Published in Inflammopharmacology
The nutritional status of a patient can be critical for the efficacy of other pharmaceuticals, especially organic antibiotics, to treat viral pandemics. There may be political and scientific difficulties in achieving a constructive synergy of nutritional and prescribed allopathic remedies. For adequate treatment, timelines may need to extend well b...
Published in Computers in Biology and Medicine
• Screened a database of 1806 small molecule compounds from DrugBank for potential SARS CoV-2 E protein inhibitors. • Tested four FDA-approved drugs Tetinoin, Mefenamic acid, Ondansetron and Artemether as SARS CoV-2 E protein inhibitors . • Used a combination of molecular docking, MD simulations and MM-PBSA analysis to propose Tretinoin as a promis...
Published in Current Treatment Options in Neurology
Purpose of ReviewTo describe the possible neuroinvasion pathways of Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2), the virus responsible for the Coronavirus disease-19 (Covid-19) pandemic.Recent FindingsWe present data regarding the family of Coronaviruses (CoVs) and the central nervous system (CNS), and describe parallels be...
Published in Dermatologic therapy
A severe cutaneous drug reaction resembling acute generalized exanthematous pustulosis resulting from ingestion of hydroxychloroquine has been documented. It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. Give...
This presentation, hosted by the Community Engagement and Research Section, University of Massachusetts Medical School Center for Clinical and Translational Science, describes the development of siRNA-based approaches for modulation of COVID-19 in the lung in a three-month time frame. This talk was the second in the COVID-19 Research Community Foru...
This presentation about the biology of Coronaviruses was presented virtually to the RNA Biology Journal Club at the University of Massachusetts Medical School on April 7, 2020.
The rapidly emerging SARS-2-CoV (SARS-2) has been spreading through China and entering many parts of the world with easy human-to-human transmission and thousands of deaths. Development of a vaccine, and a vaccine which can be quickly deployed on a global scale, is no longer merely a discussion or part of a debate whether such a vaccine is ultimate...
We are public health scientists who have closely followed the emergence of 2019 novel coronavirus disease (COVID-19) and are deeply concerned about its impact on global health and wellbeing. We have watched as the scientists, public health professionals, and medical professionals of China, in particular, have worked diligently and effectively to ra...
