Lama, Rati Wu, Wenjie Mavis, Cory K. Ruiz, Federico M. Querol-García, Javier Martin, Diana Chemler, Sherry R. Chandra, Dhyan Goodrich, David W. Hernandez-Ilizaliturri, Francisco J.
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Published in
Frontiers in Oncology
Rituximab combined with systemic chemotherapy significantly improves the rate of complete response in B-cell lymphomas. However, acquired rituximab resistance develops in most patients leading to relapse. The mechanisms underlying rituximab resistance are not well-understood. MDM2 and MDM4 proteins are major negative regulators of p53, but they als...
Oguni, Kohei Fukushima, Shinnosuke Otsuka, Yuki Soejima, Yoshiaki Kawaguchi, Marina Sazumi, Yosuke Fujimori, Takumi Iio, Koji Umakoshi, Noriyuki Yamada, Kazuki
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Published in
Infection
Ureaplasma urealyticum is a rare pathogen associated with septic arthritis that predominantly affects patients with hypogammaglobulinemia. Bacterial identification of fastidious organisms is challenging because they are undetectable by routine culture testing. To the best of our knowledge, this is the first report of septic arthritis induced by U. ...
Freeman, S A Zéphir, H
Published in
Revue neurologique
Anti-CD20 monoclonal antibodies are highly-effective B-cell-depleting therapies in multiple sclerosis (MS). These treatments have expanded the arsenal of highly effective disease-modifying therapies, and have changed the landscape in understanding the pathophysiology of MS and the natural course of the disease. Nevertheless, these treatments come a...
Smolik, K Camilli, F Panzera, I Fiore, A Franceschini, A Foschi, M Surcinelli, A Pesci, I Ferri, C Bazzurri, V
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Published in
Multiple sclerosis and related disorders
Hypogammaglobulinemia (HG) is a known side effect of treatment with anti-CD20 monoclonal antibodies, and it is associated with the risk of infections. Aim of this retrospective multicentre study was to assess the frequency of HG in Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorder patients treated with Ocrelizumab or Rituximab and ...
Nagle, Sophie Nguyen, Yann Guerry, Mary-Jane Quemeneur, Thomas Titeca-Beauport, Dimitri Crépin, Thomas Mesbah, Rafik Boudhabhay, Idris Pugnet, Grégory Lebas, Céline
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Background The PEXIVAS (Plasma exchange and glucocorticoids in severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis) trial showed that a reduced-dose glucocorticoid regimen (redGC) was non-inferior to a standard-dose regimen (standGC) with respect to death or end-stage kidney disease (ESKD) in patients with ANCA-associated vascul...
Razmjou, Amir Kremer, Joel Pappas, Dimitrios Curtis, Jeffrey Wang, Jennifer Shahbazian, Ani Elashoff, David Guo, Rong Meriwether, David Sulaiman, Dawoud
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OBJECTIVE: Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme, that has been implicated as a biomarker of cardiovascular risk in patients with rheumatoid arthritis (RA). We aimed to investigate how different biologic therapies affect levels of PON1 and oxylipins. METHODS: 1213 adult patients with RA in the Comparative Effect...
vlădulescu-trandafir, andreea-iulia bojincă, violeta-claudia munteanu, constantin anghelescu, aurelian popescu, cristina stoica, simona-isabelle aurelian, sorina bălănescu, andra băetu, cristina ciobanu, vlad
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Rheumatoid arthritis (RA) patients face different health challenges when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than the general population, due to both their immunocompromised state and the immunosuppressive therapies they receive. This systematic literature review, which follows the Preferred Reporting Items fo...
De Meyst, Elias; 158006; Bertrand, Delphine; Joly, Johan; Doumen, Michael; 141143; Marchal, Anja; Thelissen, Marc; Neerinckx, Barbara; 79485; Westhovens, Rene; 8450; Verschueren, Patrick; 4770;
BACKGROUND: The optimal retreatment strategy with rituximab for rheumatoid arthritis (RA) remains a point of discussion. Depending on local guidelines, rituximab can either be administered at fixed intervals or when losing disease control, balancing therapeutic effectiveness with drug overexposure. However, treatment based on loss of disease contro...
Barcellini, Wilma Fattizzo, Bruno
Published in
Transfusion Medicine and Hemotherapy
Background: Autoimmune hemolytic anemia (AIHA) is a rare disease due to increased destruction of erythrocytes by autoantibodies, with or without complement activation. Summary: AIHA is usually classified in warm AIHA (wAIHA) and cold agglutinin disease (CAD), based on isotype and thermal amplitude of the autoantibody. The direct antiglobulin test (...
Yoshii, Ryuichi Kajiwara, Kengo Uemura, Naomichi Matsushita, Koki Nakamura, Tomohumi Tomita, Masao Mukoyama, Masashi
Published in
CEN case reports
While the incidence and prevalence of non-tuberculous mycobacterial-pulmonary disease (NTM-PD) are increasing and microscopic polyangiitis (MPA) is common in East Asian countries, case reports of MPA associated with NTM-PD are limited. A 72-year-old male receiving treatment for NTM-PD with antibiotics was referred to our hospital with fever and art...
