Correspondence regarding recently published editorial: ‘Will children reveal their secret? The coronavirus dilemma’
Reply to: one step at a time: a phased approach to behavioral treatment development in pulmonary rehabilitation.
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Contemporary Concise Review 2019: Sleep and ventilation.
Airway Occlusion Pressure Revisited.
Heme metabolism genes Downregulated in COPD Cachexia.
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INTRODUCTION:Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify differential gene expression signatures associated with COPD cachexia in current and former smokers. METHODS:We analyzed whole-bl...
CYP2A13 Acts as the Main Metabolic CYP450s Enzyme for Activating Leonurine in Human Bronchial Epithelial Cells
Published in Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Leonurine is an active component of the traditional Chinese medicine Leonurus japonicus . This study aimed to investigate the effects of overexpressed CYP450s on the metabolic activity of leonurine. Material/Methods BEAS-2B cells stably expressing CYP1A1, 1A2, 2A13, 2B6, and 3A4 were constructed. CYP450s expression was identified using r...
Recommended reading from the genomic and environmental medicine section.
Quality of life, tuberculosis and treatment outcome; a case-control and nested cohort study
BACKGROUND: Global tuberculosis policy increasingly emphasises broad tuberculosis impacts and highlights the lack of evidence concerning tuberculosis-related quality of life (QOL). METHODS: Participants were recruited in 32 Peruvian communities 13/7/2016-24/2/2018 and followed-up until 8/11/2019. Inclusion criteria were: age ≥15 years for "patients...
Temporal trends in the incidence of heart failure among patients with COPD and its association with mortality
Rationale: Heart failure (HF) is a common comorbidity in the chronic obstructive pulmonary disease (COPD) population, but previous research has shown under recognition. Objectives: To determine the incidence of HF in a prevalent COPD cohort. To determine the association of incident HF with short- and long-term mortality of patients with COPD. Metho...
The randomized embedded multifactorial adaptive platform for community-acquired pneumonia (REMAP-CAP) study: rationale a...
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There is broad interest in improved methods to generate robust evidence regarding best practice, especially in settings where patient conditions are heterogenous and require multiple concomitant therapies. Here, we present the rationale and design of a large, international trial that combines features of adaptive platform trials with pragmatic poin...
