Minatogawa, Mari Unzaki, Ai Morisaki, Hiroko Syx, Delfien Sonoda, Tohru Janecke, Andreas R Slavotinek, Anne Voermans, Nicol C Lacassie, Yves Mendoza-Londono, Roberto
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Published in
Journal of medical genetics
Musculocontractural Ehlers-Danlos syndrome is caused by biallelic loss-of-function variants in CHST14 (mcEDS-CHST14) or DSE (mcEDS-DSE). Although 48 patients in 33 families with mcEDS-CHST14 have been reported, the spectrum of pathogenic variants, accurate prevalence of various manifestations and detailed natural history have not been systematicall...
Pei, Yuanchao Zhang, Yaxin Ma, Jie Fan, Maohong Zhang, Suojiang Wang, Jianji
Ionic liquids have continued to attract huge interest in modern science and technology in the last decade. The early stages of ionic liquids research have mainly focused on alternative green solvents for traditional volatile organic solvents due to the low volatility of ionic liquids. However, benefiting from their designable structure and properti...
Pei, Yuanchao Zhang, Yaxin Ma, Jie Fan, Maohong Zhang, Suojiang Wang, Jianji
Ionic liquids have continued to attract huge interest in modern science and technology in the last decade. The early stages of ionic liquids research have mainly focused on alternative green solvents for traditional volatile organic solvents due to the low volatility of ionic liquids. However, benefiting from their designable structure and properti...
Nasir, N Jannah M Corrias, Alberto Heemskerk, Hans Ang, Eng Tat Jenkins, Julia H Sebastin, SJ Tucker-Kellogg, Lisa
10.1098/rsif.2021.0631 / JOURNAL OF THE ROYAL SOCIETY INTERFACE / 19 / 187 / completed / completed
Maschalidi, Sophia Mehrotra, Parul Keçeli, Burcu Nur De Cleene, Hannah Lecomte, Kim Van der Cruyssen, Renée Janssen, Pauline Pinney, Jonathan van Loo, Geert Elewaut, Dirk
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Chronic non-healing wounds are a major complication of diabetes, which affects 1 in 10 people worldwide. Dying cells in the wound perpetuate the inflammation and contribute to dysregulated tissue repair1-3. Here we reveal that the membrane transporter SLC7A11 acts as a molecular brake on efferocytosis, the process by which dying cells are removed, ...
Reich, K. Iversen, L. Puig, L. Lambert, Johannes Mrowietz, U. Kaplan Saday, K. Warren, R.B.
Background Brodalumab is a monoclonal antibody that blocks multiple interleukin (IL)-17 family cytokines by binding to the shared A subunit of the IL-17 receptor. In Phase 3 trials, brodalumab provided high levels of skin clearance through 52 weeks in patients with moderate-to-severe psoriasis and was generally well tolerated. Objectives To assess ...
Devriendt, Nausikaa Rodrigues, Tania Vandenabeele, Sophie Paepe, Dominique Stock, Emmelie De Rooster, Hilde
Background Skin and coat quality can reflect nutritional deficiencies in humans and dogs with liver diseases. Hypothesis/Objectives Determine skin and coat quality based on a scoring protocol and skin biopsies in dogs with an extrahepatic portosystemic shunt (EHPSS), and determine total lipid concentrations in hairs of dogs at time of surgery and 3...
Gefen, Amit Alves, Paulo Beeckman, Dimitri Cullen, Breda Lazaro Martinez, José Luis Lev-Tov, Hadar Avihai Najafi, Bijan Santamaria, Nick Sharpe, Andrew Swanson, Terry
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Significance: Wounds of all types remain one of the most important, expensive, and common medical problems, for example, up to approximately two-thirds of the work time of community nurses is spent on wound management. Many wounds are treated by means of dressings. The materials used in a dressing, their microarchitecture, and how they are composed...
Bikle, Daniel D
Our predominant understanding of the actions of vitamin D involve binding of its ligand, 1,25(OH)D, to the vitamin D receptor (VDR), which for its genomic actions binds to discrete regions of its target genes called vitamin D response elements. However, chromatin immunoprecipitation-sequencing (ChIP-seq) studies have observed that the VDR can bind ...
Herdman, MT Cordery, R Karo, B Purba, AK Begum, L Lamagni, T Kee, C Balasegaram, S Sriskandan, S
Objectives In response to increasing incidence of scarlet fever and wider outbreaks of group A streptococcal infections in London, we aimed to characterise the epidemiology, symptoms, management and consequences of scarlet fever, and to identify factors associated with delayed diagnosis. Design and setting Cross-sectional community-based study of c...
