Published in Angewandte Chemie (International Ed. in English)
Metallacycles embrace carbon nanotubes: The encapsulation of SWNTs within a Pd‐based metallosquare featuring N‐heterocyclic‐carbene ligands is described. It is found that the formation of MINTs with this type of metallo‐assembly is very sensitive to structural variations, but with the correct one it proceeds successfully both by “clipping” and “thr...
Published in Angewandte Chemie (International Ed. in English)
A rotaxane‐based platform is introduced for the design of multi‐modality molecular imaging probes. Cooperative capture synthesis with architectural control is used to make viable cancer‐specific imaging agents based on molecularly interlocked rotaxanes that feature radiometal ion complexes for positron emission tomography imaging, fluorescent probe...
Published in Angewandte Chemie (International Ed. in English)
A series of rotaxane‐based catalysts in which the mechanical bond between a bipyridine macrocycle and an NDI‐containing axle is intrinsic to their activity is reported. Computational analysis suggests that the high selectivity observed (>60 fold for Michael addition over a competing decarboxylation pathway) is due to π‐stacking of the mechanically ...
Published in Angewandte Chemie (International Ed. in English)
Cobalt carbonyl complexes have been used as temporary masking group, and temporary stoppers, in the synthesis of polyyne [3]rotaxanes with two macrocycles threaded on a C28 thread. Comparison of the thermal stability of two [3]rotaxanes with different threaded macrocycles shows that the 2,6‐pyridyl cycloparaphenylene nanohoop effectively stabilizes...
La nature représente une source d'inspiration inépuisable pour les scientifiques. Depuis de nombreuses années, les chimistes se sont attaqués à la synthèse totale de produits naturels de plus en plus complexes. Ces efforts ont conduit non seulement à la préparation d’analogues artificiels possédant des propriétés inédites, mais également à la décou...
Published in Angewandte Chemie (International ed. in English)
Distant ends in rotaxanes can now talk to each other in a reaction history-dependent manner with the help of a catalytic ring, which shuttles freely between the ends. With this kinetically controlled information transfer mechanism, one end knows whether the other end has reacted, and if yes with what reagent. The end receiving this information then...
Published in Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is expressed highly in various types of tumors. Moreover, the tumor-initiating role of MALAT1 has been probed in the context of breast cancer. This study was set to investigate the regulatory role of MALAT1 on the chemosensitivity of breast c...
Self assembly is the process whereby the interactions between individual molecular components affect association to generate more complex organised structures. Supramolecular chemists have studied such behaviour since the 1960s. Nature has mastered self assembly: living organisms consist of hierarchal structures (organs, cells, organelles) whose fo...
Hierarchical self-assembly of building blocks over multiple length scales is ubiquitous in living organisms. Microtubules are one of the principal cellular components formed by hierarchical self-assembly of nanometer-sized tubulin heterodimers into protofilaments, which then associate to form micron-length-scale, multi-stranded tubes. This peculiar...
Published in Angewandte Chemie (International ed. in English)
The development of sensitive and chemically selective MRI contrast agents is imperative for the early detection and diagnosis of many diseases. Conventional responsive contrast agents used in 1 H MRI are impaired by the high abundance of protons in the body. 129 Xe hyperCEST NMR/MRI comprises a highly sensitive complement to traditional 1 H MRI bec...
