Metmyoglobin (MbFeIII), a major form of dietary iron, is an efficient inducer of lipid and protein oxidation. Indeed, MbFeIII is able to cleave hydrogen peroxide and lipid hydroperoxides with subsequent formation of ferrylmyoglobin (MbFeIV = O) and lipid oxyl and peroxyl radicals. In the first part of this work, the mechanism of the reaction betwee...
This work provides a quantitative kinetic analysis of oxidative pathways involving linoleic acid and the common dietary antioxidant quercetin (flavonoid), both bound to human serum albumin (HSA). In particular, it is shown that quercetin, although embedded in drug site I, is oxidized as quickly as free quercetin under a flux of hydrophilic peroxyl ...
Although LDL esterified polyunsaturated fatty acids (PUFA) contribute largely to the pool of oxidizable lipids in plasma, they coexist with a non-negligible content of free PUFA. In some pathological conditions, the free PUFA/albumin ratio becomes abnormally elevated. Modeling was performed in a system constituted of linoleic acid bound to human se...
An efficient RP-HPLC method was developed for the detection of the oxidation products derived from the AAPH-initiated peroxidation of linoleic acid bound to human serum albumin. Diode array UV-detection allowed the quantification at 234 nm of four regioisomeric hydroperoxyoctadecadienoic acids (HPODE) and four hydroxyoctadecadienoic acids (HODE) wh...
Published in Metabolism: clinical and experimental
Published in Surgery, gynecology & obstetrics
Published in The Journal of clinical investigation
Published in American journal of diseases of children (1960)
Published in American journal of surgery
Published in The Journal of pediatrics
