A 30-year-old woman presented to the emergency department 2 days after ingestion of 50 castor beans. Her symptoms on admission were vomiting, diarrhea, abdominal cramps, agitation and anxiety. Initial laboratory tests showed a slightly elevated C-reactive protein (CRP) and mild liver and kidney dysfunction The patient was transferred to the medium ...
The objective was to evaluate the intake, digestibility, nitrogen balance, and metabolic profile of lactating goats fed diets containing detoxified castor cake (DCC) by alkaline solutions during 150 days of lactation. Twenty-four Saanen and Anglo Nubian goats, approximately 17 months old (first lactation) and body weights of 43±2.97 kg, were distri...
Published in African Journal of Emergency Medicine
Introduction >1000 ricin poisoning cases secondary to intentional castor bean consumption have been reported in the literature since the late 1800s. The lethality of ricin poisoning after oral ingestion is determined by a few factors. Case report We present a case that highlights the erratic absorption of ricin after accidental oral ingestion. On a...
Abstract: The effect of substituting soybean meal (SM) with four levels (0, 33, 67 and 100%) of detoxified castor cake (DCC) on intake, nutrient digestibility and nitrogen balance was evaluated in uncastrated, male, crossbred sheep in a randomised complete block design with four treatments and five replications. There was a decreasing linear effect...
ABSTRACT The effect of substituting soybean meal (SM) with four levels (0, 33, 67 and 100%) of detoxified castor cake (DCC) on intake, nutrient digestibility and nitrogen balance was evaluated in uncastrated, male, crossbred sheep in a randomised complete block design with four treatments and five replications. There was a decreasing linear effect ...
Published in Naunyn-Schmiedeberg's Archives of Pharmacology
While probably originating from Africa, the plant Ricinus communis is found nowadays around the world, grown for industrial use as a source of castor oil production, wildly sprouting in many regions, or used as ornamental plant. As regards its pharmacological utility, a variety of medical purposes of selected parts of the plant, e.g., as a laxative...
Published in Metabolomics
IntroductionExposure to ricin can be lethal and treatments that are under development have short windows of opportunity for administration after exposure. It is therefore essential to achieve early detection of ricin exposure to provide the best prognosis for exposed individuals. Ricin toxin can be detected in clinical samples via several antibody-...
Published in Toxicon : official journal of the International Society on Toxinology
The ricin toxin A chain (RTA) is responsible for ricin intoxication due to inhibition of protein synthesis. RTA is also known to cause endothelial toxicity [via a 3 amino acid sequence (x)D(y) motif that acts as a natural disintegrin] resulting in vascular leak syndrome (VLS) in humans. An in vitro endothelial cell toxicity (ECT) assay was develope...
Published in The Journal of International Medical Research
Objective We systematically investigated the cytotoxic effects of ricin in primary pulmonary alveolar macrophages (PAMs). Methods Primary PAMs were isolated from BALB/c mice. The cytotoxic effects of ricin were investigated in vitro by optical and transmission electron microscopy, detection of the inflammatory cytokine response, proteomic analysis,...
Published in Toxicology in vitro : an international journal published in association with BIBRA
Ricin (RT) is a plant toxin belonging to the family of type II ribosome-inactivating protein with high bioterrorism potential. Aerosol RT exposure is the most lethal route, but its mechanism of injury needs further investigation. In the present study, we performed a comprehensive transcriptomics, proteomics and metabolomics analysis on the potentia...
