Leroi, Hermine Badot, Valérie De Keyser, Filip Devinck, Mieke Geusens, Piet Kleimberg, Sandra Swinnen, Carine Roggeman, Chantal
Published in
Rheumatology and therapy
The main objective of this study was to assess the level of nursing support received by biologic-naïve rheumatological patients treated with golimumab during their first cycle. Adult patients (N = 119; aged 46.9 ± 13.4 years (mean ± standard deviation); 49.6% males), with rheumatoid arthritis (N = 40), ankylosing spondylitis (N = 58) or psoriatic a...
Li, Yanpeng Tong, Dongmei Liang, Peibin Lönnblom, Erik Viljanen, Johan Xu, Bingze Nandakumar, Kutty Selva Holmdahl, Rikard
Published in
Arthritis Research & Therapy
BackgroundAntibodies binding to cartilage proteins are present in the blood and synovial fluid of early rheumatoid arthritis patients. In order to develop animal models mimicking the human disease, we have characterized the arthritogenic capacity of monoclonal antibodies directed towards different joint proteins in the cartilage.MethodsPurified ant...
Qu, Zihao Huang, Jiawei Yang, Fangkun Hong, Jianqiao Wang, Wei Yan, Shigui
Published in
Arthritis Research & Therapy
BackgroundSex hormone-binding globulin (SHBG) has been reported to be a risk factor associated with the development of arthritis by previous observational studies more so of three common forms of arthritis: osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). This study aimed to determine whether the concentrations of ci...
Andersson, Sofia E. M. Lange, Elvira Kucharski, Daniel Svedlund, Sara Önnheim, Karin Bergquist, Maria Josefsson, Elisabet Lord, Janet M. Mårtensson, Inga-Lill Mannerkorpi, Kaisa
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Published in
Immunity & Ageing
ObjectiveExercise can improve immune health and is beneficial for physical function in patients with rheumatoid arthritis (RA), but the immunological mechanisms are largely unknown. We evaluated the effect of moderate- to high intensity exercise with person-centred guidance on cells of the immune system, with focus on regulatory cell populations, i...
Lee, Ha-Reum Yoo, Su-Jin Kim, Jinhyun Yoo, In Seol Park, Chan Keol Kang, Seong Wook
Published in
Arthritis Research & Therapy
BackgroundReactive oxygen species (ROS) regulate the migration and invasion of fibroblast-like synoviocytes (FLS), which are key effector cells in rheumatoid arthritis (RA) pathogenesis. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) induces ROS generation and, consequently, enhances cell migration. Despite the important interrelation...
Emery, Paul Tanaka, Yoshiya Cardillo, Tracy Schlichting, Douglas Rooney, Terence Beattie, Scott Helt, Cameron Smolen, Josef S.
Published in
Arthritis Research & Therapy
BackgroundIn clinical practice, temporary interruption of rheumatoid arthritis (RA) therapy is common for various reasons including side effects, non-compliance, or necessity for surgery. To characterize temporary interruptions of baricitinib and placebo-matched tablets in phase 3 studies of patients with moderate-to-severe rheumatoid arthritis (RA...
Peng, Hsin-Yi Chen, Shih-Yao Siao, Shih-Hong Chang, Jinghua Tsai Xue, Ting-Yin Lee, Yi-Hsuan Jan, Ming-Shiou Tsay, Gregory J. Zouali, Moncef
Published in
Arthritis Research & Therapy
BackgroundSeveral lines of evidence suggest that the pathobiont Porphyromonas gingivalis is involved in the development and/or progression of auto-inflammatory diseases. This bacterium produces cysteine proteases, such as gingipain RgpA, endowed with the potential to induce significant bone loss in model systems and in patients.ObjectiveWe sought t...
Drosos, Alexandros A. Pelechas, Eleftherios Voulgari, Paraskevi V.
Published in
Current Rheumatology Reports
Purpose of ReviewRheumatoid arthritis (RA) is a chronic inflammatory disease affecting mainly the peripheral skeleton in a symmetrical manner rather than the axial skeleton, but when it occurs it can affect the cervical spine (CS). Although CS involvement is a frequent radiographic finding in RA, the clinical features are scarce, but potentially li...
Gao, Jinfang Zhang, Gailian Xu, Ke Ma, Dan Ren, Limin Fan, Jingjing Hou, Jianwen Han, Jian Zhang, Liyun
Published in
Stem Cell Research & Therapy
BackgroundRheumatoid arthritis (RA) is characterized by joint inflammation and damage to the cartilage and bone in collagen-induced arthritis (CIA). Mesenchymal stem cells (MSCs) can improve articular symptoms and reduce bone erosion in CIA rats; however, the underlying mechanism remains unknown. This study aimed to investigate the mechanism underl...
Song, Yun-Jeong Choi, In Ah. Meylan, Françoise Demoruelle, M. Kristen Farley, Taylor Richard, Arianne C. Hawley, Eric Botson, John Hong, Yoo Jin Lee, Eun Young
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Published in
Arthritis Research & Therapy
BackgroundThe tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis (RA). However, the relationship of TL1A to disease duration, activity, and response to anti-TNF and other therapies in RA is not cl...
