Gaburjakova, Jana Krejciova, Eva Gaburjakova, Marta
Published in
Pflugers Archiv : European journal of physiology
Many proteins are phosphorylated at more than one phosphorylation site to achieve precise tuning of protein function and/or integrate a multitude of signals into the activity of one protein. Increasing the number of phosphorylation sites significantly broadens the complexity of molecular mechanisms involved in processing multiple phosphorylation si...
Pelletier, Laurent Petiot, Anne Brocard, Julie Giannesini, Benoit Giovannini, Diane Sanchez, Colline Travard, Lauriane Chivet, Mathilde Beaufils, Mathilde Kutchukian, Candice
...
Published in
Acta Neuropathologica Communications
Mutations in the RYR1 gene, encoding the skeletal muscle calcium channel RyR1, lead to congenital myopathies, through expression of a channel with abnormal permeability and/or in reduced amount, but the direct functional whole organism consequences of exclusive reduction in RyR1 amount have never been studied. We have developed and characterized a ...
Nakamura-Maruyamaa, Emi Kai, Risa Himia, Naoyuki Okabe, Naohiko Narita, Kazuhiko Miyazaki, Tetsuji Aoki, Shozo Miyamoto, Osamu
Published in
Brain stimulation
Electroconvulsive therapy (ECT) is effective for treating depression. However, the mechanisms underlying the antidepressant effects of ECT remain unknown. Depressed patients exhibit abnormal Ca2+ kinetics. Early stages of the intracellular Ca2+ signaling pathway involve the release of Ca2+ from the endoplasmic reticulum (ER) via Ca2+ release channe...
Yang, Hua-Qian Zhou, Peng Wang, Li-Peng Zhao, Yan-Ting Ren, Yu-Jie Guo, Yun-Bo Xu, Ming Wang, Shi-Qiang
Published in
Cardiovascular research
β-adrenergic receptors (βARs) play pivotal roles in regulating cardiac excitation-contraction (E-C) coupling. Global signalling of β1ARs up-regulates both the influx of Ca2+ through sarcolemmal L-type Ca2+ channels (LCCs) and the release of Ca2+ from the sarcoplasmic reticulum (SR) through the ryanodine receptors (RyRs). However, we recently found ...
Sleiman, Yvonne Souidi, Monia Kumar, Ritu Yang, Ellen Jaffré, Fabrice Zhou, Ting Bernardin, Albin Reiken, Steve Cazorla, Olivier Kajava, Andrey V.
...
Published in
EBioMedicine
Background While mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia (CPVT), its association with polymorphic ventricular tachycardia (PMVT) occurring at rest is unclear. We aimed at constructing a patient-specific human-induced pluripotent stem cell...
Nikolaienko, Roman Bovo, Elisa Rebbeck, Robyn T. Kahn, Daniel Thomas, David D. Cornea, Razvan L. Zima, Aleksey V.
Published in
Redox Biology
• Oxidative stress promotes cardiac ryanodine receptor (RyR2) intersubunit crosslinking. • Human RyR2 crosslinking promotes Ca leak and calmodulin dissociation. • RyR2 C3602 is not involved in crosslinking, slightly affects calmodulin binding. • RyR2 crosslinking is an important pathology related RyR2 regulator.
Grogan, Alyssa Coleman, Andrew Joca, Humberto Granzier, Henk Russel, Mark W. Ward, Christopher W. Kontrogianni-Konstantopoulos, Aikaterini...
Published in
Basic Research in Cardiology
Obscurin comprises a family of giant modular proteins that play key structural and regulatory roles in striated muscles. Immunoglobulin domains 58/59 (Ig58/59) of obscurin mediate binding to essential modulators of muscle structure and function, including canonical titin, a smaller splice variant of titin, termed novex-3, and phospholamban (PLN). I...
Sun, Liang Wei, Huafeng
Published in
Cellular and molecular neurobiology
Progressive neuronal demise is a key contributor to the key pathogenic event implicated in many different neurodegenerative disorders (NDDs). There are several therapeutic strategies available; however, none of them are particularly effective. Targeted neuroprotective therapy is one such therapy, which seems a compelling option, yet remains challen...
Denniss, Amanda L. Dashwood, Alexander M. Molenaar, Peter Beard, Nicole A.
Published in
Biophysical Reviews
Excitation-contraction coupling links excitation of the sarcolemmal surface membrane to mechanical contraction. In the heart this link is established via a Ca2+-induced Ca2+ release process, which, following sarcolemmal depolarisation, prompts Ca2+ release from the sarcoplasmic reticulum (SR) though the ryanodine receptor (RyR2). This substantially...
Huang 黄镜梅, Jing-Mei Rao 饶聪, Cong Wang 王帅, Shuai He 何林凤, Lin-Feng Zhao 赵思琪, Si-Qi Zhou 周丽琪, Li-Qi Zhao 赵云霞, Yun-Xia Yang 杨凤霞, Feng-Xia Gao 高聪芬, Cong-Fen Wu 吴顺凡, Shun-Fan
...
Published in
Insect biochemistry and molecular biology
Diamide resistant phenotypes have evolved in the field and the resistance has been attributed to target-site mutations in some lepidopteran pests. In this study, we documented the resistance status of Chilo suppressalis to chlorantraniliprole during 2016-2018 in seven provinces of China. To investigate the possible role of target-site mutations as ...
