanfei Ho, Kevin Keaton, Jacob M Hartzel, Dustin N Day, Felix Justice, Anne E Josyula, Navya S Pendergrass, Sarah A Actkins, Ky'Era Davis, Lea K
...
Published in
American journal of obstetrics and gynecology
Polycystic ovary syndrome is the most common endocrine disorder affecting women of reproductive age. A number of criteria have been developed for clinical diagnosis of polycystic ovary syndrome, with the Rotterdam criteria being the most inclusive. Evidence suggests that polycystic ovary syndrome is significantly heritable, and previous studies hav...
Ściskalska, Milena Ołdakowska, Monika Marek, Grzegorz Milnerowicz, Halina
Published in
Antioxidants
This study was aimed at evaluating the changes in the concentration and activity of all superoxide dismutase isoenzymes (SOD1, SOD2, SOD3) in the blood of patients with acute pancreatitis (AP) and healthy subjects, taking into account the extracellular (plasma) and intracellular (erythrocyte lysate) compartment. The relationships between the activi...
Camporez, Daniela Belcavello, Luciano Almeida, Jucimara Ferreira Figueiredo Silva-Sena, Geralda Gillian Pimassoni, Lúcia Helena Sagrillo Morelato, Renato Lírio do Carmo Pimentel Batitucci, Maria de Paula, Flavia
Published in
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common type of dementia in the elderly. Although its cause is not completely known, several studies suggest that oxidative stress plays an important role in the etiology of this disease. The SIRT1 and SOD2 proteins are linked to pathways that may impair oxidative stress. ...
Jung, Yi-Deun Park, Seul-Ki Kang, Dayeon Hwang, Supyong Kang, Myoung-Hee Hong, Seung-Woo Moon, Jai-Hee Shin, Jae-Sik Jin, Dong-Hoon You, Dalsan
...
Published in
Redox biology
The use of human mesenchymal stem cells (hMSCs) in clinical applications requires large-scale cell expansion prior to administration. However, the prolonged culture of hMSCs results in cellular senescence, impairing their proliferation and therapeutic potentials. To understand the role of microRNAs (miRNAs) in regulating cellular senescence in hMSC...
Xu, Huanhuan Gan, Chunxia Gao, Ziqi Huang, Yewei Wu, Simin Zhang, Dongying Wang, Xuanjun Sheng, Jun
Published in
Frontiers in cell and developmental biology
Caffeine is chemically stable and not readily oxidized under normal physiological conditions but also has antioxidant effects, although the underlying molecular mechanism is not well understood. Superoxide dismutase (SOD) 2 is a manganese-containing enzyme located in mitochondria that protects cells against oxidative stress by scavenging reactive o...
Sullivan, Michelle N Brill, Samuel A Mangus, Lisa M Jeong, Yea Ji Solis, Clarisse V Knight, Audrey C Colantuoni, Carlo Keceli, Gizem Paolocci, Nazareno Queen, Suzanne E
...
Published in
Journal of neuropathology and experimental neurology
HIV-associated neurocognitive disorders (HAND) remain prevalent despite implementation of antiretroviral therapy (ART). Development of HAND is linked to mitochondrial dysfunction and oxidative stress in the brain; therefore, upregulation of antioxidant defenses is critical to curtail neuronal damage. Superoxide dismutase 2 (SOD2) is a mitochondrial...