Mitra, Debanjan Afreen, Shagufta Das Mohapatra, Pradeep K Abdalla, Mohnad
Journal of molecular modeling
The discovery of antiviral approaches to prevent or cure respiratory syncytial virus (RSV) infections is critical, particularly because RSV is one of the most common causes of infant respiratory problems. There is currently no approved vaccination available to treat RSV infections. FDA has approved the drug ribavirin, but it is not sufficient to tr...
Zhang, Wenyan Zhang, Jing Tang, Shan Liu, Yali Du, Xiaofei Qiu, Lixia Liu, Menglu Yu, Haibin Pan, Calvin Q
Journal of clinical and translational hepatology
Decompensated cirrhotic patients with hepatitis C (HCV) are often under-represented in clinical trials. We aimed to evaluate pooled data on the efficacy and safety of sofosbuvir (SOF)-based regimens in these patients. We conducted a systemic review and meta-analysis by searching multiple databases for studies published from October 2010 to October ...
Arora, Rishi Martin, Michelle T Boike, Justin Patel, Sonalie
World journal of hepatology
Glecaprevir/pibrentasvir in combination with sofosbuvir may serve as a safe and effective option for treatment of recurrent hepatitis C virus post-liver transplant in patients who previously failed direct-acting antivirals. ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Baek, Eun Jin Kim, Min Jae Kim, Kwang Il
Fish & shellfish immunology
Viral hemorrhagic septicemia virus (VHSV) causes a severe and often lethal infection in olive flounder (Paralichthys olivaceus) in Korea, resulting in mass mortality and substantial economic loss. As a potential prevention strategy for infectious viral diseases, this study aimed to evaluate the antiviral activity of three compounds (arctigenin [ARG...
Wu, Xiaoping Zhang, Jun Hu, Shengchao Zhang, Gong Lan, Huachun Peng, Jianfeng Liu, Huijuan
The Science of the total environment
The rapid spread of coronavirus disease 2019 has increased the consumption of some antiviral drugs, wherein these are discharged into wastewater, posing risks to the ecosystem and human health. Therefore, efforts are being made for the development of advanced oxidation processes (AOPs) to remediate water containing these pharmaceuticals. Here, the ...
Sun, Qiyuan Yang, Jing Fan, Yongjie Cai, Kaicong Lu, Zhilei He, Zhenle Xu, Zeping Lai, Xingteng Zheng, Yuyi Liu, Changqing
Applied catalysis. B, Environmental
Ribavirin (RBV) is an antiviral drug used for treating COVID-19 infection. Its release into natural waters would threaten the health of aquatic ecosystem. This study reports an effective approach to degrade RBV by the trace N-oxyl compounds (2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) and N-Hydroxyphthalimide (NHPI)) enhanced UV activated free chl...
González-Morcillo, Gonzalo Calderón-Hernanz, Beatriz Serrano-López de Las Hazas, Joaquín de Hita-Santabaya, Ana Isabel Riera-Oliver, Joan
Clinics and research in hepatology and gastroenterology
Chronic Norovirus infection is particularly challenging in patients with common variable immunodeficiency (CVID) because of their inability to achieve viral clearance and the risk of developing enteropathy leading to intestinal villous atrophy and malabsorption. To date, therapeutic options to eliminate the virus are limited and only ribavirin has ...
Yuan, Yang Yang, Xiting Zeng, Qianglin Li, Heyue Fu, Ruyi Du, Lianming Liu, Wei Zhang, Yamei Zhou, Xikun Chu, Yiwen
Frontiers in Microbiology
Pseudomonas aeruginosa relies on its complex cellular regulatory network to produce a series of virulence factors and to cause various acute and chronic infections in a wide range of hosts. Compared with traditional antibiotics which frequently accompany with widespread antibiotic resistance, crippling the virulence system of bacteria is expected t...
Jemth, Ann-Sofie Scaletti, Emma Rose Homan, Evert Stenmark, Pål Helleday, Thomas Michel, Maurice
The Journal of biological chemistry
Remdesivir and molnupiravir have gained considerable interest because of their demonstrated activity against SARS-CoV-2. These antivirals are converted intracellularly to their active triphosphate forms remdesivir-TP and molnupiravir-TP. Cellular hydrolysis of these active metabolites would consequently decrease the efficiency of these drugs; howev...
Burman, Bharat Drutman, Scott B Fury, Matthew G Wong, Richard J Katabi, Nora Ho, Alan L Pfister, David G
Ribavirin inhibits eukaryotic translation initiation factor 4E (eIF4E), thereby decreasing cap-dependent translation. In this two-part study, we assessed the pharmacodynamic effects and therapeutic potential of ribavirin in human papillomavirus (HPV)-related malignancies. In the pharmacodynamic study, ribavirin (400 mg BID for 14 days) was evaluate...