Zheng, Adi Dubuis, Gilles Georgieva, Maria Mendes Ferreira, Carla Susana Serulla, Marc del Carmen Conde Rubio, Maria Trofimenko, Evgeniya Mercier, Thomas Decosterd, Laurent Widmann, Christian
...
Published in
Journal of Cell Science
Summary: HDLs, akin to their capacity for extracting cholesterol, can remove lipophilic compounds from cells, thus protecting the cells when these compounds are toxic.
Esteras, Noemí Adjobo-Hermans, Merel J.W. Abramov, Andrey Y. Koopman, Werner J.H.
Assessment of the mitochondrial membrane potential (Δψ) in living cells, although not trivial, can be used to estimate mitochondrial bioenergetic state. For this purpose, fluorescent lipophilic cations are broadly applied. These cations enter cells and accumulate primarily in the mitochondrial matrix in a Δψ-dependent manner. Here, we describe the ...
Levy, Elizabeth S Samy, Karen E Lamson, Nicholas G Whitehead, Kathryn A Kroetz, Deanna L Desai, Tejal A
Oral drug delivery is a preferred administration route due to its low cost, high patient compliance and fewer adverse events compared to intravenous administration. However, many pharmaceuticals suffer from poor solubility and low oral bioavailability. One major factor that contributes to low bioavailability are efflux transporters which prevent dr...
Cleach, Jérôme
La fraîcheur est un paramètre clé de la qualité du poisson. Les méthodes actuelles appliquées enroutine pour déterminer la fraîcheur du poisson ne sont pas applicables à toutes les espèces et reflètentdavantage un début d’altération du produit. Ainsi, la recherche d’indicateurs précoces de fraîcheur dupoisson représente encore un défi majeur et d’a...
Cléach, Jérôme
La fraîcheur est un paramètre clé de la qualité du poisson. Les méthodes actuelles appliquées en routine pour déterminer la fraîcheur du poisson ne sont pas applicables à toutes les espèces et reflètent davantage un début d'altération du produit. Ainsi, la recherche d'indicateurs précoces de fraîcheur du poisson représente encore un défi majeur et ...
Baranyaiová, Tímea Bujdák, Juraj
Published in
Clays and Clay Minerals
The molecular aggregation of organic dyes onto clay mineral particles is a very complex phenomenon including dye adsorption, the migration of dye molecules, rearrangement of initially formed aggregates, etc. Some details of this complex process are not yet fully understood. The objective of the present study was to understand the influence of dye s...
Gerber, Werner Hamman, Josias H Steyn, Johan D
Published in
Journal of food and drug analysis
Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions may be caused by modulation of efflux transporter proteins, intercellular tight junctions and/or metabolic enzyme amongst oth...
Ozgür, Burak Saaby, Lasse Langthaler, Kristine Brodin, Birger
Published in
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Recently, we transfected the porcine intestinal cell line IPEC-J2, with human P-glycoprotein (P-gp, ABCB1). The resulting cell line, iP-gp, has a high expression of functional human P-gp in the apical membrane, and a low expression of nonhuman ATP-binding cassette (ABC) transporters. The aim of the present work was to investigate the usability of i...
h.-y., tan trier, s. u.l., rahbek dufva, m. j.p., kutter t.l., andresen
10.1371/journal.pone.0197101 / PLoS ONE / 13 / 5 / e0197101
Shojaee Sadi, Behrooz Bayat, Mansour Tajik, Parviz Hashemi, Seyed Jamal
Published in
Saudi journal of biological sciences
The specific immune-reaction between the anti-citrinin antibody immobilized on the surface of magnetic/silica core-shell (MSCS) and the citrinin-Rho123-BSA conjugate brings the Rho123 fluorophore as an acceptor and the QDs as a donor in close spatial proximity and causes FRET for occurring upon photo-excitation of the QDs. The novelties of this stu...
