Nadim, Mitra K. Forni, Lui G. Mehta, Ravindra L. Connor, Michael J. Jr Liu, Kathleen D. Ostermann, Marlies Rimmelé, Thomas Zarbock, Alexander Bell, Samira Bihorac, Azra
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Published in
Nature Reviews Nephrology
COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and is an independent risk factor for all-cause in-hospital death in patients with COVID-19. This Consensus Statement from the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI and for areas of future researc...
Luz, C F Vollmer, M Decruyenaere, J Nijsten, M W Glasner, C Sinha, B
Published in
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Machine learning (ML) is increasingly being used in many areas of health care. Its use in infection management is catching up as identified in a recent review in this journal. We present here a complementary review to this work. To support clinicians and researchers in navigating through the methodological aspects of ML approaches in the field of i...
Nijman, R Joergensen, R Levin, M Herberg, J Maconochie, I
Objective: To study warning signs of serious infections in febrile children presenting to PED, ascertain their risk of having sepsis, and evaluate their management. Design: Prospective observational study. Setting: A single pediatric emergency department (PED). Participants: Febrile children, aged 1 month−16 years, with >= 1 warning signs of sepsis...
Russell, JA Gordon, AC Williams, MD Boyd, JH Walley, KR Kissoon, N
After fluid administration for vasodilatory shock, vasopressors are commonly infused. Causes of vasodilatory shock include septic shock, post-cardiovascular surgery, post-acute myocardial infarction, postsurgery, other causes of an intense systemic inflammatory response, and drug -associated anaphylaxis. Therapeutic vasopressors are hormones that a...
Vandewalle, Jolien Libert, Claude
Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic responses to infection, thereby compromising host homeostasis. Activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequently adrenocortical glucocorticoid (GC) production during sepsis are important regulatory processes to maintain homeostasis. Multip...
De Bus, Liesbet Depuydt, Pieter Steen, Johan Dhaese, Sofie De Smet, Ken Tabah, Alexis Akova, Murat Cotta, Menino Osbert De Pascale, Gennaro Dimopoulos, George
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Published in
Intensive care medicine
The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 following treatment initiation. Adult ICU patients receiving empirical antimicrobial therapy for bacterial infection were studied in a prospect...
Ibarz, Mercedes Boumendil, Ariane Haas, Lenneke E. M. Irazabal, Marian Flaatten, Hans de Lange, Dylan W. Morandi, Alessandro Andersen, Finn H. Bertolini, Guido Cecconi, Maurizio
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Published in
Annals of Intensive Care
BackgroundThe number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determine...
Vanderhaeghen, Tineke Vandewalle, Jolien Libert, Claude
Published in
The FEBS journal
Sepsis is a highly heterogeneous syndrome that is caused by an imbalanced host response to infection. Despite huge investments, sepsis remains a contemporary threat with significant burden on health systems. Vascular dysfunction and elevated oxygen consumption by highly metabolically active immune cells result in tissue hypoxia during inflammation....
Caro, Luzelena Nicolau, David P De Waele, Jan J Kuti, Joseph L Larson, Kajal B Gadzicki, Elaine Yu, Brian Zeng, Zhen Adedoyin, Adedayo Rhee, Elizabeth G
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Published in
Journal of Antimicrobial Chemotherapy
Objectives Ceftolozane/tazobactam is approved for hospital-acquired/ventilator-associated bacterial pneumonia at double the dose (i.e. 2 g/1 g) recommended for other indications. We evaluated the bronchopulmonary pharmacokinetic/pharmacodynamic profile of this 3 g ceftolozane/tazobactam regimen in ventilated pneumonia patients. Methods This was an ...
Van Looveren, Kelly Wallaeys, Charlotte Libert, Claude
Published in
Current opinion in pharmacology
Glucocorticoids (GCs) are steroid hormones characterized by their anti-inflammatory and immunosuppressive nature. Although GCs are very commonly prescribed, in several diseases, including sepsis, their clinical treatment is hampered by side effects and by the occurrence of glucocorticoid resistance (GCR). Sepsis is defined as a life-threatening org...
