Nieste, Ine Franssen, Wouter M A Duvivier, Bernard M F M Spaas, Jan Savelberg, Hans H C M Eijnde, Bert O
Published in
Disability and rehabilitation
Persons with Multiple Sclerosis (PwMS) are physically inactive and spend more time in sedentary behaviours than healthy persons, which increases the risk of developing cardiometabolic diseases. In this randomised crossover study, the cardiometabolic health effects of replacing sitting with light-intensity physical activity (LIPA) and exercise (EX) ...
Nieste, Ine; Franssen, Wouter MA; Duvivier, Bernard MFM; 143349; Spaas, Jan; Savelberg, Hans HCM; Eijnde, Bert O;
PURPOSE: Persons with Multiple Sclerosis (PwMS) are physically inactive and spend more time in sedentary behaviours than healthy persons, which increases the risk of developing cardiometabolic diseases. In this randomised crossover study, the cardiometabolic health effects of replacing sitting with light-intensity physical activity (LIPA) and exerc...
Karschuck, Tobias; Schmidt, Stefan; Achtsnicht, Stefan; Poghossian, Arshak; Wagner, Patrick; 7368; Schoening, Michael Josef;
status: Published online
Velozo, Joana De Calheiros; Vaessen, Thomas; 106722; Lafit, Ginette; 119584; Claes, Stephan; 15133; Myin-Germeys, Inez; 103850;
Typical measures of laboratory reactivity (i.e. difference between control and stress) and recovery (i.e. difference between stress and post-stress) were compared with a conventional measure of daily-life reactivity, best known as event-related stress. Fifty-three healthy individuals between 19 and 35 years of age took part in a laboratory session ...
Frutos-Rincon, Laura; Luna, Carolina; Aleixandre-Carrera, Fernando; Velasco, Enrique; Diaz-Tahoces, Ariadna; Meseguer, Victor; Gallar, Juana; Acosta, M Carmen;
The role of TRPA1 in the thermosensitivity of the corneal cold thermoreceptor nerve endings was studied in young and aged mice. The contribution of the TRPA1-dependent activity to basal tearing and thermally-evoked blink was also explored. The corneal cold thermoreceptors' activity was recorded extracellularly in young (5-month-old) and aged (18-mo...
Borderias-Villarroel, Elena; Dastarac, Margerie Huet; Barragan-Montero, Ana Maria; Helander, Rasmus; Holmstrom, Mats; Geets, Xavier; Sterpin, Edmond; 106731;
PURPOSE: Automated treatment planning strategies are being widely implemented in clinical routines to reduce inter-planner variability, speed up the optimization process, and improve plan quality. This study aims to evaluate the feasibility and quality of intensity-modulated proton therapy (IMPT) plans generated with four different knowledge-based ...
Gomez-Escribano, Ana P; Mora-Martinez, Carlos; Roca, Marta; Walker, Denise S; Panadero, Joaquin; Sequedo, Maria D; Saini, Ratni; Knoelker, Hans-Joachim; Blanca, Jose; Burguera, Juan;
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Alzheimer's, Parkinson's and Huntington's diseases can be caused by mutations that enhance protein aggregation, but we still do not know enough about the molecular players of these pathways to develop treatments for these devastating diseases. Here, we screen for mutations that might enhance aggregation in Caenorhabditis elegans, to investigate the...
Delis, Manthos D; Dioikitopoulos, Evangelos V; Ongena, Steven; 28992;
status: published
Heylen, Elien; 123617; Verstraete, Paulien; 147141; Van Aerschot, Linde; 133658; Geeraerts, Shauni L; Venken, Tom; 65005; Timcheva, Kalina; 142966; Nittner, David; 63864; Verbeeck, Jelle; Royaert, Jonathan; 71974; Gijbels, Marion;
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BACKGROUND: One-third of cancers activate endogenous synthesis of serine/glycine, and can become addicted to this pathway to sustain proliferation and survival. Mechanisms driving this metabolic rewiring remain largely unknown. METHODS: NKX2-1 overexpressing and NKX2-1 knockdown/knockout T-cell leukaemia and lung cancer cell line models were establ...
Schick, Anita; van Winkel, Ruud; 88156; Lin, Bochao D; Luykx, Jurjen J; de Zwarte, Sonja MC; van Eijk, Kristel R; Investigators, Group; Myin-Germeys, Inez; 103850; Reininghaus, Ulrich;
BACKGROUND: There is evidence for a polygenic contribution to psychosis. One targetable mechanism through which polygenic variation may impact on individuals and interact with the social environment is stress sensitization, characterized by elevated reactivity to minor stressors in daily life. The current study aimed to investigate whether stress r...
