Luan, Junjun Fu, Jingqi Wang, Dongdong Jiao, Congcong Cui, Xiangfei Chen, Chengjie Liu, Dan Zhang, Yixiao Wang, Yanqiu Yuen, Peter S T
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Published in
Molecular therapy. Nucleic acids
We investigated whether microRNA-150 (miR-150)-based RNA interference (RNAi) ameliorates tubular injury and tubulointerstitial fibrosis. Mice injected with folic acid developed tubulointerstitial fibrosis at day 30. miR-150 levels were increased at day 7 and peaked at day 30. At day 30, protein levels of α-smooth muscle actin, fibronectin (FN), and...
Bernal, Susana Lopez-Sanz, Laura Jimenez-Castilla, Luna Prieto, Ignacio Melgar, Ana La Manna, Sara Martin-Ventura, Jose Luis Blanco-Colio, Luis Miguel Egido, Jesus Gomez-Guerrero, Carmen
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Published in
British journal of pharmacology
Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by chronic inflammation, oxidative stress and proteolytic activity in the aortic wall. Targeting JAK/signal transducer and activator of transcription (JAK/STAT) pathway is a promising strategy for chronic inflammatory diseases. We investigated the vasculo-protective role of s...
Bernal, Susana Lopez-Sanz, Laura Jimenez-Castilla, Luna Prieto, Ignacio Melgar, Ana La Manna, Sara Martin-Ventura, Jose Luis Blanco-Colio, Luis Miguel Egido, Jesus Gomez-Guerrero, Carmen
...
Published in
British journal of pharmacology
Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by chronic inflammation, oxidative stress, and proteolytic activity in the aortic wall. Targeting Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is a promising strategy for chronic inflammatory diseases. We investigated the vasculoprotective ...
Wahid, Braira
Published in
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Hepatitis C virus (HCV) is a global health problem, with an estimated bioburden of >180 million. Every year about 350,000 people die from HCV-associated liver complications such as cirrhosis and cancer (e.g., hepatocellular carcinoma). Pakistan has the second highest prevalence of HCV. Treatment of this life-threatening disease has been a challenge...
Qing, Xiang Tan, Guo-lin Liu, Huo-wang Li, Wei Ai, Jin-gang Xiong, Shan-shan Yang, Meng-qing Wang, Tian-sheng
Published in
Journal of Experimental & Clinical Cancer Research
Nasopharyngeal carcinoma (NPC) is an epithelial cancer emerging from the lining of nasopharyngeal mucosa, with extremely frequent occurrence in east and southeast Asia. For the purpose of exploring roles of the dysregulated long non-coding RNA (lncRNA) in NPC, we identified a novel lncRNA LINC00669 with an apparent negative correlation to the overa...
Khan, Md Gulam Musawwir Ghosh, Amit Variya, Bhavesh Santharam, Madanraj Appiya Ihsan, Awais Ullah Ramanathan, Sheela Ilangumaran, Subburaj
Published in
BMC Cancer
BackgroundSOCS1 and SOCS3 genes are considered tumor suppressors in hepatocellular carcinoma (HCC) due to frequent epigenetic repression. Consistent with this notion, mice lacking SOCS1 or SOCS3 show increased susceptibility to diethylnitrosamine (DEN)-induced HCC. As SOCS1 and SOCS3 are important regulators of cytokine and growth factor signaling,...
Du, Yinping Yang, Fan Wang, Qiuxia Xu, Nuo Xie, Yizhang Chen, Sujuan Qin, Tao Peng, Daxin
Published in
Virology Journal
BackgroundAlthough influenza A virus (IAV) employs diverse strategies to evade IFN responses by inhibiting the synthesis of IFN, how IAV regulates signaling downstream of IFN is incompletely understood.MethodsIn this study, we used Western blot-based protein analysis coupled with RT-qPCR, overexpression and RNA interference to investigate the regul...
Wang, Changlin Shan, Lingling Qu, Shuxin Xue, Mei Wang, Keliang Fu, Fang Wang, Lu Wang, Ziqi Feng, Li Xu, Wanhai
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Published in
Frontiers in Microbiology
Porcine epidemic diarrhea virus (PEDV) is an economically important pathogen that has evolved several mechanisms to evade type I IFN responses. Type III interferon (IFN-λ), an innate cytokine that primarily targets the mucosal epithelia, is critical in fighting mucosal infection in the host and has been reported to potently inhibit PEDV infection i...
Zhang, Lei Qu, Yan-Nv Zhang, He-Yang Wu, Zhen-Yang Li, Zhong-Li Guo, Wan-Bei Wang, Qi-Ben Fang, Nan-Zhu Jiang, Xiao-Xia
Published in
International Journal of Stem Cells
Background and Objectives The effective use of MSCs for the treatment of some B cell-mediated immune diseases is quite limited. The main reason is that the immunomodulatory effects of mesenchymal stem cells (MSCs) on B cells are unclear, and their underlying mechanisms have not been fully explored. Methods and Results By co-culturing B cells with M...
Chen, Feng He, Dongyun Yan, Bailing
Published in
Dose-Response
Background: Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated immune-inflammatory response mainly affecting nasal mucosa. Apigenin, a flavonoid, has been documented to possess promising anti-allergic potential. Aim: To determine the potential mechanism of action of apigenin against ovalbumin (OVA)-induced AR by assessing various behavior...
