A two-step estimation procedure for semiparametric mixture cure models
status: accepted
Optimal sensor placement for the spatial reconstruction of sound fields
status: published
Breeding for resilience in finishing pigs can decrease tail biting, lameness and mortality
BACKGROUND: Previous research showed that deviations in longitudinal data are heritable and can be used as a proxy for pigs' general resilience. However, only a few studies investigated the relationship between these resilience traits and other traits related to resilience and welfare. Therefore, this study investigated the relationship between res...
A FRAMEWORK FOR ANALYSING LONGITUDINAL DATA INVOLVING TIME-VARYING COVARIATES
status: accepted
Large dataset analyses advance knowledge of seed ecology and evolutionary biology
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status: published
Enhancing groundwater recharge in drinking water protection zones in Flanders (Belgium): A novel approach to assess stor...
status: published
Random-Effects Substitution Models for Phylogenetics via Scalable Gradient Approximations
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Phylogenetic and discrete-trait evolutionary inference depend heavily on an appropriate characterization of the underlying character substitution process. In this paper, we present random-effects substitution models that extend common continuous-time Markov chain models into a richer class of processes capable of capturing a wider variety of substi...
A comparison of hyperparameter tuning procedures for clinical prediction models: A simulation study
Tuning hyperparameters, such as the regularization parameter in Ridge or Lasso regression, is often aimed at improving the predictive performance of risk prediction models. In this study, various hyperparameter tuning procedures for clinical prediction models were systematically compared and evaluated in low-dimensional data. The focus was on out-o...
A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKD...
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Genome-wide association studies (GWAS) identified thousands of genetic variants linked to phenotypic traits and disease risk. However, mechanistic understanding of how GWAS variants influence complex morphological traits and can, in certain cases, simultaneously confer normal-range phenotypic variation and disease predisposition, is still largely l...
What is a trait? Lessons from the human chin
The chin, a distinguishing feature of Homo sapiens, has sparked ongoing debates regarding its evolutionary origins and adaptive significance. We contend that these controversies stem from a fundamental disagreement about what constitutes a well-defined biological trait, a problem that has received insufficient attention despite its recognized impor...
