Tona, Risa Lopez, Ivan A Fenollar-Ferrer, Cristina Faridi, Rabia Anselmi, Claudio Khan, Asma A Shahzad, Mohsin Morell, Robert J Gu, Shoujun Hoa, Michael
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Published in
Genes
Human pathogenic variants of TBC1D24 are associated with clinically heterogeneous phenotypes, including recessive nonsyndromic deafness DFNB86, dominant nonsyndromic deafness DFNA65, seizure accompanied by deafness, a variety of isolated seizure phenotypes and DOORS syndrome, characterized by deafness, onychodystrophy, osteodystrophy, intellectual ...
Peacock, AJ Ling, Y Johnson, MK Kiely, DG Condliffe, R Elliot, CA Gibbs, JSR Howard, LS Pepke-Zaba, J Sheares, KKK
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Patients classified as idiopathic pulmonary arterial hypertension (defined as Group 1 on European Respiratory Society (ERS)/European Cardiac Society (ESC) criteria) may have evidence of minor co-existing lung disease on thoracic computed tomography. We hypothesised that these idiopathic pulmonary arterial hypertension patients (IPAH lung disease) a...
Celli, BR Wedzicha, JA
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; COPD led to 3.2 million deaths in 2017, a toll expected to reach 4.4 million yearly by 2040.1,2 With a worldwide prevalence of 10.1%, COPD afflicts many people in low-income, middle-income, and wealthy countries (Figure 1), and years of life lost prematurely...
Liu, Charles Putman, Barbara Singh, Ankura Zeig-Owens, Rachel Hall, Charles B. Schwartz, Theresa Webber, Mayris P. Cohen, Hillel W. Fazzari, Melissa J. Prezant, David J.
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Published in
International Journal of Environmental Research and Public Health
Fire Department of the City of New York (FDNY) firefighters experienced intense dust exposure working at the World Trade Center (WTC) site on and after 11/9/2001 (9/11). We hypothesized that high-intensity WTC exposure caused abnormalities found on chest computed tomography (CT). Between 11/9/2001–10/9/2018, 4277 firefighters underwent a clinically...
van Dort, Mayke J Driessen, Johanna Hm Romme, Elisabeth Apm Geusens, Piet Willems, Paul C Smeenk, Frank Wjm Wouters, Emiel Fm van den Bergh, Joop Pw
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Greater kyphosis angles lead to increased loading on vertebral bodies in computational models. However, results about the relationship between severity of kyphosis and incident vertebral fracture (VF) risk have been conflicting. Therefore, the aim of this study was to evaluate associations between 1) prevalent VFs and severity of kyphosis, and 2) s...
Tregay, N Begg, M Cahn, A Farahi, N Povey, K Madhavan, S Simmonds, R Gillett, D Solanki, C Wong, A
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RATIONALE: There is a need to develop imaging protocols which assess neutrophilic inflammation in the lung. AIM: To quantify whole lung neutrophil accumulation in (1) healthy volunteers (HV) following inhaled lipopolysaccharide (LPS) or saline and (2) patients with COPD using radiolabelled autologous neutrophils and single-photon emission computed ...
Trofor, AC Papadakis, S Lotrean, LM Radu-Loghin, C Eremia, M Mihaltan, F Driezen, P Kyriakos, CN Mons, U Demjen, T
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Introduction: The aim of this study was to examine knowledge of health effects of smoking and the impact of cigarette package warnings among tobacco users from six European Union (EU) Member States (MS) immediately prior to the introduction of the EU Tobacco Products Directive (TPD) in 2016 and to explore the interrelationship between these two fac...
Ribeiro, L Ind, PW
Increasing cannabis use and legalisation highlights the paucity of data we have on the safety of cannabis smoking for respiratory health. Unfortunately, concurrent use of tobacco among marijuana smokers makes it difficult to untangle individual effect of marijuana smoking. Chronic cannabis only smoking has been shown in large cohort studies to redu...
Piirtola, Maarit Jelenkovic, Aline Latvala, Antti Sund, Reijo Honda, Chika Inui, Fujio Watanabe, Mikio Tomizawa, Rie Iwatani, Yoshinori Ordoñana, Juan R
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Published in
PloS one
Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we analysed data from twin pairs in which the co-twins differed by their smoking behaviour to evaluate if the association between smoking and body ma...
Ward, HA Whitman, J Muller, DC Johansson, M Jakszyn, P Weiderpass, E Palli, D Fanidi, A Vermeulen, R Tjønneland, A
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BACKGROUND: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data an...
