Contexte : les injections intravitréennes (IVT) d'anti-VEGF sont utilisées pour traiter plusieurs pathologies qui peuvent altérer définitivement le pronostic visuel. Leur fréquence est en constante augmentation et elles sont souvent appliquées sur des temps longs. Les patients rapportent fréquemment après les IVT des symptômes douloureux de séchere...
Le microbiote intestinal joue un rôle central pour son hôte. Il participe à la protection de l’hôte via sa fonction barrière, le métabolisme des nutriments, la production de neurotransmetteurs ainsi que le développement et la maturation du système immunitaire. Les pathologies oculaires sont multifactorielles et présentent des composantes environnem...
Sjögren’s syndrome is an immune system disorder with two common symptoms, dry eyes and a dry mouth. The discomfort of dry eye symptoms affects daily lives, results in 30% activity impairment and affects 95% of Sjögren patients [1]. Dry eye disease (DED) is also an independent multifactorial disorder with a prevalence of up to 50% [2]. The ocular su...
Published in Journal francais d'ophtalmologie
In parallel to ocular surface disease in dry eye there is often a dysfunctionality of the lacrimal gland apparatus. The functionality of the lacrimal gland is of major importance for maintenance of ocular surface integrity and health, even in conditions of enhanced stimulation and secretion requirements. Such enhanced secretion demands can push the...
Dry eye disease (DED) is a multifactorial disease of the ocular surface, often leading to chronic ocular pain, with limited efficient treatment options. In numerous cases, it can be associated with neuropathic corneal pain (NCP), even more difficult to manage. Treating NCP is highly challenging, and there is still a current lack of available topica...
La sécheresse oculaire est une pathologie multifactorielle de la surface oculaire dont les mécanismes impliquent l’instabilité du film lacrymal, l’hyperosmolarité, la mort cellulaire et l’inflammation. Ce travail de thèse s’est intéressé aux rôles des lipides dans la physiopathologie de la sécheresse oculaire. Dans ce contexte, des développements a...
Published in Journal francais d'ophtalmologie
To investigate the effect of systemic anti-androgen drugs on tear function tests and the ocular surface. Sixty-four male subjects were included in this study. Subjects who were on anti-androgen treatment for prostate cancer (Group A, n: 31) and those who had received only surgical treatment for prostate cancer (Group B, n: 17) were recruited from t...
L'œil est un organe très sensible et complexe du corps humain. La cornée est en contact direct avec l'environnement extérieur et peut être soumise à de nombreuses agressions et pathologies. Pour les traiter, de nombreuses formes ophtalmiques sont développées et présentes sur le marché. Cependant, en raison de divers mécanismes de défense et d’une c...
Published in Journal francais d'ophtalmologie
Dry eye syndrome caused by Meibomian gland dysfunction (MGD) is a common disease in the general population and impairs quality of life. Intense Pulsed Light (IPL) has mainly been used in dermatology for the treatment of skin disorders, and more recently for MGD-related dry eye. The objective of our study is to evaluate the efficacy and tolerability...
Published in Journal francais d'ophtalmologie
Tumor necrosis factor-inducible gene 6 protein (TSG-6) is member of the hyaluronan-binding protein family (hyaladherins) to which CD44 also belongs. Inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin-1 (IL-1) stimulate TSG-6 production. Recently, however, externally applied TSG-6 has been shown to be effective in the tre...
