Solomon, Daniel H. Xu, Chang Collins, Jamie Kim, Seoyoung C. Losina, Elena Yau, Vincent Johansson, Fredrik D.
Published in
Arthritis Research & Therapy
BackgroundThere are numerous non-biologic and biologic disease-modifying anti-rheumatic drugs (bDMARDs) for rheumatoid arthritis (RA). Typical sequences of bDMARDs are not clear. Future treatment policies and trials should be informed by quantitative estimates of current treatment practice.MethodsWe used data from Corrona, a large real-world RA reg...
Rydell, Emil Forslind, Kristina Nilsson, Jan-Åke Karlsson, Magnus Åkesson, Kristina E. Jacobsson, Lennart T. H. Turesson, Carl
Published in
Arthritis Research & Therapy
BackgroundRadiographic damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Different mechanisms may underlie their development. The objective of this study was to evaluate predictors of these entities separately.MethodsConsecutive early RA patients (symptom duration ≤12 months) from a defined area (Malmö, Sweden) ...
Murray, Kieran Turk, Matthew Alammari, Yousef Young, Francis Gallagher, Phil Saber, Tajvur Fearon, Ursula Veale, Douglas J.
Published in
Arthritis Research & Therapy
BackgroundBiologic therapies have greatly improved outcomes in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Yet, our ability to predict long-term remission and persistence or continuation of therapy remains limited. This study explores predictors of remission and persistence of the initial biologic therapy in patients after 12 years. Fu...
Dupuis, Maria Luisa Pagano, Maria Teresa Pierdominici, Marina Ortona, Elena
Published in
Biology of Sex Differences
Over the last decades, a central role for vitamin D in immune modulation has been well established. The active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, through the interaction with vitamin D receptor, exerts different activities on the innate and adaptive immune system, among which suppression of inflammation and promotion of tolerogenic r...
Canavan, Mary Floudas, Achilleas Veale, Douglas J. Fearon, Ursula
Published in
BMC Rheumatology
The activation of antigen specific T cells during an immune response is a tightly regulated process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory receptor or checkpoint inhibitor which has received much attention in the field of oncology is the programmed cell death protein 1 (PD-1). Blockade of PD-1 or its li...
Simon, Teresa A. Dong, Lixian Winthrop, Kevin L.
Published in
Arthritis Research & Therapy
BackgroundTo evaluate incidence of opportunistic infections (OIs) in patients with rheumatoid arthritis (RA) treated with abatacept in clinical trials.MethodsThis pooled analysis of 16 randomized, double-blind/open-label trials, with ≥ 1 abatacept (intravenous or subcutaneous) arm, and with/without placebo control covered cumulative (controlled sho...
Liu, Jianyong Chen, Ningjie
Published in
Journal of Orthopaedic Surgery and Research
BackgroundRheumatoid arthritis (RA) is an autoimmune rheumatic disease that carries a substantial burden for both patients and society. Early diagnosis of RA is essential to prevent disease progression and select an optimal therapeutic strategy. However, RA diagnosis is challenging, partly due to a lack of reliable biomarkers. Here, we aimed to exp...
Hammond, Alison Prior, Yeliz Cotterill, Sarah Sutton, Chris Camacho, Elizabeth Heal, Calvin Adams, Jo Hough, Yvonne O’Neill, Terence W. Firth, Jill
...
Published in
BMC Musculoskeletal Disorders
BackgroundArthritis (or compression) gloves are widely prescribed to people with rheumatoid arthritis and other forms of hand arthritis. They are prescribed for daytime wear to reduce hand pain and improve hand function, and/or night-time wear to reduce pain, improve sleep and reduce morning stiffness. However, evidence for their effectiveness is l...
Tański, Wojciech Gać, Paweł Chachaj, Angelika Mazur, Grzegorz Poręba, Rafał Szuba, Andrzej
Published in
Insights into Imaging
PurposeThe aim of the study was to assess a relationship between the occurrence of rheumatoid arthritis (RA) and its selected clinical parameters, and left ventricular myocardial strain.Material and methodsFifty-six subjects were qualified for the study: 30 RA patients and 26 subjects without rheumatoid diseases. The study design included taking me...
Davignon, Jean-Luc Combe, Bernard Cantagrel, Alain
Published in
Arthritis Research & Therapy
Human cytomegalovirus (HCMV) is a β-herpesvirus that causes inflammation and remains for life in a latent state in their host. HCMV has been at the center of many hypotheses regarding RA. We have recently shown that HCMV infection impairs bone erosion through the induction of the mRNA-binding protein QKI5. Latently infected RA patients display a sl...
